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公开(公告)号：US20090269284A1
公开(公告)日：2009-10-29
申请号：US12210829
申请日：2008-09-15
申请人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译： 本发明一般涉及多模式磁共振成像（MRI）造影剂。 特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。
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公开(公告)号：US08337813B2
公开(公告)日：2012-12-25
申请号：US12210829
申请日：2008-09-15
申请人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammad Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
IPC分类号： A61B5/055
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
摘要翻译： 本发明一般涉及多模式磁共振成像（MRI）造影剂。 特别地，本发明提供了构造成操纵周围水质子旋转的纵向（T1）和横向（T2）弛豫时间的MRI造影剂。
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公开(公告)号：US20130108554A1
公开(公告)日：2013-05-02
申请号：US13720160
申请日：2012-12-19
申请人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
发明人： Elise A. Schultz Sikma , Mohammed Aslam , Vinayak P. Dravid , Thomas J. Meade , Bradley D. Ulrich
CPC分类号： A61K49/14 , A61B5/055 , A61B5/416 , A61K49/085 , A61K49/1824 , A61K49/183 , A61K49/186 , B82Y5/00 , Y10S977/773 , Y10S977/811 , Y10S977/838 , Y10S977/93
摘要： The present invention relates generally to multimodal magnetic resonance imaging (MRI) contrast agents. In particular, the present invention provides a MRI contrast agent configured to manipulate both the longitudinal (T1) and transverse (T2) relaxation times of surrounding water proton spins.
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公开(公告)号：US08834840B1
公开(公告)日：2014-09-16
申请号：US11906825
申请日：2007-10-04
申请人： Steve R. Bull , Thomas J. Meade , Samuel I. Stupp
发明人： Steve R. Bull , Thomas J. Meade , Samuel I. Stupp
CPC分类号： A61K38/07 , A61K38/03 , A61K49/103 , A61K49/105 , A61K49/108 , C07K7/06 , G01R33/5601
摘要： Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.
摘要翻译： 包含可用于一系列磁共振成像应用的包含一种或多种造影剂的肽两亲物化合物的组合物和/或混合物。
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公开(公告)号：US08802390B2
公开(公告)日：2014-08-12
申请号：US13353001
申请日：2012-01-18
申请人： Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
发明人： Paul A. Bertin , Michael Ahrens , Dimitra Georganopoulou , Harry B. Gray , Thomas J. Meade , Markus Franz Wunder
IPC分类号： C12Q1/37
CPC分类号： G01N27/30 , C12Q1/003 , C12Q1/37 , C12Q1/485 , Y10T29/49117
摘要： The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, λ, of an electron transfer process.
摘要翻译： 本发明涉及使用电子转移过程的核重组能量λ检测酶的新型组合物和方法。
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公开(公告)号：US20130303737A1
公开(公告)日：2013-11-14
申请号：US13861011
申请日：2013-04-11
CPC分类号： C07K19/00 , A61K31/7135 , C07H23/00
摘要： The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targeted proteins, methods of synthesis thereof, and pharmaceutical compositions and uses thereof.
摘要翻译： 本发明提供目标希夫碱配合物。 特别地，本发明提供了配置成抑制靶向蛋白质活性的生物聚合物靶向过渡金属络合物，其合成方法及其药物组合物及其用途。
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公开(公告)号：US20120199499A1
公开(公告)日：2012-08-09
申请号：US13366068
申请日：2012-02-03
IPC分类号： G01N27/26
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US07601507B2
公开(公告)日：2009-10-13
申请号：US11981645
申请日：2007-10-30
IPC分类号： G01N33/53
CPC分类号： G01N27/3277 , B82Y15/00 , B82Y30/00 , G01N33/5438 , G01N33/58 , G01N33/84 , G01N2458/30 , G01N2800/04
摘要： The present invention is directed to the detection of target analytes using electronic techniques, particularly AC techniques.
摘要翻译： 本发明涉及使用电子技术，特别是AC技术检测目标分析物。
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公开(公告)号：US07595153B2
公开(公告)日：2009-09-29
申请号：US11980203
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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公开(公告)号：US07582419B2
公开(公告)日：2009-09-01
申请号：US11978930
申请日：2007-10-30
申请人： Thomas J. Meade
发明人： Thomas J. Meade
CPC分类号： B82Y30/00 , B82Y5/00 , B82Y15/00 , G01N33/542 , G01N33/5438
摘要： The invention relates to novel methods and compositions for the detection of analytes using the nuclear reorganization energy, λ, of an electron transfer process.
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