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1.发明授权Method for reducing arterial restenosis in the presence of an intravascular stent 失效在血管内支架存在下减少动脉再狭窄的方法公开(公告)号：US06648881B2
公开(公告)日：2003-11-18
申请号：US09940337
申请日：2001-08-27
IPC分类号： A61B1804
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译： 第一电极位于植入的血管内支架附近的动脉内。 第二电极相对于第一电极的位置定位在单独的位置。 然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。 当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间 心动周期。
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2.发明授权公开(公告)号：US06519488B2
公开(公告)日：2003-02-11
申请号：US09940336
申请日：2001-08-27
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
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3.发明授权公开(公告)号：US06939345B2
公开(公告)日：2005-09-06
申请号：US10397623
申请日：2003-03-26
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译： 第一电极位于植入的血管内支架附近的动脉内。 第二电极相对于第一电极的位置定位在单独的位置。 然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。 当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间 心动周期。
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4.发明授权Method and system for reducing arterial restenosis in the presence of an intravascular stent 有权在血管内支架存在下减少动脉再狭窄的方法和系统公开(公告)号：US06317615B1
公开(公告)日：2001-11-13
申请号：US09294724
申请日：1999-04-19
IPC分类号： A61B504
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00285 , A61B2018/00839
摘要： A first electrode is positioned within an artery proximate an implanted intravascular stent. A second electrode is positioned at a separate location relative the position of the first electrode. Electrical energy is then delivered between the first and the second electrodes to produce an electrical field adjacent the implanted intravascular stent. When a intravascular stent is implanted in a coronary artery, the delivery of the electrical energy is coordinated to cardiac cycles detected in sensed cardiac signals, where the delivery of the electrical energy between the first electrode and the second electrode occurs during a predetermined portion of the cardiac cycle.
摘要翻译： 第一电极位于植入的血管内支架附近的动脉内。 第二电极相对于第一电极的位置定位在单独的位置。 然后在第一和第二电极之间传递电能，以产生邻近植入的血管内支架的电场。 当将血管内支架植入冠状动脉中时，电能的传递与在感测到的心脏信号中检测到的心脏周期协调，其中第一电极和第二电极之间的电能的传递发生在第一电极和第二电极的预定部分期间 心动周期。
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公开(公告)号：US06980851B2
公开(公告)日：2005-12-27
申请号：US10001223
申请日：2001-11-15
IPC分类号： A61N1/362 , A61N1/365 , A61B5/0402
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译： 一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹 患者的心力衰竭状态。 这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。
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6.发明授权公开(公告)号：US06205357B1
公开(公告)日：2001-03-20
申请号：US09206022
申请日：1998-12-04
IPC分类号： A61N139
CPC分类号： A61N1/3622
摘要： An implantable system for detecting electrical activity from a patient's heart comprises a first sensing electrode configured for positioning through the coronary sinus ostium and within a vein on the left surface of the left ventricle of the heart for sensing electrical activity from the heart, and a detector operatively associated with the first sensing electrode for determining (e.g., diagnosing or prognosing) a medical condition of the heart with the sensed electrical activity. Typically the system further comprises a second sensing electrode configured for positioning in the right ventricle of the heart, where the detector is operatively associated with both the first sensing electrode and the second sensing electrode. The second sensing electrode may be positioned in other locations as well, such as also within a vein on the left surface of the left ventricle of the heart (although spaced apart from the first sensing electrode), in the right atrium, in the superior vena cava, etc. Finally, a third sensing electrode may also be included, with the third electrode positioned in any of the foregoing locations (again, spaced apart from the first and second electrodes), with the detector operatively associated with all of the first, second, and third sensing electrodes. Determination of a medical condition may be carried out by any suitable means, such as by detecting premature beats in the heart. The method is particularly useful for identifying the chamber of premature beat origin.
摘要翻译： 用于从患者心脏检测电活动的可植入系统包括构造成用于定位穿过冠状窦口和心脏左心室左表面的静脉内的第一感测电极，用于感测来自心脏的电活动;以及检测器 可操作地与第一感测电极相关联，用于利用感测到的电活动来确定（例如，诊断或预测）心脏的医学状况。 通常，该系统还包括被配置用于定位在心脏的右心室中的第二感测电极，其中检测器与第一感测电极和第二感测电极两者可操作地相关联。 第二感测电极也可以位于其他位置，例如也在心脏左心室左侧的静脉内（尽管与第一感测电极间隔开），在右心房中，在上腔静脉 卡瓦等。最后，还可以包括第三感测电极，其中第三电极位于上述任何位置（再次与第一和第二电极间隔开），检测器与所有第一， 第二和第三感测电极。 可以通过任何合适的手段来进行医学状态的确定，例如通过检测心脏中的过早搏动。 该方法对于识别过早搏动起源的室特别有用。
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公开(公告)号：US07769437B2
公开(公告)日：2010-08-03
申请号：US11299876
申请日：2005-12-12
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61N1/36585
摘要： A method for operating a cardiac rhythm management device in which a clinical state vector is computed as a combination of a plurality of parameters related to a patient's heart failure status and compared to a previously computed clinical state vector to determine a clinical trajectory indicative of changes in the patient's heart failure status. Such detected changes in status can be used both as a clinical tool to evaluate treatment and to automatically adjust the operation of the device.
摘要翻译： 一种用于操作心律管理装置的方法，其中临床状态矢量被计算为与患者心力衰竭状态相关的多个参数的组合，并且与先前计算的临床状态向量进行比较，以确定指示变化的临床轨迹 患者的心力衰竭状态。 这种检测到的状态变化可以用作临床工具来评估治疗并自动调整装置的操作。
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公开(公告)号：US08915741B2
公开(公告)日：2014-12-23
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： G09B23/28 , A61B5/0205 , A61B5/00 , A61B5/0488 , A61B5/11 , A61B5/0476 , A61N1/362 , A61B5/08 , A61B5/0496
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译： 睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。 使用可植入装置执行检测患者状况和收集数据中的至少一个。 可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。 睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。
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9.发明授权Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权用于选择治疗慢性心脏功能障碍的颈部迷走神经电刺激治疗方案的计算机实现系统和方法公开(公告)号：US08630709B2
公开(公告)日：2014-01-14
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译： 提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。 外部编程器包括存储在存储器中的多个治疗简档。 治疗概况包括不同组的刺激参数，其协作地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。 编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。 最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。 可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极治疗性地刺激颈部迷走神经。
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10.发明授权System and method for predicting patient health within a patient management system 失效用于预测患者管理系统内的患者健康的系统和方法公开(公告)号：US08628471B2
公开(公告)日：2014-01-14
申请号：US12827985
申请日：2010-06-30
申请人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
发明人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
IPC分类号： A61B5/0452 , A61B5/026 , A61B5/0205 , A61B5/053
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0205 , A61B5/0456 , A61B5/0464 , A61B5/0809 , A61B5/11 , A61B5/14532 , A61B2562/0219
摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。
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