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61.发明授权公开(公告)号：US07203540B2
公开(公告)日：2007-04-10
申请号：US10744237
申请日：2003-12-22
申请人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
发明人： Jiang Ding , Yinghong Yu , Bruce H. KenKnight
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： A method or system for computing and/or setting optimal cardiac resynchronization pacing parameters as derived from intrinsic conduction data is presented. The intrinsic conduction data includes intrinsic atrio-ventricular and interventricular delay intervals which may be collected via the sensing channels of an implantable cardiac device. Among the parameters which may be optimized in this manner are an atrio-ventricular delay interval and a biventricular offset interval. In one of its aspects, the invention provides for computing optimum pacing parameters for patients having some degree of AV block or with atrial conduction deficits. Another aspect of the invention relates to a pacing mode and configuration for providing cardiac resynchronization therapy to patients with a right ventricular conduction disorder.
摘要翻译： 提出了一种用于计算和/或设置从内在传导数据导出的最佳心脏再同步起搏参数的方法或系统。 内在传导数据包括可通过可植入心脏装置的感测通道收集的本征心室和室间延迟间隔。 可以以这种方式优化的参数是心房延迟间隔和双心室偏移间隔。 在其一个方面，本发明提供了对具有一定程度的AV阻滞或具有心房传导缺陷的患者计算最佳起搏参数。 本发明的另一方面涉及用于向患有右心室传导障碍的患者提供心脏再同步治疗的起搏模式和配置。
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62.发明授权Method for reducing arterial restenosis in the presence of an intravascular stent 失效在血管内支架存在下减少动脉再狭窄的方法公开(公告)号：US06648881B2
公开(公告)日：2003-11-18
申请号：US09940337
申请日：2001-08-27
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译： 第一电极位于植入的血管内支架附近的动脉内。 第二电极相对于第一电极的位置定位在单独的位置。 然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。 当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间 心动周期。
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63.发明授权公开(公告)号：US06640135B1
公开(公告)日：2003-10-28
申请号：US09544363
申请日：2000-04-06
IPC分类号： A61N1368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译： 一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力 。 为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。
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64.发明授权公开(公告)号：US06519488B2
公开(公告)日：2003-02-11
申请号：US09940336
申请日：2001-08-27
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
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公开(公告)号：US06453201B1
公开(公告)日：2002-09-17
申请号：US09473466
申请日：1999-12-28
IPC分类号： A61N1362
CPC分类号： A61N1/37217 , A61N1/3625 , A61N1/3627 , A61N1/37247
摘要： An implantable medical device such as a cardiac pacemaker or implantable cardioverter/defibrillator with the capability of receiving communications in the form of speech spoken by the patient. An acoustic transducer is incorporated within the device which along with associated filtering circuitry enables the voice communication to be used to affect the operation of the device or recorded for later playback.
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66.发明授权公开(公告)号：US06285909B1
公开(公告)日：2001-09-04
申请号：US09321254
申请日：1999-05-27
IPC分类号： A61N1362
CPC分类号： A61N1/37252 , A61N1/37288
摘要： A method and a system for preserving patient specific data in implantable pulse generator systems. A communication link is established with a first implantable pulse generator. Electronic cardiac data contained within the first implantable pulse generator is retrieved through the communication link. The electronic cardiac data is then electronically downloaded to a second implantable pulse generator. Prior to downloading, the electronic cardiac data can be formatted into a format compatible with the second implantable pulse generator.
摘要翻译： 一种用于在植入式脉冲发生器系统中保存患者特定数据的方法和系统。 建立与第一可植入脉冲发生器的通信链路。 通过通信链路检索包含在第一可植入脉冲发生器内的电子心脏数据。 然后将电子心脏数据电子下载到第二可植入脉冲发生器。 在下载之前，电子心脏数据可以被格式化成与第二可植入脉冲发生器兼容的格式。
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67.发明授权公开(公告)号：US06272377B1
公开(公告)日：2001-08-07
申请号：US09411345
申请日：1999-10-01
IPC分类号： A61B50468
CPC分类号： A61N1/3622 , G06F19/00 , G16H50/30
摘要： A cardiac rhythm management system predicts when an arrhythmia will occur and in one embodiment invokes a therapy to prevent or reduce the consequences of the arrhythmia. A cardiac arrhythmia trigger/marker is detected from a patient, and based on the trigger/marker, the system estimates a probability of a cardiac arrhythmia occurring during a predetermined future time interval. The system provides a list of triggers/markers, for which detection values are recurrently obtained at various predetermined time intervals. Based on detection values and conditional probabilities associated with the triggers/markers, a probability estimate of a future arrhythmia is computed. An arrhythmia prevention therapy is selected and activated based on the probability estimate of the future arrhythmia.
摘要翻译： 心律管理系统预测何时发生心律失常，并且在一个实施例中调用治疗以预防或减少心律失常的后果。 从患者检测到心律失常触发/标记，并且基于触发/标记，系统估计在预定的未来时间间隔期间发生心律失常的概率。 该系统提供了一个触发/标记列表，为各种预定时间间隔循环获得检测值。 基于与触发/标记相关联的检测值和条件概率，计算未来心律失常的概率估计。 基于对未来心律失常的概率估计，选择并激活心律失常预防疗法。
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68.发明授权Method and apparatus for treating ventricular fibrillation using electrogram features 失效使用电描记图特征治疗心室颤动的方法和装置公开(公告)号：US06251125B1
公开(公告)日：2001-06-26
申请号：US09053115
申请日：1998-04-01
申请人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
发明人： Bruce H. KenKnight , William Hsu , Yayun Lin , Janice Jones
IPC分类号： A61N139
CPC分类号： A61N1/3962
摘要： A method and system for ventricular defibrillation by coordinating the delivery of defibrillation shocks with sensed ventricular fibrillation complexes in a way which improves the probability of success of the defibrillation shock. Ventricular electrical activity is monitored in two ventricular locations during ventricular fibrillation to detect coarse ventricular fibrillation complexes and contractions of the ventricular cardiac tissue. The defibrillation shock is delivered in coordination with the occurrence of coarse ventricular fibrillation complexes and the contractions of ventricular cardiac tissue, and specifically to occur on the up-slope portion thereof, for optimal probability of success.
摘要翻译： 通过以提高除颤休克成功概率的方式协调将感染的心室颤动复合物递送除颤电击的心室除颤的方法和系统。 在心室纤维性颤动期间，在两个心室位置监测心室电活动，以检测心室心脏组织的粗略心室颤动复合物和收缩。 伴随发生粗心室颤动复合物和心室心脏组织的收缩，特别是在其上坡部分发生除颤休克，以获得最佳的成功概率。
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公开(公告)号：US06168801A
公开(公告)日：2001-01-02
申请号：US09272428
申请日：1999-03-19
IPC分类号： A61F202
CPC分类号： A61K9/0024
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.
摘要翻译： 生物活性材料提供在圆柱形载体介质中，通过提供具有溶解或分散在其中的至少两种具有共同的生物活性核，但具有不同溶解度参数的化合物的载体，可以更好地控制输送速率和输送时间。 具有不同溶解度参数的相同药物的两种不同变体的组合提供了材料对化合物释放速率的控制（通过改变变体的比例），最重要的是通过使得能够延长器件的使用寿命 在更长的时间内释放有效含量的化合物。 由硅树脂构成的圆柱形载体介质还包括尾部，裙部或限速膜。
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70.发明授权Implantable conformal coil patch electrode with multiple conductive elements for cardioversion and defibrillation 失效可植入的保形线圈贴片电极，具有多个用于心脏复律和除颤的导电元件
公开(公告)号：US6152955A
公开(公告)日：2000-11-28
申请号：US240396
申请日：1999-01-29
CPC分类号： A61N1/0587
摘要： Body-implantable leads with open, unbacked (uninsulated) electrode structures having electrical discharge surfaces formed by conductive elements, such as mesh and braid, and preferably coils. The electrode structures can be classified by pattern: (1) loops, (2) linear arrays and (3) radial arrays. The electrodes are located on or near the epicardial surface of the right and left heart.
摘要翻译： 具有开放，未背衬（未绝缘）电极结构的体内可植入引线，其具有由诸如网和编织物的导电元件形成的放电表面，并且优选线圈。 电极结构可以通过图案分类：（1）环，（2）线性阵列和（3）径向阵列。 电极位于右心左心外表面上或附近。
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