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    Biodegradable oxidized cellulose esters and their uses as microspheres
    61.
    发明申请
    Biodegradable oxidized cellulose esters and their uses as microspheres 失效
    可生物降解的氧化纤维素酯及其用作微球体

    公开(公告)号：US20050131225A1

    公开(公告)日：2005-06-16

    申请号：US10975248

    申请日：2004-10-28

    申请人： Vijay Kumar ,  Yang Dong

    发明人： Vijay Kumar ,  Yang Dong

    IPC分类号： A61K9/16 ,  A61K9/50 ,  C08B3/00 ,  C08B15/00 ,  C08B1/00

    CPC分类号： A61K9/1652 ,  A61K9/5042 ,  C08B3/00 ,  C08B15/00

    摘要： A new cellulose excipient, OCCAE, suitable for use as a binder, filler, and/or disintegrant in the development of solid dosage forms and as a bodying agent or a drug carrier in the preparation of topical formulations is described. The cellulose excipient is formed by reacting an oxidized cellulose ester with an alcohol in the presence of a catalyst. The invention also describes the formation of controlled release microspheres using OCCAE and/or oxidized cellulose esters that may be used to control the release of drug in a patient over a time period of several hours to several days.

    摘要翻译： 描述了一种新的纤维素赋形剂OCCAE，其适于在制备固体剂型中作为粘合剂，填充剂和/或崩解剂，以及作为局部制剂制剂中的保护剂或药物载体。 纤维素赋形剂通过在催化剂存在下使氧化的纤维素酯与醇反应而形成。 本发明还描述了使用OCCAE和/或氧化的纤维素酯形成控制释放微球，其可以用于在数小时至数天的时间段内控制药物释放。

    Oxidized cellulose
    64.
    发明授权
    Oxidized cellulose 失效
    氧化纤维素

    公开(公告)号：US5414079A

    公开(公告)日：1995-05-09

    申请号：US101184

    申请日：1993-08-03

    申请人： Gilbert S. Banker ,  Vijay Kumar

    发明人： Gilbert S. Banker ,  Vijay Kumar

    IPC分类号： A61K8/73 ,  A61Q19/00 ,  C08B15/02 ,  C08B11/00

    CPC分类号： A61K8/04 ,  A61K8/731 ,  A61Q19/00 ,  C08B15/02 ,  A61Q17/04

    摘要： A method for making an oxidized cellulose product from a cellulose material is disclosed. The method involves oxidizing a cellulose material into an oxidized cellulose product, comprising treating the cellulose material with a hypochlorite solution having an active chlorine content of between about 4 and about 6%, at a pH exceeding 9.5 and at a temperature, and for a time, effective to convert the cellulose material into the oxidized cellulose product; filtering the oxidized cellulose product; and washing the oxidized cellulose product with an antichlor agent such as sodium thiosulfate to remove chlorine and to raise the oxidized cellulose product to a neutral pH.The oxidized cellulose product may be used to form films, dispersions, gels, as carriers, for pharmaceuticals, cosmetics and other products.

    摘要翻译： 公开了一种从纤维素材料制备氧化纤维素产品的方法。 该方法包括将纤维素材料氧化成氧化的纤维素产品，包括用活性氯含量为约4至约6％的次氯酸盐溶液处理纤维素材料，pH值超过9.5，并在一段时间 有效地将纤维素材料转化成氧化纤维素产品; 过滤氧化纤维素产品; 用硫代硫酸钠等抗氯剂洗涤氧化纤维素产品，除去氯，使氧化纤维素产物升至中性pH。 氧化纤维素产品可用于形成药物，化妆品和其它产品的膜，分散体，凝胶，载体。

    Crimp snap retention system
    66.
    发明授权
    Crimp snap retention system 失效
    压接卡扣保持系统

    公开(公告)号：US4749373A

    公开(公告)日：1988-06-07

    申请号：US60721

    申请日：1987-06-22

    申请人： Lawrence J. Brekosky ,  Jack S. Kissoyan ,  Vijay Kumar

    发明人： Lawrence J. Brekosky ,  Jack S. Kissoyan ,  Vijay Kumar

    IPC分类号： H01R13/42 ,  H01R13/424 ,  H01R13/40

    CPC分类号： H01R13/424

    摘要： A connector assembly (10) having an all plastic retention system has a housing (16, 18) in which tines (40) extend from a surface (36) thereof axially along contact receiving passages (38, 58). Each split frustoconical tine (40) has two tine members (42, 44). A transverse rib (54) extends along a surface (36) of the housing between adjacent tine members (42, 44) of adjacent tines (40). Each tine member (42, 44) has a pair of vertical ribs (50) extending along the exterior surface thereof upward from the surface (36) of the housing and sharing a portion of its volume with the transverse rib (54). The vertical ribs (50) and transverse rib (54) promote flow of plastic into all regions of the mould during moulding and support a contact (52) upon insertion thereof. A contact (52) inserted from the rear face (34) causes tine members (42, 44) to move radially outward until a retention bead (72) passes through an orifice (48) then tine members (42, 44) return to an unbiased position and contact (52) is secured in the connector assembly (10) as retention bead (68) is positioned between an annular shoulder (74) and the ends (46) of tine members (42, 44).

    摘要翻译： 具有全塑料保持系统的连接器组件（10）具有壳体（16,18），齿条（40）从其轴向沿着接触接收通道（38,58）的表面（36）延伸。 每个分裂截头圆锥齿（40）具有两个齿构件（42,44）。 横向肋（54）沿着相邻齿（40）的相邻齿部件（42,44）之间的壳体的表面（36）延伸。 每个齿构件（42,44）具有一对垂直肋条（50），其沿其外表面从壳体的表面（36）向上延伸，并且与横向肋条（54）共享其一部分体积。 垂直肋（50）和横向肋（54）在模制期间促进塑料流入模具的所有区域，并在其插入时支撑触点（52）。 从后表面（34）插入的接触件（52）使得齿部件（42,44）径向向外移动，直到保持凸缘（72）穿过孔口（48），然后齿部件（42,44）返回到 无偏位置和接触（52）固定在连接器组件（10）中，因为保持凸缘（68）位于环形肩部（74）和齿构件（42,44）的端部（46）之间。

    EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTIDE
    68.
    发明申请
    EUGLOBULIN-BASED METHOD FOR DETERMINING THE BIOLOGICAL ACTIVITY OF DEFIBROTIDE 有权
    基于EUGLOBULIN的方法，用于确定抗体的生物活性

    公开(公告)号：US20150176003A1

    公开(公告)日：2015-06-25

    申请号：US14408272

    申请日：2012-06-22

    申请人： Terenzio Ignoni ,  Vijay Kumar ,  Khalid Islam

    发明人： Terenzio Ignoni ,  Vijay Kumar ,  Khalid Islam

    IPC分类号： C12N15/11 ,  G01N33/86

    CPC分类号： C12N15/11 ,  A61K31/711 ,  C12N2310/127 ,  C12Q1/37 ,  C12Q1/56 ,  G01N33/86

    摘要： It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide. Liquid defibrotide formulations are also disclosed, preferably water solutions, having a defined biological activity and, in particular, having an activity of 25 to 35 IU/mg of defibrotide, preferably from 27.5 to 32.5 IU/mg and, more preferably, from 28 to 32 IU/mg.

    摘要翻译： 公开了一种用于测定去纤维蛋白酶的生物学活性的方法，其包括以下步骤：a）使脱纤维肽，哺乳动物优球蛋白和对纤溶酶特异性的底物接触，所述底物通过与纤溶酶反应提供可测量的产物; 和b）测量连续形成的产物的量，从而确定去纤维蛋白酶的生物活性。 还公开了具有限定的生物活性，特别是具有25至35IU / mg去纤维蛋白酶活性，优选27.5至32.5IU / mg的活性，更优选为28至 32 IU / mg。

    Hybrid text and image based encoding
    70.
    发明授权
    Hybrid text and image based encoding 有权
    混合文本和基于图像的编码

    公开(公告)号：US08648858B1

    公开(公告)日：2014-02-11

    申请号：US12731866

    申请日：2010-03-25

    申请人： Erik R. Swenson ,  Vijay Kumar

    发明人： Erik R. Swenson ,  Vijay Kumar

    IPC分类号： G06T17/00

    CPC分类号： G06T9/00 ,  H04N19/12 ,  H04N19/136 ,  H04N19/176 ,  H04N19/59

    摘要： A configuration for encoding and decoding the data is disclosed herein. A server retrieves webpage content to filter and extract text and image data. The text data is encoded using a lossless encoder, whereas the image data is downsampled to a lower resolution and encoded using a lossy encoder. The encoded text and image data is transmitted over a network. Once the encoded data is received on the client device, the text and image data is decoded using an inverse encoding algorithm and resized at a resolution appropriate to the native resolution of the display device.

    摘要翻译： 本文公开了用于对数据进行编码和解码的配置。 服务器检索网页内容以过滤和提取文本和图像数据。 使用无损编码器对文本数据进行编码，而将图像数据下采样到较低分辨率并使用有损编码器进行编码。 编码的文本和图像数据通过网络传输。 一旦在客户端设备上接收到编码数据，就使用逆编码算法对文本和图像数据进行解码，并以适合于显示设备的原始分辨率的分辨率进行调整。