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公开(公告)号:US08383356B2
公开(公告)日:2013-02-26
申请号:US13366068
申请日:2012-02-03
CPC分类号: G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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公开(公告)号:US08337813B2
公开(公告)日:2012-12-25
申请号:US12210829
申请日:2008-09-15
申请人: Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人: Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
IPC分类号: A61B5/055
CPC分类号: A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要: The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译: 本发明一般涉及多模式磁共振成像(MRI)造影剂。 特别地,本发明提供了构造成操纵周围水质子旋转的纵向(T1)和横向(T2)弛豫时间的MRI造影剂。
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公开(公告)号:US20120156709A1
公开(公告)日:2012-06-21
申请号:US13353001
申请日:2012-01-18
申请人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号: G01N27/00
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移过程的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号:US08114661B2
公开(公告)日:2012-02-14
申请号:US12773382
申请日:2010-05-04
CPC分类号: G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译: 本发明涉及使用电子技术,特别是AC技术检测目标分析物。
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公开(公告)号:US20110177008A1
公开(公告)日:2011-07-21
申请号:US13008576
申请日:2011-01-18
申请人: Lisa M. Manus , Daniel J. Mastarone , Dean Ho , Thomas J. Meade
发明人: Lisa M. Manus , Daniel J. Mastarone , Dean Ho , Thomas J. Meade
CPC分类号: A61K49/1881
摘要: The present invention provides compositions and methods for the synthesis of conjugates of paramagnetic metal ions and nanodiamonds, and uses thereof. In particular, the present invention provides synthesis of paramagnetic metal-nanodiamond conjugates and methods using such compositions as molecular imaging probes.
摘要翻译: 本发明提供了用于合成顺磁性金属离子和纳米金刚石的共轭物的组合物和方法及其用途。 特别地,本发明提供顺磁金属 - 纳米金刚石缀合物的合成和使用这种组合物作为分子成像探针的方法。
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公开(公告)号:US07713711B2
公开(公告)日:2010-05-11
申请号:US11981735
申请日:2007-10-30
CPC分类号: G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译: 本发明涉及使用电子技术,特别是AC技术检测目标分析物。
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公开(公告)号:US20100029909A1
公开(公告)日:2010-02-04
申请号:US12471731
申请日:2009-05-26
IPC分类号: C07K14/575 , C07K14/435 , G01R33/48
CPC分类号: A61K49/10 , A61K49/085
摘要: The present invention relates to compositions and methods for imaging with magnetic resonance contrast agents. In particular, the present invention provides targeted contrast agents for selective imaging.
摘要翻译: 本发明涉及用磁共振造影剂成像的组合物和方法。 特别地,本发明提供了用于选择性成像的靶向造影剂。
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公开(公告)号:US20100003710A1
公开(公告)日:2010-01-07
申请号:US12253828
申请日:2008-10-17
申请人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人: Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
CPC分类号: G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译: 本发明涉及使用电子转移方法的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号:US20090196829A1
公开(公告)日:2009-08-06
申请号:US12359914
申请日:2009-01-26
申请人: Ying Song , Thomas J. Meade , Ellen Kohlmeir
发明人: Ying Song , Thomas J. Meade , Ellen Kohlmeir
IPC分类号: A61K49/08
CPC分类号: A61K49/124
摘要: The present invention relates to contrast agents for MRI and related methods of use.
摘要翻译: 本发明涉及用于MRI的造影剂和相关使用方法。
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公开(公告)号:US20090173640A1
公开(公告)日:2009-07-09
申请号:US11981645
申请日:2007-10-30
CPC分类号: G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要: The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
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