Method and composition for making an oral soluble film, containing at least one active agent

    公开(公告)号:US11090262B2

    公开(公告)日:2021-08-17

    申请号:US16245274

    申请日:2019-01-11

    IPC分类号: A61K9/00 A61K9/70

    摘要: A method of making an oral soluble film, containing at least one active agent, includes providing a well of a predetermined size; depositing a film forming composition in the well; depositing an active agent composition in the well, the active agent composition being different than the film forming composition, the film forming composition and the active agent composition forming an admixture in the well; and drying the admixture in the well. Alternatively, the method includes providing a well of a predetermined size; depositing a film forming composition including at least one active agent in the well, the film forming composition having a viscosity below 2000 centipoise; and drying the film forming composition in the well.

    Method and system to amplify and measure breath analytes

    公开(公告)号:US11064907B2

    公开(公告)日:2021-07-20

    申请号:US15709494

    申请日:2017-09-20

    IPC分类号: A61B5/097 A61B5/08 G01N33/497

    摘要: A method of avoiding a contaminant which would skew an analyte result in a breath analysis method and of calibrating subject of the breath analysis includes, immediately before the breath analysis method or the collection of breath for the breath analysis method, administering to the subject a predetermined gas composition. A system for analyzing an analyte in breath of a subject while avoiding a local contaminant which would skew an analyte result and calibrating the subject of so that the result of the analyte analysis will be the same regardless of where the test is performed geographically, includes a source of a predetermined gas composition immediately before the breath analysis method or the collection of gas for the breath analysis method, administering to the subject a predetermined gas mixture.

    Method and apparatus for permitting stage-door access to on-line vendor information
    65.
    发明授权
    Method and apparatus for permitting stage-door access to on-line vendor information 有权
    允许阶段门访问在线供应商信息的方法和装置

    公开(公告)号:US08620756B2

    公开(公告)日:2013-12-31

    申请号:US13594371

    申请日:2012-08-24

    IPC分类号: G06Q40/00

    摘要: The present invention provides Internet users with access to an on-line vendor that has detailed product information some or all of which is supplied by at least one product supplier. Through selected storage and sharing of data, an on-line store is married to a supplier's product database. The on-line vendor is able to provide greater product information at a vastly reduced cost. The product supplier is provided with a unique company forum in which company activities such as sales training can be consolidated with advertising activities and product information to provide the most economical and up-to-date training information for the company.

    摘要翻译: 本发明为互联网用户提供对具有详细产品信息的在线供应商的访问,其中一些或全部由至少一个产品供应商提供。 通过选定的数据存储和共享,在线商店与供应商的产品数据库结婚。 在线供应商能够以大大降低成本提供更大的产品信息。 产品供应商提供了一个独特的公司论坛,其中可以通过广告活动和产品信息整合销售培训等公司活动,为公司提供最经济,最新的培训信息。

    Extrudable and extruded compositions for delivery of bioactive agents, method of making same and method of using same
    66.
    发明授权
    Extrudable and extruded compositions for delivery of bioactive agents, method of making same and method of using same 有权
    用于递送生物活性剂的可挤出和挤出组合物,其制备方法及其使用方法

    公开(公告)号:US08613285B2

    公开(公告)日:2013-12-24

    申请号:US12757936

    申请日:2010-04-09

    申请人: Richard C. Fuisz

    发明人: Richard C. Fuisz

    IPC分类号: A24B15/00

    摘要: A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. An extruded bioactive product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and a bioactive agent, the sheet being soluble in a user's mouth and resulting in sustained release of bioactive to the user. The sheet can be in a form that may be placed in contact with the mucosa of the user, and have an average dissolution time of 5 to 50 minutes for delivering the bioactive to the user.

    摘要翻译: 非水可挤出组合物包含至少一种热塑性聚合物,其量超过整个组合物的20重量%和烟草。 片状形式的挤出的生物活性产品可以通过挤出或热熔成型包含至少一种热塑性聚合物和生物活性剂的非水性组合物来制备,该片材可溶于使用者的口中并导致生物活性物质持续释放至 用户。 片材可以是可以与使用者的粘膜接触的形式,并且具有5至50分钟的平均溶解时间以将生物活性递送给使用者。

    Solid dosage form that promotes reliable oral, esophageal and GI transit

    公开(公告)号:US08383135B2

    公开(公告)日:2013-02-26

    申请号:US13079285

    申请日:2011-04-04

    IPC分类号: A61K9/00

    摘要: A solid dosage form designed to facilitate rapid and reliable oral, esophageal and GI transit has a surface area of the contact patch, i.e., the area of contact between the dosage form and the bodily surface reduced. The dosage form can be an asymmetric oral dosage unit containing a bioactive, the dosage unit being asymmetric with respect to a rotational axis perpendicular to a longitudinal axis of the dosage form, the rotational axis being located substantially at a mid point along the longitudinal axis. The dosage unit may have an outer surface ridged or dimpled or have at least one annular ring so as to reduce the contact patch of the dosage unit with a flat surface compared to non-ridged dosage unit of the same size and shape. The oral dosage unit can also have a spherical shape with or without ridges and/or dimples. Dies for forming these oral dosage units have, in a closed state, a cavity having a shape corresponding to the oral dosage unit.

    Methods for determining customer motivations in purchasing decisions
    68.
    发明授权
    Methods for determining customer motivations in purchasing decisions 有权
    在采购决策中确定客户动机的方法

    公开(公告)号:US08335725B2

    公开(公告)日:2012-12-18

    申请号:US13112492

    申请日:2011-05-20

    IPC分类号: G06Q30/00

    摘要: Systems, methods, and apparatus for determining motivator counts associated with purchase selections are presented herein. A data store can be configured to store purchase selections of respective products. A server can be configured to determine an incremental purchase time between a first purchase selection of the purchase selections and a second purchase selection of the purchase selections. Further, the server can be configured to determine a standard deviation of incremental purchase times between respective purchase selections of the purchase selections. Furthermore, the server can be configured to increment a prime motivator count associated with the second purchase selection based on the incremental purchase time and the standard deviation.

    摘要翻译: 本文给出了用于确定与购买选择相关联的激励因子计数的系统,方法和装置。 数据存储可以被配置为存储各个产品的购买选择。 可以将服务器配置为确定购买选择的第一次购买选择和购买选择的第二购买选择之间的增量购买时间。 此外,服务器可以被配置为确定购买选择的相应购买选择之间的增量购买时间的标准偏差。 此外,服务器可以被配置为基于增量购买时间和标准偏差来增加与第二购买选择相关联的主要激励因子计数。

    Cipher watch
    69.
    发明授权
    Cipher watch 失效
    密码表

    公开(公告)号:US08264910B2

    公开(公告)日:2012-09-11

    申请号:US12966079

    申请日:2010-12-13

    CPC分类号: G04B47/003

    摘要: A watch able to be used as a cryptographic system to encrypt plaintext to ciphertext or decrypt ciphertext to plaintext includes a watch face and a plurality of concentric rings. Each of the plurality of concentric rings is rotatable with respect to the watch face and includes a number of symbols, the number of symbols corresponding to the number of hours represented on the watch face, at least some of the symbols corresponding to letters of an alphabet, characters in a writing system and/or numbers. At least one of the plurality of concentric rings is rotatable in a direction opposite to a direction of at least one other of the plurality of concentric rings.

    摘要翻译: 可以将密码系统用于将明文加密为密文或将密文解密为明文的手表包括表面和多个同心圆。 多个同心环中的每一个可相对于表面旋转,并且包括多个符号,对应于在表面上表示的小时数的符号的数量,对应于字母表的字母的至少一些符号 ,写作系统中的字符和/或数字。 多个同心环中的至少一个可以在与多个同心环中的至少另一个的方向相反的方向上旋转。

    SMOKELESS TOBACCO PRODUCT
    70.
    发明申请
    SMOKELESS TOBACCO PRODUCT 审中-公开
    无烟烟草制品

    公开(公告)号:US20100242978A1

    公开(公告)日:2010-09-30

    申请号:US12757960

    申请日:2010-04-09

    申请人: Richard C. Fuisz

    发明人: Richard C. Fuisz

    IPC分类号: A24B15/00

    摘要: A nonaqueous, extrudable composition includes at least one thermoplastic polymer in an amount of more than 20 wt % of the whole composition and tobacco. A smokeless tobacco product in the form of a sheet can be made by extruding or hot melt shaping a nonaqueous composition comprising at least one thermoplastic polymer and tobacco, the sheet being soluble in a user's mouth and resulting in sustained release of nicotine to the user. The sheet can be in a form that may be placed in the buccal cavity of, on the palate of or sublingually in the user, and have an average dissolution time of 5 to 50 minutes for delivering super bioavailable nicotine to the user.

    摘要翻译: 非水可挤出组合物包含至少一种热塑性聚合物,其量超过整个组合物的20重量%和烟草。 片状形式的无烟烟草制品可以通过将包含至少一种热塑性聚合物和烟草的非水性组合物挤出或热熔成型制成,该片材可溶于使用者的口中并导致尼古丁向使用者持续释放。 该片材可以是可以放置在使用者口中或舌下的口腔中,并且具有5至50分钟的平均溶解时间以向使用者输送超级生物可利用尼古丁。