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61.发明授权Closed loop cardiac resynchronization therapy using cardiac activation sequence information 有权闭环心脏再同步治疗使用心脏激活序列信息公开(公告)号：US07457664B2
公开(公告)日：2008-11-25
申请号：US11125068
申请日：2005-05-09
申请人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
发明人： Yi Zhang , Yinghong Yu , Aaron R. McCabe , Jiang Ding , Jeffrey E. Stahmann , Carlos Alberto Ricci , Scott A. Meyer
IPC分类号： A61N1/365
CPC分类号： A61N1/3712 , A61N1/3627 , A61N1/365 , G06F19/00
摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.
摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离用于使用心脏激活序列信息来检测，监测，跟踪和/或趋向闭环心脏再同步治疗。 设备和方法包括使用多个电极感测多个复合心脏信号，所述电极被配置用于植入患者体内。 使用所感测的多个复合心脏信号进行源分离，产生与一个或多个心脏激活序列的全部或一部分相关联的一个或多个心脏信号载体。 使用一个或多个心脏信号向量和与一个或多个心脏信号载体相关联的信号中的一个或两个来调整心脏再同步治疗。 在另外的实施方案中，心脏再同步治疗可以被启动，终止，或者可以改变再同步治疗的一个或多个参数。
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公开(公告)号：US20080269827A1
公开(公告)日：2008-10-30
申请号：US12169432
申请日：2008-07-08
IPC分类号： A61N1/08
摘要： Systems, devices and methods are provided for displaying statistical distributions of cardiac events. A device embodiment comprises circuitry adapted to communicate with a medical device that is adapted to acquire data regarding cardiac events occurring at two or more cardiac sites, and display means for displaying a histogram of the data as two or more statistical distributions for the two or more cardiac sites. The histogram includes a number of histogram bins. At least one of the histogram bins includes both a representation for at least a portion of a statistical distribution of a cardiac event for a first cardiac site and a representation for at least a portion of a statistical distribution of a cardiac event for a second cardiac site. Other embodiments are provided herein.
摘要翻译： 提供系统，设备和方法来显示心脏事件的统计分布。 设备实施例包括适于与适于获取关于在两个或更多个心脏部位发生的心脏事件的数据的医疗设备通信的电路，以及用于将数据的直方图显示为两个或更多个的两个或多个统计分布的显示装置 心脏部位。 直方图包括多个柱状图仓。 直方图箱中的至少一个包括用于第一心脏位点的心脏事件的统计分布的至少一部分的表示和用于第二心脏位点的心脏事件的统计分布的至少一部分的表示 。 本文提供了其他实施例。
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公开(公告)号：US20080262360A1
公开(公告)日：2008-10-23
申请号：US11736058
申请日：2007-04-17
IPC分类号： A61B5/0205
CPC分类号： A61B5/0205 , A61B5/0816 , A61B5/1116 , A61B5/4818 , A61B5/686 , A61N1/3627
摘要： Systems and methods for diagnosing one or more respiration distress manifestations by implantably recognizing their occurrence and evaluating information about the same to provide an indication of present or impending worsening heart failure are discussed. Using information produced by an implantable respiration sensor circuit and an implantable physiological sensor circuit, such as at least one of a physical activity sensor circuit or a posture sensor circuit, an implantable or external processor circuit may detect a respiration disturbance and an associated subsequent arousal from stable state occurrence and thereafter evaluate over time arousal from stable state occurrences to provide the indication of present or impending worsening heart failure. In one example, information about a fluid level within a subject is used in determining the indication of worsening heart failure. In various examples, a regimen is initiated or adjusted in response to the indication of present or impending worsening heart failure.
摘要翻译： 讨论了通过可植入地识别其发生并评估关于其的信息来诊断一种或多种呼吸困扰表现的系统和方法，以提供现在或即将恶化的心力衰竭的指征。 使用由可植入呼吸传感器电路和植入式生理传感器电路产生的信息，例如物理活动传感器电路或姿势传感器电路中的至少一个，可植入或外部处理器电路可以检测呼吸障碍和相关联的随后的唤醒 稳定状态发生，然后评估来自稳定状态发生的随着时间的兴奋，以提供目前或即将恶化的心力衰竭的指征。 在一个示例中，关于受试者内的液位水平的信息用于确定恶化的心力衰竭的指示。 在各种实例中，响应于目前或即将恶化的心力衰竭的指征开始或调整方案。
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公开(公告)号：US20080243016A1
公开(公告)日：2008-10-02
申请号：US11692687
申请日：2007-03-28
CPC分类号： A61B5/0205 , A61B5/0215 , A61B5/08 , A61B5/0823 , A61B5/411 , A61B5/4806 , A61B5/4818 , A61B5/6846
摘要： Embodiments of the invention are related to methods and systems for using a pulmonary artery pressure signal to detect and/or monitor physiological parameters, physiological status, and aspects of disorders and diseases, amongst other things. In an embodiment, the invention includes a method of measuring a pulmonary function parameter of a patient. In an embodiment, the invention includes a method of detecting a sleeping disorder. In an embodiment, the invention includes a method of tracking sleep characteristics of a patient. Other aspects and embodiments are provided herein.
摘要翻译： 本发明的实施例涉及用于使用肺动脉压力信号来检测和/或监测生理参数，生理状况以及紊乱和疾病方面的方法和系统。 在一个实施例中，本发明包括测量患者的肺功能参数的方法。 在一个实施例中，本发明包括一种检测睡眠障碍的方法。 在一个实施例中，本发明包括跟踪患者的睡眠特征的方法。 本文提供了其它方面和实施例。
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65.发明授权公开(公告)号：US07403818B2
公开(公告)日：2008-07-22
申请号：US10987256
申请日：2004-11-12
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A device and method for cardiac rhythm management in which a heart chamber is paced in accordance with a pacing mode that employs sense signals from the opposite chamber. A protection period triggered by the sensing of intrinsic activity in the paced chamber is used to inhibit pacing without otherwise disturbing the pacing algorithm.
摘要翻译： 一种用于心律管理的装置和方法，其中心室根据采用来自相对室的感测信号的起搏模式而起搏。 通过感觉起搏室内部活动触发的保护期限被用于抑制起搏而不打扰起搏算法。
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公开(公告)号：US07387610B2
公开(公告)日：2008-06-17
申请号：US10921503
申请日：2004-08-19
申请人： Jeffrey E. Stahmann , John Hatlestad , Boyce Moon
发明人： Jeffrey E. Stahmann , John Hatlestad , Boyce Moon
IPC分类号： A61B5/02
CPC分类号： A61B5/053 , A61N1/3627 , A61N1/36521
摘要： This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.
摘要翻译： 本文件尤其涉及一种使用胸部阻抗来确定胸部存在多少液体的心律管理装置或其他可植入医疗装置，例如用于检测或预测充血性心力衰竭，肺水肿，胸腔积液，低血压 ，等等。 根据胸部阻抗确定的胸腔液量补偿血液电阻率的变化，这可能是血细胞比容水平的变化或其他因素引起的。 血液电阻补偿的胸腔液量可以存储在设备中或者传输到外部设备进行存储或显示。 血液电阻补偿的胸液量也可用于调整心脏起搏，心脏再同步或其他心律控制或对患者的其他治疗。 本文件还讨论了用于预测或指示贫血的装置和方法的应用。
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67.发明申请System And Method For Determining Pulmonary Performance From Transthoracic Impedance Measures 有权用于确定胸腔阻塞措施的肺功能的系统和方法公开(公告)号：US20080132802A1
公开(公告)日：2008-06-05
申请号：US12029422
申请日：2008-02-11
申请人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
发明人： Quan Ni , Jesse W. Hartley , Kent Lee , Jeffrey E. Stahmann
IPC分类号： A61B5/085
CPC分类号： A61B5/0809 , A61B5/0002 , A61B5/0535 , A61N1/36521 , G06F19/3418
摘要： A system and method for determining pulmonary performance from transthoracic impedance measures is provided. Transthoracic impedance measures collected by an implantable medical device are correlated to pulmonary functional measures. The pulmonary functional measures are grouped by respiratory pattern. Pulmonary performance is evaluated. Differences are determined by comparing the pulmonary functional measures for each respiratory pattern to the pulmonary functional measures for at least one previous respiratory pattern. A trend is identified from the differences. An alert is generated upon sufficient deviation of the trend from a threshold criteria.
摘要翻译： 提供了一种通过经胸阻抗测量来确定肺功能的系统和方法。 由可植入医疗器械收集的经胸阻抗测量与肺功能测量相关。 肺功能测量按呼吸模式分组。 评估肺功能。 通过将每个呼吸模式的肺功能测量与至少一个之前的呼吸模式的肺功能测量进行比较来确定差异。 从差异中确定出一个趋势。 在趋势与阈值标准的充分偏差之后产生警报。
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公开(公告)号：US20080125820A1
公开(公告)日：2008-05-29
申请号：US11564637
申请日：2006-11-29
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more parameters. The system alters one or more of the parameters as a function of one or more triggering events. The system then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered parameters.
摘要翻译： 根据一个或多个参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。 系统根据一个或多个触发事件改变一个或多个参数。 该系统然后根据至少一个或多个改变的参数用一个或多个可植入医疗装置感测心脏声音。
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公开(公告)号：US07379773B2
公开(公告)日：2008-05-27
申请号：US11085755
申请日：2005-03-21
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/368
摘要： A device and method for cardiac rhythm management in which a cardiac site is paced in accordance with a pacing mode that employs sense signals from a different cardiac site. A protective period triggered by the sensing of intrinsic activity at the paced site is used to delay pacing by a protective delay interval without otherwise disturbing the pacing algorithm.
摘要翻译： 心脏节律管理的装置和方法，其中心脏部位根据采用来自不同心脏部位的感测信号的起搏模式而起搏。 通过感觉起搏部位的内在活动触发的保护期用于延迟起搏保护延迟时间间隔，而不会影响起搏算法。
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公开(公告)号：US07376463B2
公开(公告)日：2008-05-20
申请号：US11169339
申请日：2005-06-29
IPC分类号： A61N1/00
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译： 一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路 和治疗电路。 控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。
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