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公开(公告)号：US09460906B2
公开(公告)日：2016-10-04
申请号：US11813221
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap by the application of an AC or RF voltage to the electrodes. A static potential well is maintained along at least a portion of the axial length of the ion guide or ion trap. A time varying homogeneous electric field is applied along at least a portion of the axial length of the ion guide or ion trap. The combination of the static axial potential well and the time varying axial homogeneous electric field causes ions to be ejected from the ion guide or ion trap in a substantially non-resonant manner.
摘要翻译： 公开了一种离子导向器或离子阱，其包括分段线性离子导向器或离子阱。 通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱内径向。 沿着离子导向器或离子阱的轴向长度的至少一部分保持静电势阱。 沿着离子导向器或离子阱的轴向长度的至少一部分施加时变均匀电场。 静态轴向势阱和随时间变化的轴向均匀电场的组合导致离子以基本上非共振的方式从离子导向器或离子阱排出。
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公开(公告)号：US08106350B2
公开(公告)日：2012-01-31
申请号：US11816643
申请日：2006-02-22
IPC分类号： H01J49/26
CPC分类号： H01J49/025 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.
摘要翻译： 公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数 记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。
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公开(公告)号：US20100327157A1
公开(公告)日：2010-12-30
申请号：US12518173
申请日：2007-12-10
申请人： Martin Green , Jason Lee Wildgoose
发明人： Martin Green , Jason Lee Wildgoose
IPC分类号： H01J49/40
CPC分类号： H01J49/403 , H01J49/065 , H01J49/40 , H01J49/4225 , H01J49/426
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyser (7). The time of flight mass analyser (7) comprises an ion guide comprising a plurality of electrodes (1) which are interconnected by a series of resistors (2) forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes (1). A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.
摘要翻译： 公开了一种包括飞行时间质量分析器（7）的质谱仪。 飞行时间质量分析器（7）包括离子导向器，其包括由形成分压器的一系列电阻器（2）互连的多个电极（1）。 通过向电极（1）施加两相RF电压，离子在径向上被限制在离子导向器内。 在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。
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公开(公告)号：US08847153B2
公开(公告)日：2014-09-30
申请号：US11722970
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap 1 is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap 1 by the application of an AC or RF voltage to the electrodes. Ions are trapped within an axial quadratic potential well which is oscillated or modulated axially so as to cause ions to be ejected from the ion guide or ion trap 1 in a substantially non-resonant manner.
摘要翻译： 公开了一种离子导向器或离子阱1，其包括分段线性离子导向器或离子阱。 通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱1的径向内。 离子被捕获在轴向二次势阱内，其轴向振荡或调制，从而使离子以基本上非共振的方式从离子导向器或离子阱1喷出。
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公开(公告)号：US08779354B2
公开(公告)日：2014-07-15
申请号：US13453657
申请日：2012-04-23
CPC分类号： H01J49/0481 , H01J49/0072 , H01J49/065 , H01J49/40 , Y10T436/24
摘要： A mass spectrometer is disclosed comprising an Electron Transfer Dissociation cell. Positive analyte ions are fragmented into fragment ions upon colliding with singly charged negative reagent ions with the cell. The cell comprises a plurality of ring electrodes which form a spherical trapping volume. Ions experience negligible RF heating over the majority of the trapping volume which enables the kinetic energy of the analyte and reagent ions to be reduced to just above thermal temperatures. An Electron Transfer Dissociation cell having an enhanced sensitivity is thereby provided. Fragment ions created within the cell may be cooled and may be transmitted onwardly to an orthogonal acceleration Time of Flight mass analyser enabling a significant improvement in the resolution of the mass analyser to be obtained.
摘要翻译： 公开了一种质谱仪，其包括电子转移解离单元。 当与单体电荷的负试剂离子碰撞时，阳性分析物离子被碎裂成碎片离子。 电池包括形成球形捕获体积的多个环形电极。 在大多数捕集体积下，离子经历可忽略的RF加热，使得分析物和试剂离子的动能能够降低到高于热温度。 从而提供具有增强的灵敏度的电子转移解离电池。 在细胞内产生的片段离子可以被冷却并且可以向内传播到正交加速时间飞行质量分析仪，使得可以获得质量分析仪的分辨率的显着提高。
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公开(公告)号：US08598518B2
公开(公告)日：2013-12-03
申请号：US12518173
申请日：2007-12-10
申请人： Martin Green , Jason Lee Wildgoose
发明人： Martin Green , Jason Lee Wildgoose
CPC分类号： H01J49/403 , H01J49/065 , H01J49/40 , H01J49/4225 , H01J49/426
摘要： A mass spectrometer is disclosed comprising a time of flight mass analyzer. The time of flight mass analyszr comprises an ion guide comprising a plurality of electrodes which are interconnected by a series of resistors forming a potential divider. Ions are confined radially within the ion guide by the application of a two-phase RF voltage to the electrodes. A single phase additional RF voltage is applied across the potential divider so that an inhomogeneous pseudo-potential force is maintained along the length of the ion guide.
摘要翻译： 公开了一种质谱仪，其包括飞行时间质量分析器。 飞行时间质量分析器包括离子导向器，其包括通过一系列形成分压器的电阻器互连的多个电极。 离子通过向电极施加两相RF电压而在离子导向器内径向限制。 在分压器上施加单相附加RF电压，使得沿着离子导向器的长度保持不均匀的伪势力。
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公开(公告)号：US20090014637A1
公开(公告)日：2009-01-15
申请号：US11722970
申请日：2006-01-17
申请人： Kevin Giles , Martin Green , Jason Lee Wildgoose
发明人： Kevin Giles , Martin Green , Jason Lee Wildgoose
IPC分类号： B01D59/44
CPC分类号： H01J49/4235 , H01J49/4275
摘要： An ion guide or ion trap 1 is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap 1 by the application of an AC or RF voltage to the electrodes. Ions are trapped within an axial quadratic potential well which is oscillated or modulated axially so as to cause ions to be ejected from the ion guide or ion trap 1 in a substantially non-resonant manner.
摘要翻译： 公开了一种离子导向器或离子阱1，其包括分段线性离子导向器或离子阱。 通过向电极施加AC或RF电压，离子限制在离子导向器或离子阱1的径向内。 离子被捕获在轴向二次势阱内，其轴向振荡或调制，从而使离子以基本上非共振的方式从离子导向器或离子阱1喷出。
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68.发明授权Mass spectrometer device and method using scanned phase applied potentials in ion guidance 有权离子引导中使用扫描相应用电位的质谱仪装置和方法公开(公告)号：US08455819B2
公开(公告)日：2013-06-04
申请号：US13078198
申请日：2011-04-01
CPC分类号： H01J49/065 , H01J49/0031 , H01J49/022 , H01J49/062 , H01J49/36 , H01J49/4235 , Y10T436/24
摘要： An ion guide or mass analyser is disclosed comprising a plurality of electrodes having apertures through which ions are transmitted in use. A pseudo-potential barrier is created at the exit of the ion guide or mass analyser. The amplitude or depth of the pseudo-potential barrier is inversely proportional to the mass to charge ratio of an ion. One or more transient DC voltages are applied to the electrodes of the ion guide or mass analyser in order to urge ions along the length of the ion guides or mass analyser. The amplitude of the transient DC voltage applied to the electrode may be increased with time so that ions are caused to be emitted from the ion guide or mass analyser in reverse order of their mass to charge ratio.
摘要翻译： 公开了一种离子导向器或质量分析器，其包括具有孔的多个电极，在使用中离子传播通过该孔。 在离子导向器或质量分析器的出口处产生伪势垒。 伪势垒的幅度或深度与离子的质荷比成反比。 一个或多个瞬态直流电压被施加到离子导向器或质量分析器的电极，以沿着离子导向器或质量分析器的长度推动离子。 施加到电极的瞬态直流电压的幅度可以随时间增加，使得离子从离子导向器或质量分析器以其质荷比的相反顺序被发射。
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公开(公告)号：US08183524B2
公开(公告)日：2012-05-22
申请号：US12516610
申请日：2007-12-14
IPC分类号： H01J49/00
CPC分类号： H01J49/401
摘要： A mass spectrometer is disclosed comprising an orthogonal acceleration Time of Flight mass analyser. A pulse or packet of ions is released either from an ion trap or alternatively from a travelling wave ion guide arranged upstream of an orthogonal acceleration electrode which forms part of the Time of Flight mass analyser. Ions in the pulse or packet or ions which is released become temporally dispersed and the orthogonal acceleration electrode is energized multiple times prior the release of a subsequent pulse or packet of ions.
摘要翻译： 公开了一种质谱仪，其包括正交加速时间飞行质量分析器。 离子的脉冲或分组从离子阱或者替代地布置在构成飞行时间质量分析器的一部分的正交加速电极的上游的行波离子导向器释放。 释放的脉冲或包或离子中的离子变得暂时分散，并且在随后的脉冲或包离子的释放之前，正交加速电极被多次通电。
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公开(公告)号：US20090057547A1
公开(公告)日：2009-03-05
申请号：US11816643
申请日：2006-02-22
CPC分类号： H01J49/025 , H01J49/0036 , H01J49/40
摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.
摘要翻译： 公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数 记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。
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