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公开(公告)号：US06168801A
公开(公告)日：2001-01-02
申请号：US09272428
申请日：1999-03-19
IPC分类号： A61F202
CPC分类号： A61K9/0024
摘要： Biologically active materials are provided in a cylindrical carrier medium with better control over the rate of delivery and length of time of delivery by providing a carrier having dissolved or dispersed therein at least two compounds having a common biologically active nucleus, but with different solubility parameters. The combination of the two different variants of the same drug with different solubility parameters provides the material with control over the rate of release of the compounds (by varying the proportions of the variants) and most importantly, extending the useful life of the device by enabling release of effective levels of the compounds over a longer period of time. The cylindrical carrier medium, comprised of silicone, further includes a tail, a skirt, or a rate-limiting membrane.
摘要翻译： 生物活性材料提供在圆柱形载体介质中，通过提供具有溶解或分散在其中的至少两种具有共同的生物活性核，但具有不同溶解度参数的化合物的载体，可以更好地控制输送速率和输送时间。 具有不同溶解度参数的相同药物的两种不同变体的组合提供了材料对化合物释放速率的控制（通过改变变体的比例），最重要的是通过使得能够延长器件的使用寿命 在更长的时间内释放有效含量的化合物。 由硅树脂构成的圆柱形载体介质还包括尾部，裙部或限速膜。
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公开(公告)号：US08915741B2
公开(公告)日：2014-12-23
申请号：US13215592
申请日：2011-08-23
申请人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
发明人： John D. Hatlestad , Quan Ni , Jeffrey E. Stahmann , Jesse Hartley , Qingsheng Zhu , Bruce H. KenKnight , Douglas R. Daum , Kent Lee
IPC分类号： G09B23/28 , A61B5/0205 , A61B5/00 , A61B5/0488 , A61B5/11 , A61B5/0476 , A61N1/362 , A61B5/08 , A61B5/0496
CPC分类号： A61B5/4815 , A61B5/0031 , A61B5/0205 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/0809 , A61B5/11 , A61B5/4528 , A61B5/4818 , A61N1/3621 , G06F19/00
摘要： A sleep quality assessment approach involves collecting data based on detected physiological or non-physiological patient conditions. At least one of detecting patient conditions and collecting data is performed using an implantable device. Sleep quality may be evaluated using the collected data by an implantable or patient-external sleep quality processor. One approach to sleep quality evaluation involves computing one or more summary metrics based on occurrences of movement disorders or breathing disorders during sleep.
摘要翻译： 睡眠质量评估方法包括基于检测到的生理或非生理性患者状况收集数据。 使用可植入装置执行检测患者状况和收集数据中的至少一个。 可以使用可植入或患者外部的睡眠质量处理器收集的数据来评估睡眠质量。 睡眠质量评估的一种方法包括基于睡眠期间的运动障碍或呼吸障碍的发生来计算一个或多个总结度量。
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3.发明授权Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction 有权用于选择治疗慢性心脏功能障碍的颈部迷走神经电刺激治疗方案的计算机实现系统和方法公开(公告)号：US08630709B2
公开(公告)日：2014-01-14
申请号：US13314138
申请日：2011-12-07
申请人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
发明人： Imad Libbus , Badri Amurthur , Bruce H. KenKnight
IPC分类号： A61N1/05
CPC分类号： A61N1/36053 , A61N1/36114 , A61N1/37235 , A61N1/37247
摘要： A computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction is provided. An external programmer includes a plurality of therapy profiles stored in memory. The therapy profiles include different sets of stimulation parameters that cooperatively define alternating cycles of stimuli application and stimuli inhibition for a neurostimulator that are tuned to both efferently activate the heart's intrinsic nervous system and afferently activate the patient's central reflexes. A programming wand is configured to provide the set of stimulation parameters chosen by the user to the neurostimulator through wireless telemetry. Finally, an implantable neurostimulator device includes a stimulation therapy lead terminated by helical electrodes and electrically coupled to the neurostimulator. The implantable neurostimulator is configured to therapeutically stimulate the cervical vagus nerve through the helical electrodes by triggering bi-directional action potentials as specified by the selected set of stimulation parameters.
摘要翻译： 提供了一种用于选择用于治疗慢性心脏功能障碍的颈部迷走神经的电刺激的治疗方案的计算机实现的系统和方法。 外部编程器包括存储在存储器中的多个治疗简档。 治疗概况包括不同组的刺激参数，其协作地定义刺激应用的交替循环和神经刺激器的刺激抑制，所述神经刺激器被调谐以显着激活心脏的内在神经系统并传播激活患者的中心反射。 编程棒被配置为通过无线遥测将用户选择的一组刺激参数提供给神经刺激器。 最后，植入式神经刺激器装置包括由螺旋电极终止并电耦合到神经刺激器的刺激治疗引线。 可植入神经刺激器被配置为通过触发由所选择的一组刺激参数指定的双向动作电位来通过螺旋电极治疗性地刺激颈部迷走神经。
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4.发明授权System and method for predicting patient health within a patient management system 失效用于预测患者管理系统内的患者健康的系统和方法公开(公告)号：US08628471B2
公开(公告)日：2014-01-14
申请号：US12827985
申请日：2010-06-30
申请人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
发明人： Scott T. Mazar , Richard Fogoros , Yatheendhar D. Manicka , Bruce H. KenKnight , Michael J. Pederson
IPC分类号： A61B5/0452 , A61B5/026 , A61B5/0205 , A61B5/053
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0205 , A61B5/0456 , A61B5/0464 , A61B5/0809 , A61B5/11 , A61B5/14532 , A61B2562/0219
摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。
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5.发明授权Method and apparatus for establishing context among events and optimizing implanted medical device performance 有权用于在事件之间建立上下文并优化植入的医疗设备性能的方法和装置公开(公告)号：US08160716B2
公开(公告)日：2012-04-17
申请号：US12891338
申请日：2010-09-27
申请人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
发明人： Bruce H. KenKnight , Eric G. Lovett , Robert J. Sweeney , Scott T. Mazar , Yatheendhar D. Manicka
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/37211 , A61N1/37235 , A61N1/37282 , G06F19/00
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.
摘要翻译： 一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。 上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。 在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。 便携式电子设备适于用作与植入的设备进行无线通信的接口。 在一个实施例中，便携式电子设备与临床程序员接口以供医生使用。
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6.发明申请SYSTEM AND METHOD FOR PREDICTING PATIENT HEALTH WITHIN A PATIENT MANAGEMENT SYSTEM 失效在患者管理系统中预测患者健康的系统和方法公开(公告)号：US20100268095A1
公开(公告)日：2010-10-21
申请号：US12827985
申请日：2010-06-30
申请人： Scott Thomas Mazar , Richard Fogoros , Yatheendhar Manicka , Bruce H. KenKnight , Michael J. Pederson
发明人： Scott Thomas Mazar , Richard Fogoros , Yatheendhar Manicka , Bruce H. KenKnight , Michael J. Pederson
IPC分类号： A61B5/0205 , A61B5/08
CPC分类号： A61B5/14546 , A61B5/0031 , A61B5/0205 , A61B5/0456 , A61B5/0464 , A61B5/0809 , A61B5/11 , A61B5/14532 , A61B2562/0219
摘要： Systems and Methods for predicting patient health and patient relative well-being within a patient management system are disclosed. A preferred embodiment utilizes an implantable medical device comprising an analysis component and a sensing component further comprising a three-dimensional accelerometer, a transthoracic impedance sensor, a cardio-activity sensor, an oxygen saturation sensor and a blood glucose sensor. Some embodiments of a system disclosed herein also can be configured as an Advanced Patient Management System that helps better monitor, predict and manage chronic diseases.
摘要翻译： 公开了用于预测患者健康状况和患者管理系统内患者相对健康的系统和方法。 优选实施例利用包括分析部件和感测部件的可植入医疗装置，其进一步包括三维加速度计，经胸阻抗传感器，心脏活动传感器，氧饱和度传感器和血糖传感器。 本文公开的系统的一些实施例还可以被配置为有助于更好地监测，预测和管理慢性疾病的高级患者管理系统。
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7.发明授权Method and apparatus for establishing context among events and optimizing implanted medical device performance 有权用于在事件之间建立上下文并优化植入的医疗设备性能的方法和装置公开(公告)号：US07805199B2
公开(公告)日：2010-09-28
申请号：US11381051
申请日：2006-05-01
IPC分类号： A61N1/08
CPC分类号： A61N1/36514 , A61N1/3627 , A61N1/37211 , A61N1/37235 , A61N1/37282 , G06F19/00
摘要： An apparatus and method for adjusting the performance of an implanted device based on data including contextual information. Contextual information, including operational and performance data concerning the implanted device as well as the patient with the implanted device, is stored by a portable electronic device. In one embodiment, the portable electronic device is adapted for battery operation and includes a personal digital assistant (PDA). The portable electronic device is adapted for use as an interface to conduct wireless communications with the implanted device. In one embodiment, the portable electronic device interfaces with a clinical programmer for use by a physician.
摘要翻译： 一种用于基于包括上下文信息的数据来调整植入装置的性能的装置和方法。 上下文信息，包括关于植入装置的操作和性能数据以及具有植入装置的患者，由便携式电子装置存储。 在一个实施例中，便携式电子设备适用于电池操作并且包括个人数字助理（PDA）。 便携式电子设备适于用作与植入的设备进行无线通信的接口。 在一个实施例中，便携式电子设备与临床程序员接口以供医生使用。
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8.发明授权Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device 有权通过可植入心脏装置的联合重塑控制治疗和抗重塑治疗公开(公告)号：US07805193B2
公开(公告)日：2010-09-28
申请号：US11777394
申请日：2007-07-13
IPC分类号： A61N1/368
CPC分类号： A61N1/362 , A61N1/36114 , A61N1/3627
摘要： A method and device for delivering ventricular resynchronization pacing therapy in conjunction with electrical stimulation of nerves which alter the activity of the autonomic nervous system is disclosed. Such therapies may be delivered by an implantable device and are useful in preventing the deleterious ventricular remodeling which occurs as a result of a heart attack or heart failure. The device may perform an assessment of cardiac function in order to individually modulate the delivery of the two types of therapy.
摘要翻译： 公开了一种用于将脑室再同步起搏治疗与神经改变自主神经系统的活动的电刺激结合的方法和装置。 这样的治疗可以由可植入装置递送，并且可用于防止由于心脏病发作或心力衰竭而发生的有害心室重构。 该装置可以执行心脏功能的评估，以便单独地调节两种类型的治疗的递送。
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公开(公告)号：US07729762B2
公开(公告)日：2010-06-01
申请号：US11267071
申请日：2005-11-03
IPC分类号： A61N1/00
CPC分类号： A61N1/3962
摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.
摘要翻译： 公开了以自适应方式递送抗心动过速起搏的方法和装置。 具有抗心动过速起搏能力的心脏节律管理装置，例如可植入心脏起搏器，在检测到可终止的心律失常时，根据选定的起搏方案提供抗心动过速起搏治疗。 协议从可用协议库中选择。 在用于选择协议的结果表中保留了每种可用协议在转换快速性心律失常方面的成功和失败的记录。
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公开(公告)号：US07627373B2
公开(公告)日：2009-12-01
申请号：US10723258
申请日：2003-11-25
IPC分类号： A61N1/00
CPC分类号： A61N1/362
摘要： A method for cell and electrical therapy of living tissue including administration of exogenous cells into a region of injured tissue and application of electrical energy. In one application the combined cell and electrical therapy is applied in vivo to damaged heart tissue. In such applications, minimally invasive procedures are used to apply the cell therapy and the electrical therapy is provided via an implantable pulse generator. In one application an implantable pacemaker is used in the VDD mode with an atrioventricular delay kept relatively short when compared to the intrinsic atrioventricular delay.
摘要翻译： 一种用于生物组织的细胞和电疗法的方法，包括将外源细胞施用到损伤组织的区域中并施加电能。 在一个应用中，组合的细胞和电疗法在体内应用于损伤的心脏组织。 在这样的应用中，使用微创手术来应用细胞治疗，并且通过可植入脉冲发生器提供电疗法。 在一个应用中，可以使用植入式起搏器进行VDD模式，与内在房室延迟相比，房室延迟保持相对较短。
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