公开(公告)号：US07359048B2

公开(公告)日：2008-04-15

申请号：US11413910

申请日：2006-04-28

Applicant: Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

Inventor： Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.

Abstract translation: 拉曼系统包括辐射源，辐射检测器和拉曼器件或信号增强结构。 拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。 空腔包括第一反射构件，第二反射构件和设置在反射构件之间的电光材料。 电光材料表现出响应于所施加的电场而变化的折射率。 拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层，从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件 与拉曼信号增强材料层相对。 支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。

公开(公告)号：US07342656B2

公开(公告)日：2008-03-11

申请号：US11252134

申请日：2005-10-17

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.

Abstract translation: NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构，用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源，以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构，在靠近NERS-活性结构的位置提供分析物，用辐射照射NERS-活性结构和分析物，改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。

公开(公告)号：US07339666B2

公开(公告)日：2008-03-04

申请号：US10942079

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface enhanced Raman spectroscopy (SERS). SERS systems employing the structures for amplifying light of the present invention and methods of performing SERS are also disclosed.

Abstract translation: 用于放大光的结构包括其中可以定位分析物的谐振腔。 用于放大光的结构可以用于放大表面增强拉曼光谱（SERS）中使用的入射光。 还公开了采用本发明的光放大结构的SERS系统和执行SERS的方法。

公开(公告)号：US07245370B2

公开(公告)日：2007-07-17

申请号：US11030733

申请日：2005-01-06

Applicant: Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A SERS-active structure is disclosed that includes a substrate and at least two nanowires disposed on the substrate. Each of the at least two nanowires has a first end and a second end, the first end being attached to the substrate and the second end having a SERS-active tip. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少两个纳米线。 所述至少两个纳米线中的每一个具有第一端和第二端，所述第一端附接到所述基底，所述第二端具有SERS活性末端。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US20060275779A1

公开(公告)日：2006-12-07

申请号：US11144588

申请日：2005-06-03

Applicant: Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

Inventor： Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y15/00

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous material is configured to interact with an identifiable configuration of a molecule such that the molecule sensor develops a conductance change responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括可操作地耦合第一端子和第二端子的纳米线和设置在纳米线上的含氮材料。 含氮材料被配置为与分子的可识别构型相互作用，使得分子传感器响应于相互作用产生电导变化。 分子引导件被配置用于引导分子传感器附近的分子的至少一部分以实现相互作用。

公开(公告)号：US20060243897A1

公开(公告)日：2006-11-02

申请号：US11116657

申请日：2005-04-27

Applicant: Shih-Yuan Wang ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  Zhiyong Li

IPC: H05H3/04

CPC classification number: G21K1/006

Abstract: For manipulation of a specimen, the specimen and a focusing location of a composite material lens are brought into spatial coincidence. The composite material lens has at least one of a negative effective permittivity and a negative effective permeability at a frequency of an applied light beam. The composite material lens focuses the light beam toward the focusing location and forms an optical trap for the specimen.

Abstract translation: 对于样品的操作，复合材料透镜的样品和聚焦位置变得空间重合。 复合材料透镜在所施加的光束的频率处具有负的有效介电常数和负的有效磁导率中的至少一个。 复合材料透镜将光束聚焦到聚焦位置并形成样品的光阱。

公开(公告)号：US07102747B2

公开(公告)日：2006-09-05

申请号：US10964523

申请日：2004-10-13

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: Devices, systems, and methods using Surface Enhanced Raman Spectroscopy (SERS) are disclosed. A device for generating Raman scattered radiation comprises a laser source and a SERS-active structure. The laser source may be configured for emanating radiation from an emanating surface or by forming a depression in the laser source, which creates a region of increased evanescent field from the laser source. SERS systems and methods include a device for generating Raman scattered radiation with a detector configured to receive the Raman scattered radiation.

Abstract translation: 公开了使用表面增强拉曼光谱（SERS）的器件，系统和方法。 用于产生拉曼散射辐射的装置包括激光源和SERS-活性结构。 激光源可以被配置用于从发射表面发射辐射，或者通过在激光源中形成凹陷，其产生从激光源增加的渐逝场的区域。 SERS系统和方法包括用配置成接收拉曼散射辐射的检测器产生拉曼散射辐射的装置。

公开(公告)号：US20060055921A1

公开(公告)日：2006-03-16

申请号：US10942079

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Islam

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface enhanced Raman spectroscopy (SERS). SERS systems employing the structures for amplifying light of the present invention and methods of performing SERS are also disclosed.

Abstract translation: 用于放大光的结构包括其中可以定位分析物的谐振腔。 用于放大光的结构可以用于放大表面增强拉曼光谱（SERS）中使用的入射光。 还公开了采用本发明的光放大结构的SERS系统和执行SERS的方法。

公开(公告)号：US20060055920A1

公开(公告)日：2006-03-16

申请号：US10941714

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

Inventor： Shih-Yuan Wang ,  M. Islam ,  Zhiyong Li

IPC: G01J3/44

CPC classification number: G01N21/658 ,  G01J3/26

Abstract: Wavelength-tunable radiation amplifying structures for Raman spectroscopy are disclosed that include resonant cavities having Raman signal-enhancing structures disposed therein. Systems that include the amplifying structures and methods of performing spectroscopic analysis using the structures and systems are also disclosed.

Abstract translation: 公开了用于拉曼光谱的波长可调辐射放大结构，其包括其中布置有拉曼信号增强结构的谐振腔。 还公开了包括放大结构的系统和使用该结构和系统进行光谱分析的方法。

公开(公告)号：US09212997B2

公开(公告)日：2015-12-15

申请号：US14405334

申请日：2012-07-29

Applicant: Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

Inventor： Gary Gibson ,  Zhiyong Li ,  Alexandre M. Bratkovski ,  Shih-Yuan Wang ,  Huei Pei Kuo ,  Steven Barcelo ,  Zhang-Lin Zhou

IPC: G01J3/44 ,  G01N21/65 ,  B82Y15/00

CPC classification number: G01N21/658 ,  B82Y15/00 ,  G01J3/4412 ,  G01N2021/651 ,  G01N2201/06113 ,  Y10S977/902

Abstract: A scattering spectroscopy nanosensor includes a nanoscale-patterned sensing substrate to produce an optical scattering response signal indicative of a presence of an analyte when interrogated by an optical stimulus. The scattering spectroscopy nanosensor further includes a protective covering to cover and protect the nanoscale-patterned sensing substrate. The protective covering is to be selectably removed by exposure to an optical beam incident on the protective covering. The protective covering is to prevent the analyte from interacting with the nanoscale-patterned sensing substrate prior to being removed.

Abstract translation: 散射光谱纳米传感器包括纳米级图案化的感测衬底，以产生指示当通过光学刺激询问的分析物存在时的光学散射响应信号。 散射光谱纳米传感器还包括覆盖并保护纳米级图案化感测基板的保护覆盖层。 通过暴露在入射到保护罩上的光束可选地去除保护罩。 保护性覆盖物是在去除之前防止分析物与纳米级图案化的感测基板相互作用。