公开(公告)号：US08384053B2

公开(公告)日：2013-02-26

申请号：US13023394

申请日：2011-02-08

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce betatron oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束提取方法和装置。 该系统使用射频（RF）空腔系统来诱导带电粒子流的贝塔振荡。 带电粒子流的足够的幅度调制导致带电粒子流撞击诸如箔的材料。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，以允许从原始带电粒子流物理分离还原能带电粒子流。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US20120209109A1

公开(公告)日：2012-08-16

申请号：US13398446

申请日：2012-02-16

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61B6/00 ,  A61B6/03

CPC classification number: A61N5/1064 ,  A61B6/032 ,  A61B6/0421 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/107 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/1097

Abstract: The invention comprises an X-ray tomography method and apparatus used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. In various embodiments, 3-D images are generated from a series of 2-D X-rays images; the X-ray source and detector are stationary while the patient rotates; the 2-D X-ray images are generated using an X-ray source proximate a charged particle beam in a charged particle cancer therapy system; and the X-ray tomography system uses an electron source having a geometry that enhances an electron source lifetime, where the electron source is used in generation of X-rays. The X-ray tomography system is optionally used in conjunction with systems used to both move and constrain movement of the patient, such as semi-vertical, sitting, or laying positioning systems. The X-ray images are optionally used in control of a charged particle cancer therapy system.

Abstract translation: 本发明包括与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用的X射线断层摄影方法和装置。 在各种实施例中，从一系列2-D X射线图像生成3-D图像; X射线源和检测器在患者旋转时是静止的; 使用在带电粒子癌症治疗系统中的带电粒子束附近的X射线源产生2-D X射线图像; 并且X射线断层摄影系统使用具有增强电子源寿命的几何形状的电子源，其中电子源用于产生X射线。 X射线断层摄影系统可选地与用于移动和约束患者运动的系统结合使用，例如半垂直，坐着或铺设定位系统。 X射线图像任选用于控制带电粒子癌症治疗系统。

公开(公告)号：US08198607B2

公开(公告)日：2012-06-12

申请号：US12614733

申请日：2009-11-09

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H7/10 ,  A61N2005/1087 ,  H01J3/04 ,  H01J3/14 ,  H05H5/06 ,  H05H13/04

Abstract: The invention comprises a tandem accelerator method and apparatus, which is part of an ion beam injection system used in conjunction with multi-axis charged particle radiation therapy of cancerous tumors. The negative ion beam source includes an injection system vacuum system and a synchrotron vacuum system separated by a foil, where negative ions are converted to positive ions. The foil is sealed to the edges of the vacuum tube providing for a higher partial pressure in the injection system vacuum chamber and a lower pressure in the synchrotron vacuum system. Having the foil physically separating the vacuum chamber into two pressure regions allows for fewer and/or smaller pumps to maintain the lower pressure system in the synchrotron as the inlet hydrogen gas is extracted in a separate contained and isolated space by the injection partial vacuum system.

Abstract translation: 本发明包括串联加速器方法和装置，其是与癌性肿瘤的多轴带电粒子放射治疗结合使用的离子束注射系统的一部分。 负离子束源包括注射系统真空系统和由箔分离的同步加速器真空系统，其中负离子转化为正离子。 箔片密封到真空管的边缘，在注射系统真空室中提供较高的分压，并且在同步加速器真空系统中具有较低的压力。 将真空室物理分离成两个压力区域的箔允许更少和/或更小的泵维持同步加速器中的较低压力系统，因为入口氢气通过注射部分真空系统在单独的包含和隔离的空间中提取。

公开(公告)号：US20120143051A1

公开(公告)日：2012-06-07

申请号：US13360683

申请日：2012-01-28

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61B6/00 ,  H01J3/14 ,  H01J3/26 ,  B01J19/08

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过使用用于监测和/或控制患者呼吸的反馈传感器与患者呼吸配合的多场成像和/或多场带电粒子癌治疗方法和装置。 优选地，多场成像，例如X射线成像和带电粒子治疗在部分固定和可重新定位的位置上对患者进行。 通过控制带电粒子束注射，加速，提取和/或靶向方法和装置，将X射线和/或质子传递定时到患者呼吸。

公开(公告)号：US08129699B2

公开(公告)日：2012-03-06

申请号：US12464816

申请日：2009-05-12

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H05H13/04 ,  A61N5/1049 ,  A61N5/1067 ,  A61N2005/1059 ,  A61N2005/1061 ,  A61N2005/1087

Abstract: The invention relates generally to treatment of solid cancers. More particularly, the invention relates to a multi-field imaging and/or a multi-field charged particle cancer therapy method and apparatus coordinated with patient respiration via use of feedback sensors used to monitor and/or control patient respiration. Preferably, the multi-field imaging, such as X-ray imaging, and the charged particle therapy are performed on a patient in a partially immobilized and repositionable position. X-ray and/or proton delivery is timed to patient respiration via control of charged particle beam injection, acceleration, extraction, and/or targeting methods and apparatus.

Abstract translation: 本发明一般涉及固体癌的治疗。 更具体地，本发明涉及通过使用用于监测和/或控制患者呼吸的反馈传感器与患者呼吸配合的多场成像和/或多场带电粒子癌治疗方法和装置。 优选地，多场成像，例如X射线成像和带电粒子治疗在部分固定和可重新定位的位置上对患者进行。 通过控制带电粒子束注射，加速，提取和/或靶向方法和装置，将X射线和/或质子传递定时到患者呼吸。

公开(公告)号：US08129694B2

公开(公告)日：2012-03-06

申请号：US12571589

申请日：2009-10-01

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: H01J3/04 ,  A61N2005/1087 ,  H01J27/028 ,  H05H7/04 ,  H05H13/04

Abstract: The invention comprises a negative ion beam source vacuum method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The negative ion beam source contains a vacuum chamber isolated by a vacuum barrier from the vacuum tube of the synchrotron. The negative ion beam source vacuum system preferably includes: a first pump turbo molecular pump, a large holding volume, and a semi-continuously operating pump. By only pumping ion beam source vacuum chamber and by only semi-continuously operating the ion beam source vacuum based on sensor readings about the holding volume, the lifetime of the semi-continuously operating pump is extended.

Abstract translation: 本发明包括负离子束源真空方法和用作离子束注入系统的一部分的装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 负离子束源包含由真空隔离层从同步加速器的真空管隔离的真空室。 负离子束源真空系统优选包括：第一泵涡轮分子泵，大保持体积和半连续运行的泵。 通过仅泵浦离子束源真空室，并且仅基于关于保持体积的传感器读数半连续地操作离子束源真空，半连续操作泵的寿命延长。

公开(公告)号：US20120041251A1

公开(公告)日：2012-02-16

申请号：US13214065

申请日：2011-08-19

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: A61N5/00

CPC classification number: A61N5/00 ,  H05K999/00

Abstract: The invention comprises an X-ray method and apparatus used in conjunction with charged particle or proton beam radiation therapy of cancerous tumors. The system uses an X-ray beam that lies in substantially the same path as a proton beam path of a particle beam cancer therapy system. The system creates an electron beam that strikes an X-ray generation source where the X-ray generation source is located proximate to the proton beam path. By generating the X-rays near the proton beam path, an X-ray path that is essentially the proton beam path is created. Using the generated X-rays, the system collects X-ray images of a localized body tissue region about a cancerous tumor. The generated image is usable for: fine tuning body alignment relative to the proton beam path, to control the proton beam path to accurately and precisely target the tumor, and/or in system verification and validation.

Abstract translation: 本发明包括与癌性肿瘤的带电粒子或质子束放射治疗结合使用的X射线方法和装置。 该系统使用位于与粒子束癌治疗系统的质子束路径基本相同的路径上的X射线束。 该系统产生电子束，该电子束撞击X射线产生源，其中X射线产生源位于质子束路径附近。 通过在质子束路径附近产生X射线，产生基本上是质子束路径的X射线路径。 使用生成的X射线，系统收集关于癌性肿瘤的局部的身体组织区域的X射线图像。 生成的图像可用于：相对于质子束路径精细调整身体对准，以控制质子束路径以准确且精确地靶向肿瘤，和/或在系统验证和验证中。

公开(公告)号：US08093564B2

公开(公告)日：2012-01-10

申请号：US12564367

申请日：2009-09-22

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: G21K1/087

CPC classification number: A61N5/10 ,  A61N5/1082 ,  A61N2005/1087 ,  G21K1/08 ,  H05H7/10 ,  H05H13/04

Abstract: The invention comprises an ion beam focusing method and apparatus used as part of an ion beam injection system, which is used in conjunction with multi-axis charged particle or proton beam radiation therapy of cancerous tumors. The ion beam focusing system includes two or more electrodes where one electrode of each electrode pair partially obstructs the ion beam path with conductive paths, such as a conductive mesh. In a given electrode pair, electric field lines, running between the conductive mesh of a first electrode and a second electrode, provide inward forces focusing the negative ion beam. Multiple such electrode pairs provide multiple negative ion beam focusing regions.

Abstract translation: 本发明包括用作离子束注入系统的一部分的离子束聚焦方法和装置，其与多轴带电粒子或癌肿瘤的质子束放射治疗结合使用。 离子束聚焦系统包括两个或更多个电极，每个电极对的一个电极部分地阻挡具有导电路径的离子束路径，例如导电网。 在给定的电极对中，在第一电极和第二电极的导电网之间延伸的电场线提供聚集负离子束的向内的力。 多个这样的电极对提供多个负离子束聚焦区域。

公开(公告)号：US20110174984A1

公开(公告)日：2011-07-21

申请号：US13023394

申请日：2011-02-08

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J1/50 ,  H01J3/14

CPC classification number: H05H7/10 ,  A61N5/10 ,  A61N2005/1087 ,  H05H13/04

Abstract: The invention comprises a charged particle beam extraction method and apparatus used in conjunction with charged particle beam radiation therapy of cancerous tumors. The system uses a radio-frequency (RF) cavity system to induce betatron oscillation of a charged particle stream. Sufficient amplitude modulation of the charged particle stream causes the charged particle stream to hit a material, such as a foil. The foil decreases the energy of the charged particle stream, which decreases a radius of curvature of the charged particle stream in the synchrotron sufficiently to allow a physical separation of the reduced energy charged particle stream from the original charged particle stream. The physically separated charged particle stream is then removed from the system by use of an applied field and deflector.

Abstract translation: 本发明包括与癌肿瘤的带电粒子束放射治疗结合使用的带电粒子束提取方法和装置。 该系统使用射频（RF）空腔系统来诱导带电粒子流的贝塔振荡。 带电粒子流的足够的幅度调制导致带电粒子流撞击诸如箔的材料。 箔片降低了带电粒子流的能量，这减少了同步加速器中的带电粒子流的曲率半径，以允许从原始带电粒子流物理分离还原能带电粒子流。 然后通过使用施加的场和偏转器将物理分离的带电粒子流从系统中移除。

公开(公告)号：US20110147608A1

公开(公告)日：2011-06-23

申请号：US13033293

申请日：2011-02-23

Applicant: Vladimir Balakin

Inventor： Vladimir Balakin

IPC: H01J3/14 ,  A61B6/04 ,  A61B6/03 ,  A61N5/10

CPC classification number: A61N5/1049 ,  A61N5/10 ,  A61N5/1064 ,  A61N2005/1087 ,  H05H7/10 ,  H05H13/04

Abstract: The invention relates to a method and apparatus for treatment of a solid tumor. More particularly, the invention comprises a multi-axis and/or multi-field charged particle cancer therapy system. In one embodiment, the tumor is imaged from multiple directions in phase with patient respiration. The two-dimensional images are combined to produce a three-dimensional picture of the tumor relative to patient features. The resulting three-dimensional image is used in generation of a radiation treatment plan and subsequent radiation therapy with the radiation beam in terms of control of two-dimensional beam trajectory, delivered beam energy, delivered beam intensity, and/or beam velocity each as a function of patient vertical translation position, patient rotation position, and/or patient respiration.

Abstract translation: 本发明涉及一种治疗实体瘤的方法和装置。 更具体地，本发明包括多轴和/或多场带电粒子癌症治疗系统。 在一个实施方案中，肿瘤与患者呼吸同时从多个方向成像。 组合二维图像以产生相对于患者特征的肿瘤的三维图像。 所产生的三维图像用于产生放射治疗计划和随后用辐射束进行的辐射治疗，就控制二维束轨迹，递送的束能量，递送的束强度和/或束速度而言 患者垂直平移位置，患者旋转位置和/或患者呼吸的功能。