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1.发明授权Secure and efficacious therapy delivery for an extra-systolic stimulation pacing engine 有权安全有效的治疗输精管收缩期刺激起搏引擎公开(公告)号：US07233824B2
公开(公告)日：2007-06-19
申请号：US10703956
申请日：2003-11-07
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： An extra-systolic stimulation (ESS) therapy addresses cardiac dysfunction including heart failure. ESS therapy employs atrial and/or ventricular extra-systoles via pacing-level stimulation to a heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). The present invention relates to therapy delivery guidance and options for improved ESS therapy delivery. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译： 收缩期刺激（ESS）治疗涉及心脏功能障碍，包括心力衰竭。 ESS治疗通过对心脏的起搏水平刺激使用心房和/或心室超心动过速。 这些额外的收缩期必须正确定时，以达到对心肌力学（功效）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 本发明涉及治疗递送指导和改善ESS治疗递送的选择。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。
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公开(公告)号：US09101772B2
公开(公告)日：2015-08-11
申请号：US12633893
申请日：2009-12-09
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： A method of stimulation therapy and an apparatus for providing the therapy which addresses cardiac dysfunction including heart failure. The therapy employs atrial pacing pulses delivered to a heart after the atrial refractory period and timed so that they will not cause a ventricular contraction. These atrial pacing are timed to achieve beneficial effects on myocardial mechanics (efficacy) while maintaining an extremely low level of risk of arrhythmia induction. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译： 刺激疗法的方法和用于提供包括心力衰竭在内的心脏功能障碍的治疗的装置。 该疗法使用心房起搏脉搏在心房不应期后输送到心脏并且定时，使得它们不会引起心室收缩。 这些心房起搏的时间是为了获得对心肌力学（功效）的有益影响，同时保持心律失常诱导的极低水平的风险。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。
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公开(公告)号：US20120303084A1
公开(公告)日：2012-11-29
申请号：US13569523
申请日：2012-08-08
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译： 据信上述方法和装置对于患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益 被指示。 应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。 本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。
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公开(公告)号：US20100152804A1
公开(公告)日：2010-06-17
申请号：US12633893
申请日：2009-12-09
申请人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
发明人： Karen J. Kleckner , Kathleen A. Prieve , Jeffrey M. Gillberg , Ren Zhou , Kenneth M. Anderson , D. Curtis Deno , Glenn C. Zillmer , Ruth N. Klepfer , Vincent E. Splett , David E. Euler , Lawrence J. Mulligan , Edwin G. Duffin , David A. Igel , John E. Burnes
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/36114 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/36585 , A61N1/3684 , A61N1/3962
摘要： The above-described methods and apparatus are believed to be of particular benefit for patients suffering heart failure including cardiac dysfunction, chronic HF, and the like and all variants as described herein and including those known to those of skill in the art to which the invention is directed. It will understood that the present invention offers the possibility of monitoring and therapy of a wide variety of acute and chronic cardiac dysfunctions. The current invention provides systems and methods for delivering therapy for cardiac hemodynamic dysfunction via the innervated myocardial substrate receives one or more discrete pulses of electrical stimulation during the refractory period of said innervated myocardial substrate.
摘要翻译： 据信上述方法和装置对于患有心力衰竭，包括心脏功能障碍，慢性HF等的患者以及本文所述的所有变体以及包括本发明的本领域技术人员已知的那些的患者特别有益 被指示。 应当理解，本发明提供监测和治疗各种急性和慢性心脏功能障碍的可能性。 本发明提供了用于通过所述神经支配的心肌底物递送治疗心脏血液动力学功能障碍的系统和方法，在所述神经支配的心肌基质的不应期期间接收电刺激的一个或多个离散脉冲。
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5.发明授权Cardiac pacing modality having improved blanking, timing, and therapy delivery methods for extra-systolic stimulation pacing therapy 有权心脏起搏模式具有改善的消隐，时机和治疗收费刺激起搏治疗方法公开(公告)号：US07142916B2
公开(公告)日：2006-11-28
申请号：US10692990
申请日：2003-10-24
申请人： D. Curtis Deno , Vincent E. Splett , Jeffrey M. Gillberg , Glenn C. Zillmer , Ruth N. Klepfer , Karen J. Kleckner
发明人： D. Curtis Deno , Vincent E. Splett , Jeffrey M. Gillberg , Glenn C. Zillmer , Ruth N. Klepfer , Karen J. Kleckner
IPC分类号： A61N1/36
CPC分类号： A61N1/365 , A61N1/3627
摘要： The present invention relates to the secure delivery of an extra-systolic stimulation (ESS) therapy to treat cardiac dysfunction that employs atrial and/or ventricular extra-systoles via pacing-like stimulation of the heart. These extra-systoles must be timed correctly to achieve beneficial effects on myocardial mechanics (benefit) while maintaining an extremely low level of risk of arrhythmia induction and excellent ICD-like arrhythmia sensing and detection (security). Further experience with ESS has led to improved implementation methods that depend on better blanking, ESS stimulation timing (of an “extra-systolic interval” or ESI), and ESS therapy delivery options and guidance. These methods may be employed individually or in combinations in an external or implantable ESS therapy delivery device.
摘要翻译： 本发明涉及一种收缩期刺激（ESS）疗法的安全递送，以治疗心脏功能障碍，其通过心脏起搏样刺激使用心房和/或心室外的心脏。 这些额外的收缩期必须正确定时，以获得对心肌力学（益处）的有益影响，同时保持心律失常诱导和优异的ICD样心律失常感知和检测（安全性）的极低水平的风险。 ESS的进一步经验导致改进的实施方法取决于更好的消隐，ESS刺激时间（“收缩期间期”或ESI）和ESS治疗递送选项和指导。 这些方法可以在外部或可植入的ESS治疗递送装置中单独使用或组合使用。
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公开(公告)号：US07519424B2
公开(公告)日：2009-04-14
申请号：US11342734
申请日：2006-01-30
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
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公开(公告)号：US20100137936A1
公开(公告)日：2010-06-03
申请号：US12622221
申请日：2009-11-19
IPC分类号： A61N1/378
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。
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公开(公告)号：US07616992B2
公开(公告)日：2009-11-10
申请号：US11342948
申请日：2006-01-30
IPC分类号： A61N1/36
CPC分类号： A61N1/372 , A61N1/025 , A61N1/362 , A61N1/37205 , A61N1/37229 , A61N1/375 , A61N1/3968
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
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公开(公告)号：US20090198295A1
公开(公告)日：2009-08-06
申请号：US12423605
申请日：2009-04-14
CPC分类号： A61N1/372 , A61N1/37205
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。
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公开(公告)号：US08078279B2
公开(公告)日：2011-12-13
申请号：US12622221
申请日：2009-11-19
CPC分类号： A61N1/056 , A61N1/057 , A61N1/37205 , A61N1/375 , A61N1/3785 , A61N1/3787
摘要： An implantable medical device is configured so that all of the major components including a housing and attached leads are disposed within the vasculature of a patient. A tether extends from the housing of the device to an implant location where the tether is secured to tissue outside of the vasculature. In this manner, an intravascular medical device may be implanted at a location remote from final placement, delivered via the vasculature and anchored at the initial entry point.
摘要翻译： 可植入医疗装置被构造成使得包括壳体和附接的引线的所有主要部件被布置在患者的脉管系统内。 系绳从装置的壳体延伸到植入位置，其中系绳固定到脉管系统外部的组织。 以这种方式，血管内医疗装置可以植入远离最终放置的位置，通过脉管系统递送并锚定在初始入口处。
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