公开(公告)号：US06399604B1

公开(公告)日：2002-06-04

申请号：US09634093

申请日：2000-08-08

申请人： Pamela A. Albaugh ,  Robert W. DeSimone ,  Gang Liu

发明人： Pamela A. Albaugh ,  Robert W. DeSimone ,  Gang Liu

IPC分类号： A61K31535

CPC分类号： C07D471/04

摘要： The present invention encompasses structures of the Formula or the pharmaceutically acceptable non-toxic salts thereof wherein: X is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; and Y is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

摘要翻译： 本发明包括式的药学上可接受的无毒盐的结构，其中：X是氢，卤素，（未）取代的烷基，（未）取代的烷氧基或氨基; 和Y是（未）取代的烷基，芳基或杂芳基，该化合物是GABAa脑受体的高选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 这些化合物可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和癫痫发作，以及用苯二氮卓类药物过量并提高警觉性。

公开(公告)号：US06380209B1

公开(公告)日：2002-04-30

申请号：US09583147

申请日：2000-05-30

申请人： Guolin Cai ,  Gang Liu

发明人： Guolin Cai ,  Gang Liu

IPC分类号： A61K314375

CPC分类号： C07D471/04 ,  C07D495/04

摘要： Disclosed are compounds of the formula or the pharmaceutically acceptable non-toxic salts thereof wherein: R is hydrogen, alkyl, or(un)substituted alkoxy or amino; and W is (un)substituted alkyl, aryl, or heteroaryl, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. The compounds of the invention are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中：R是氢，烷基或（未）取代的烷氧基或氨基; 和W是（未取代的）取代的烷基，芳基或杂芳基，该化合物是GABAa脑受体的高度选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 本发明的化合物可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和发作障碍，以及用苯二氮卓类药物过量并提高警觉性。

公开(公告)号：US06228868B1

公开(公告)日：2001-05-08

申请号：US09360463

申请日：1999-07-23

申请人： Stephen L. Gwaltney, II ,  Hwan-Soo Jae ,  Douglas M. Kalvin ,  Gang Liu ,  Hing L. Sham ,  Qun Li ,  Akiyo K. Claiborne ,  Le Wang ,  Kenneth J. Barr ,  Keith W. Woods

发明人： Stephen L. Gwaltney, II ,  Hwan-Soo Jae ,  Douglas M. Kalvin ,  Gang Liu ,  Hing L. Sham ,  Qun Li ,  Akiyo K. Claiborne ,  Le Wang ,  Kenneth J. Barr ,  Keith W. Woods

IPC分类号： A61K31421

CPC分类号： C07D413/04 ,  C07D263/14

摘要： Compounds having Formula I are useful for treating cancer. Also disclosed are pharmaceutical compositions comprising compounds of Formula I, and methods of treating cancer in a mammal.

摘要翻译： 具有式Iare的化合物可用于治疗癌症。 还公开了包含式I化合物的药物组合物和治疗哺乳动物癌症的方法。

公开(公告)号：US06211365B1

公开(公告)日：2001-04-03

申请号：US09387313

申请日：1999-08-31

申请人： Pamela Albaugh ,  Gang Liu ,  Kenneth Shaw ,  Alan Hutchison

发明人： Pamela Albaugh ,  Gang Liu ,  Kenneth Shaw ,  Alan Hutchison

IPC分类号： C07D41312

CPC分类号： C07D401/12 ,  C07D209/42 ,  C07D209/52 ,  C07D405/12 ,  C07D413/12

摘要： Disclosed are compounds of the formula: or the pharmaceutically acceptable non-toxic salts thereof wherein: G, X, T, n, and R3-R6 are as defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

摘要翻译： 公开了下式的化合物或其药学上可接受的无毒盐，其中：G，X，T，n和R3-R6如本文所定义，这些化合物是GABAa脑受体的高选择性激动剂，拮抗剂或反向激动剂 或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 这些化合物可用于诊断和治疗焦虑，睡眠和癫痫发作，用苯二氮卓类药物过量并用于记忆增强。

公开(公告)号：US6143760A

公开(公告)日：2000-11-07

申请号：US139456

申请日：1998-08-25

申请人： Pamela A. Albaugh ,  Robert W. DeSimone ,  Gang Liu

发明人： Pamela A. Albaugh ,  Robert W. DeSimone ,  Gang Liu

IPC分类号： C07D471/04 ,  A61K31/44 ,  C07D471/02

CPC分类号： C07D471/04

摘要： The present invention encompasses structures of the Formula ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: x is hydrogen, halogen, (un)substituted alkyl, (un)substituted alkoxy or amino; andY is (un)substituted alkyl, aryl, or heteroaryl,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, Down Syndrome, sleep, cognitive and seizure disorders, and overdose with benzodiazepine drugs and for enhancement of alertness.

摘要翻译： 本发明包括式或其药学上可接受的无毒盐的结构，其中：x是氢，卤素，（未）取代的烷基，（未）取代的烷氧基或氨基; 并且Y是（未）取代的烷基，芳基或杂芳基，该化合物是GABAa脑受体的高度选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 这些化合物可用于诊断和治疗焦虑症，唐氏综合征，睡眠，认知和癫痫发作，以及用苯二氮卓类药物过量并提高警觉性。

公开(公告)号：US6096887A

公开(公告)日：2000-08-01

申请号：US31315

申请日：1998-02-25

申请人： Pamela Albaugh ,  Gang Liu ,  Alan Hutchison

发明人： Pamela Albaugh ,  Gang Liu ,  Alan Hutchison

IPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04 ,  C07D409/06 ,  C07D209/02 ,  C07D401/06 ,  C07D403/06

CPC分类号： C07D401/12 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12 ,  C07D471/04

摘要： The present invention encompasses structures of the formula I: ##STR1## or the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## W represents substituted or unsubstituted heteroaryl; X is hydrogen, hydroxy or lower alkyl;T is hydrogen, halogen, hydroxy, nitro, amino or alkyl;R.sub.3 is hydrogen or an organic group;R.sub.4 is hydrogen or substituted or unsubstituted organic substituent;R.sub.5 and R.sub.6 represent organic, and inorganic substituents; and n is 1,2,3, or 4,which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors. These compounds are useful in the diagnosis and treatment of anxiety, sleep and seizure disorders, overdose with benzodiazepine drugs and for enhancement of memory.

摘要翻译： 本发明包括式I的结构：或其药学上可接受的无毒盐，其中：W表示取代或未取代的杂芳基; X是氢，羟基或低级烷基; T是氢，卤素，羟基，硝基，氨基或烷基; R3是氢或有机基团; R4是氢或取代或未取代的有机取代基; R5和R6代表有机和无机取代基; 并且n是1,2,3或4，这些化合物是用于GABAa脑受体的高选择性激动剂，拮抗剂或反向激动剂或GABAa脑受体的激动剂，拮抗剂或反向激动剂的前药。 这些化合物可用于诊断和治疗焦虑，睡眠和癫痫发作，用苯二氮卓类药物过量并用于记忆增强。

公开(公告)号：US6046801A

公开(公告)日：2000-04-04

申请号：US997440

申请日：1997-12-23

申请人： Gang Liu ,  Mark H. Schwartz

发明人： Gang Liu ,  Mark H. Schwartz

IPC分类号： G01N21/95 ,  G01N21/16

CPC分类号： G01N21/9506

摘要： A laser-based optical inspection system is provided for detecting and measuring surface imperfections and warpage conditions in an optical information storage disk either during its manufacture or afterwards. The optical inspection system includes a light source, a rotatable mirror for directing a source beam from the light source along a radial line on the surface of the disk, a convex lens positioned between the mirror and the disk for focusing the source beam at the surface of said disk, and a photodetector for registering a beam being reflected from the surface of said disk, such that the reflected beam is indicative of surface imperfections in said disk. In addition, an electronic processor and controller are connected to the photodetector for processing its registered beam signals and for determining if the disk surface imperfections exceeds specified tolerances. Furthermore, the processor may be used to control other system components, including the light source, the actuator device for rotating the mirror, and the drive motor for rotating the disk during the inspection process. These results about the warpage and any surface imperfection of the disk can be displayed on the monitor of the computer to inform the machine operator as well as sent to other related manufacturing machines for further usage.

摘要翻译： 提供了一种基于激光的光学检查系统，用于在光学信息存储盘的制造期间或之后检测和测量光学信息存储盘中的表面缺陷和翘曲状况。 光学检查系统包括光源，用于沿光盘的径向线引导源光束的可旋转镜，位于反射镜和盘之间的凸透镜，用于将源光束聚焦在表面 以及用于对准从所述盘的表面反射的光束的光电检测器，使得所述反射光束指示所述盘中的表面缺陷。 此外，电子处理器和控制器连接到光电检测器，用于处理其注册的波束信号并且用于确定盘表面缺陷是否超过指定的公差。 此外，处理器可以用于控制其他系统组件，包括光源，用于旋转镜的致动器装置，以及用于在检查过程中旋转盘的驱动马达。 关于翘曲和盘的任何表面缺陷的这些结果可以显示在计算机的监视器上，以通知机器操作者以及发送到其他相关制造机器以供进一步使用。

公开(公告)号：US6015064A

公开(公告)日：2000-01-18

申请号：US996860

申请日：1997-12-23

申请人： Gang Liu

发明人： Gang Liu

IPC分类号： A45C3/00 ,  A45C13/02 ,  B25H3/00 ,  B25H3/02 ,  B65D1/24 ,  B65D85/42

CPC分类号： B25H3/023 ,  A45C13/02 ,  B25H3/00 ,  A45C3/00

摘要： A portable closable container has individually closable cells under a main lid. The container has a base with which the main lid defines an internal space. The internal space is partially filled by a plurality of side-by-side, top-to-bottom individual cells. Each of the cells is fitted with a removable cover which is hingedly mounted to the cell. The removable cover of the cell includes a tab for manipulation by the user's finger. A space is provided for a label on the cover of the cell. The components of the container are preferably composed of a polymerized material, such as polypropylene. There are two slots on the main lid which match the two feet on the base. These slots and the feet allow one container of the same kind to be stacked on the top of another without one shifting with respect to the other away from each other.

摘要翻译： 便携式可关闭容器在主盖下方具有单独封闭的电池。 容器具有基座，主盖子通过该基座限定内部空间。 内部空间由多个并排的顶部到底部的单个电池部分地填充。 每个电池都装配有可拆卸的盖子，该盖子铰接地安装到电池单元上。 电池的可拆卸盖包括用于由用户的手指操纵的突舌。 为电池盖上的标签提供了一个空间。 容器的组分优选由聚合材料如聚丙烯组成。 主盖上有两个槽，与底座上的两只脚匹配。 这些槽和脚允许一个相同类型的容器堆叠在另一个的顶部上，而不会相对于另一个远离彼此移动。

公开(公告)号：US09614678B2

公开(公告)日：2017-04-04

申请号：US13157714

申请日：2011-06-10

申请人： Michael Brundridge ,  Sruthi Mothukupally ,  Darrell Rosser ,  Gang Liu ,  Jason C. Dale ,  Marshal F. Savage

发明人： Michael Brundridge ,  Sruthi Mothukupally ,  Darrell Rosser ,  Gang Liu ,  Jason C. Dale ,  Marshal F. Savage

IPC分类号： G06F15/16 ,  H04L9/32 ,  G06F21/10

CPC分类号： G06F21/105 ,  G06F21/10 ,  H04L9/3247 ,  H04L2209/68 ,  H04L2463/103

摘要： An information handling system includes a device, a controller, and a license manager subsystem. The controller is configured to determine whether the device has a license assigned and to extract a unique identification for the device in response to a request for information about the device. The license manager subsystem is configured to send the request for information about the device to the controller, to send the unique identification for the device to a license server as a request for the license for the device, to receive the license from the license server, and to assign the license to the device when the license is received.

公开(公告)号：US09434719B2

公开(公告)日：2016-09-06

申请号：US14408418

申请日：2014-03-12

申请人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

发明人： Thomas Raymond Caferro ,  Zhuoliang Chen ,  Young Shin Cho ,  Abran Q. Costales ,  Julian Roy Levell ,  Gang Liu ,  James R. Manning ,  Martin Sendzik ,  Cynthia Shafer ,  Michael David Shultz ,  James Sutton ,  Yaping Wang ,  Qian Zhao

IPC分类号： C07D413/04 ,  A61K31/506 ,  C07D413/14 ,  C07D417/14 ,  A61K31/5377

CPC分类号： C07D413/14 ,  A61K31/506 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/04 ,  C07D417/14

摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.