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公开(公告)号：US08972228B2
公开(公告)日：2015-03-03
申请号：US13462480
申请日：2012-05-02
IPC分类号： G06G7/48 , A61B5/0408 , A61B5/0452 , A61B5/05 , A61B5/02 , A61B5/0402 , A61N1/04 , A61N1/362 , A61N1/368
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译： 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。
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公开(公告)号：US08682436B2
公开(公告)日：2014-03-25
申请号：US13336113
申请日：2011-12-23
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3702
摘要： A method for selecting a target vein for left ventricular lead placement for cardiac resynchronization therapy includes determining electrical dispersion for the first coronary vein by calculating the difference between (i) activation time at a location of the vein that has the latest activation time of a plurality of locations in the vein and (ii) activation time at a location that has the earliest activation time of the plurality of locations. The method may further include (ii) determining whether the magnitude of the electrical dispersion for the vein meets or exceeds a predetermined threshold selecting the vein if the vein meets or exceeds the predetermined threshold; or (ii) selecting, among several veins, the vein that has the highest electrical dispersion.
摘要翻译： 用于选择用于心脏再同步治疗的左心室引导放置的目标静脉的方法包括通过计算（i）静脉位置处的激活时间之间的差异来确定第一冠状静脉的电离散，所述差异具有多个 静脉中的位置和（ii）在多个位置具有最早激活时间的位置处的激活时间。 该方法还可以包括（ii）确定静脉的电色差的大小是否满足或超过预定阈值，如果静脉达到或超过预定阈值则选择静脉; 或（ii）在几条静脉中选择具有最高电色差的静脉。
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公开(公告)号：US20130165986A1
公开(公告)日：2013-06-27
申请号：US13336113
申请日：2011-12-23
IPC分类号： A61N1/372
CPC分类号： A61N1/3627 , A61N1/3684 , A61N1/3702
摘要： A method for selecting a target vein for left ventricular lead placement for cardiac resynchronization therapy includes determining electrical dispersion for the first coronary vein by calculating the difference between (i) activation time at a location of the vein that has the latest activation time of a plurality of locations in the vein and (ii) activation time at a location that has the earliest activation time of the plurality of locations. The method may further include (ii) determining whether the magnitude of the electrical dispersion for the vein meets or exceeds a predetermined threshold selecting the vein if the vein meets or exceeds the predetermined threshold; or (ii) selecting, among several veins, the vein that has the highest electrical dispersion.
摘要翻译： 用于选择用于心脏再同步治疗的左心室引导放置的目标静脉的方法包括通过计算（i）静脉位置处的激活时间之间的差异来确定第一冠状静脉的电离散，所述差异具有多个 静脉中的位置和（ii）在多个位置具有最早激活时间的位置处的激活时间。 该方法还可以包括（ii）确定静脉的电色差的大小是否满足或超过预定阈值，如果静脉达到或超过预定阈值则选择静脉; 或（ii）在几条静脉中选择具有最高电色差的静脉。
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公开(公告)号：US20120284003A1
公开(公告)日：2012-11-08
申请号：US13462480
申请日：2012-05-02
CPC分类号： A61B5/04012 , A61B5/02 , A61B5/0402 , A61B5/04085 , A61B5/044 , A61B5/0452 , A61B5/05 , A61B5/742 , A61N1/0476 , A61N1/0484 , A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： Techniques for evaluating cardiac electrical dyssynchrony are described. In some examples, an activation time is determined for each of a plurality of torso-surface potential signals. The dispersion or sequence of these activation times may be analyzed or presented to provide variety of indications of the electrical dyssynchrony of the heart of the patient. In some examples, the locations of the electrodes of the set of electrodes, and thus the locations at which the torso-surface potential signals were sensed, may be projected on the surface of a model torso that includes a model heart. The inverse problem of electrocardiography may be solved to determine electrical activation times for regions of the model heart based on the torso-surface potential signals sensed from the patient.
摘要翻译： 描述了评估心脏电气不同步的技术。 在一些示例中，为多个躯干表面电位信号中的每一个确定激活时间。 可以分析或呈现这些激活时间的分散或序列以提供患者心脏的电不同步的各种指征。 在一些示例中，电极组的电极的位置以及因此感测躯干表面电位信号的位置可以投影在包括模型心脏的模型躯干的表面上。 可以基于从患者感测到的躯干表面电位信号来解决心电图的逆问题，以确定模型心脏区域的电激活时间。
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65.发明申请公开(公告)号：US20120004515A1
公开(公告)日：2012-01-05
申请号：US12826880
申请日：2010-06-30
申请人： Jian Cao , Jeffrey M. Gillberg
发明人： Jian Cao , Jeffrey M. Gillberg
CPC分类号： A61N1/3704 , A61B5/7203 , A61N1/3962
摘要： An implantable medical device uses an implantable sensor for acquiring a physiological signal that is received by a digital signal processor. The digital signal processor is a multi-channel signal processor including a first signal processing channel having a first sensitivity for sensing the physiological signal and a second signal processing channel having a second sensitivity different than the first sensitivity for sensing the physiological signal.
摘要翻译： 可植入医疗装置使用可植入传感器来获取由数字信号处理器接收的生理信号。 数字信号处理器是包括具有用于感测生理信号的第一灵敏度的第一信号处理通道和具有与用于感测生理信号的第一灵敏度不同的第二灵敏度的第二信号处理通道的多通道信号处理器。
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公开(公告)号：US08064996B2
公开(公告)日：2011-11-22
申请号：US11866700
申请日：2007-10-03
IPC分类号： A61N1/39
CPC分类号： A61N1/3987 , A61N1/385 , A61N1/3943 , A61N1/3962
摘要： A method and apparatus for determining a T-wave shock interval sense a cardiac electrogram (EGM) signal comprising a T-wave signal. A T-wave center is determined from the EGM signal, and a T-wave shock interval is determined in response to determining the T-wave center. A T-wave shock is delivered at the T-wave shock interval computed based on the T-wave center.
摘要翻译： 一种用于确定T波冲击间隔的方法和装置，其感测包括T波信号的心电图（EGM）信号。 从EGM信号确定T波中心，并且响应于确定T波中心来确定T波冲击间隔。 在基于T波中心计算出的T波冲击时间间隔内传递T波冲击。
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67.发明授权Method and apparatus for generating a template for arrhythmia detection and electrogram morphology classification 有权用于产生心律失常检测和电描记图形态分类的模板的方法和装置公开(公告)号：US07826893B2
公开(公告)日：2010-11-02
申请号：US11757495
申请日：2007-06-04
申请人： Jian Cao , Jeffrey M. Gillberg , Chris J. Gennaro
发明人： Jian Cao , Jeffrey M. Gillberg , Chris J. Gennaro
IPC分类号： A61B5/04 , A61B5/0472
CPC分类号： A61B5/7264 , A61B5/04525 , A61B5/0464 , A61B5/726 , A61N1/3622 , A61N1/3956
摘要： An implantable medical device and associated method for automatically generating morphology templates during fast cardiac rhythms, confirming a provisional template as a confirmed template, and using the confirmed template to classify subsequent detected arrhythmias. A provisional SVT template may be created during a fast ventricular rate and activated as a confirmed SVT template upon verification that the fast rate was due to an SVT. The confirmed SVT template may be used to discriminate SVT from VT/VF.
摘要翻译： 一种用于在快速心脏节律期间自动生成形态学模板的可植入医疗装置和相关联的方法，确认临时模板作为确认的模板，并使用确认的模板来分类随后检测的心律失常。 可以在快速心室率期间创建临时SVT模板，并且在验证快速率是由于SVT引起的情况下被激活为确认的SVT模板。 可以使用确认的SVT模板来区分SVT与VT / VF。
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公开(公告)号：US20080082014A1
公开(公告)日：2008-04-03
申请号：US11537171
申请日：2006-09-29
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/7225 , A61B5/7264 , A61N1/3704
摘要： An implantable medical device system and method detect oversensing of cardiac signals. A cardiac signal including first events and second events is acquired. Cardiac events are sensed in response to the cardiac signal crossing a first threshold. A filtered cardiac signal is determined from the sensed cardiac signal, and a second threshold is determined from the filtered cardiac signal. A sensed cardiac event is classified either as a first event when the sensed cardiac event corresponds to a filtered cardiac signal peak crossing the second threshold or a second event when the sensed cardiac event corresponds to a filtered cardiac signal peak being less than the second threshold. Classification of sensed cardiac events as second events is used in determining oversensing.
摘要翻译： 可植入医疗装置系统和方法检测心脏信号的过度感知。 获取包括第一事件和第二事件的心脏信号。 响应于穿过第一阈值的心脏信号感测心脏事件。 从感测到的心脏信号确定滤波的心脏信号，并且从滤波的心脏信号确定第二阈值。 感测的心脏事件被分类为当感测的心脏事件对应于穿过第二阈值的经滤波的心脏信号峰值时的第一事件或当感测到的心脏事件对应于小于第二阈值的经过滤的心脏信号峰值时的第二事件。 感测心脏事件作为第二次事件的分类用于确定过敏。
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69.发明授权Secure and efficacious therapy delivery for an extra-systolic stimulation pacing engine 有权安全有效的治疗输精管收缩期刺激起搏引擎公开(公告)号：US07233824B2
公开(公告)日：2007-06-19
申请号：US10703956
申请日：2003-11-07
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译： 收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。 这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 本发明涉及治疗递送指导和改善ESS治疗递送的选择。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。
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70.发明授权Detection of supraventricular tachycardia with 1:1 atrial to ventricular conduction 有权检测室性心律不齐与1：1心房与心室传导公开(公告)号：US06980860B2
公开(公告)日：2005-12-27
申请号：US10284874
申请日：2002-10-31
IPC分类号： A61N1/362
CPC分类号： A61N1/3622
摘要： The invention is directed to method and process for discriminating supraventricular tachycardia (SVT) with 1:1 atrial to ventricular conduction (AV conduction). Upon detection of a rapid heart rate, an implanted medical device may determine whether the rhythm exhibits insufficient evidence of sinus tachycardia, whether the rhythm exhibits 1:1 conduction, and whether an electrical signal corresponding to the rhythm exhibits a normal morphology. When these tests have been satisfied, the device determines that an SVT with 1:1 AV conduction has been detected.
摘要翻译： 本发明涉及用1：1心房至室性传导（AV传导）鉴别室上性心动过速（SVT）的方法和过程。 在检测到快速心率时，植入的医疗装置可以确定节律是否表现出窦性心动过速的证据不足，节律是否表现出1:1的传导以及对应于节律的电信号是否呈现正常的形态。 当满足这些测试时，该装置确定检测到具有1：1 AV导通的SVT。
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