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公开(公告)号：US20230069622A1
公开(公告)日：2023-03-02
申请号：US17705798
申请日：2022-03-28
IPC分类号： A61K31/4439 , A61K31/337 , A61K31/7068 , A61P35/00 , A61K31/404 , A61K31/7048 , A61K45/06 , C12Q1/48 , G01N33/574
摘要： Disclosed is a method for enhancing tumor response to chemotherapy, the method comprising administering a short-acting anti-angiogenic agent (AAA) capable of activating ASMase to a subject afflicted with a solid tumor, and thereby creating a time interval of increased susceptibility of said tumor to one or more chemotherapeutic agents, followed by administration of at least one chemotherapeutic agent within the interval. The interval can be defined in terms of a short-duration activation of ASMase signaling by the AAA. Disclosed are also methods for predicting the tumor response in a patient afflicted with a solid tumor to a chemotherapeutic agent, using as an indicator of the response ASMase level or activity (or ceramide level) in the patient following the administration of the chemotherapeutic agent to the patient, or dynamic IVIM based DW-MRI to measure perfusion alterations following administration of the chemotherapeutic agent.
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公开(公告)号：US20230057304A1
公开(公告)日：2023-02-23
申请号：US17681342
申请日：2022-02-25
发明人： Liang DENG , Stewart SHUMAN , Jedd WOLCHOK , Taha MERGHOUB , Weiyi WANG , Peihong DAI , Ning YANG
IPC分类号： A61K39/395 , A61K39/00 , C12N15/86 , C07K16/28 , C07K14/52 , A61K35/768 , A61P35/00 , A61K9/00
摘要： The present disclosure relates generally to the fields of oncology, virology and immunotherapy. It concerns poxviruses, specifically the highly attenuated modified vaccinia virus Ankara (MVA), and a recombinant modified vaccinia Ankara virus with deletion of vaccinia virulence factor E3 (MVAΔE3L), each further modified to express human Fms-like tyrosine kinase 3 ligand (Flt3L) or GM-CSF. The disclosure relates to use of the foregoing recombinant viruses as cancer immunotherapeutic agents. The foregoing recombinant poxviruses can also be used in combination with immune checkpoint blockade therapy.
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公开(公告)号：US11568618B2
公开(公告)日：2023-01-31
申请号：US16634465
申请日：2018-07-27
IPC分类号： G06T19/20 , G16H30/20 , A61B5/00 , A61B5/055 , A61B5/107 , A61B6/03 , A61B6/04 , A61B8/00 , A61N5/10
摘要： Described herein are systems and methods of processing immobilization molds for application of treatment, A computing system may generate a three-dimensional mold model of immobilization mold within with a subject is to be positioned for application of a treatment. The computing system may subtract a three-dimensional scan of at least a portion of the subject from the three-dimensional mold model to define an opening therein. The computing system may remove, from the three-dimensional mold model, a first portion to define an imprint in the opening from a first axis along which the subject is to enter. The computing system may remove, from a second portion of the three-dimensional mold model remaining with the removal of the first portion, inward protrusions into the imprint of relative to the second axis intersecting the first axis.
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公开(公告)号：US11555072B2
公开(公告)日：2023-01-17
申请号：US16649617
申请日：2018-09-21
发明人： Zhihao Wu , Hong Xu , Nai-Kong Cheung
摘要： The present disclosure relates generally to immunoglobulin-related compositions such as antibodies or antigen binding fragments thereof that can bind to and neutralize the activity of A33 protein. The antibodies of the present technology are useful in methods for detecting and treating an A33-positive cancer in a subject in need thereof.
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公开(公告)号：US11548924B2
公开(公告)日：2023-01-10
申请号：US16270444
申请日：2019-02-07
发明人： David Scheinberg , Javier Pinilla-Ibarz , Rena May
摘要： This invention provides WT1 peptides and methods of treating, reducing the incidence of, and inducing immune responses against a WT1-expressing cancer, comprising same.
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66.发明申请公开(公告)号：US20220411880A1
公开(公告)日：2022-12-29
申请号：US17778729
申请日：2020-11-20
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE) , UNIVERSITE COTE D'AZUR , MEMORIAL SLOAN KETTERING CANCER CENTER , THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
IPC分类号： C12Q1/6886 , A61K31/724 , C07K16/28 , A61K38/17
摘要： In the present invention, inventors have used high throughput sequencing to identify novel mutations in ABCA1 in CM ML patient samples. Further studies in a mouse model of myelomonocytic leukemia driven by hematopoietic Tet2 deficiency have shown that these somatic mutations abrogate the tumor suppressor function of WT ABCA1, resulting in the failure to suppress canonical IL3-receptor beta signaling-driven myelopoiesis. The loss of the myelo-suppressive function of ABCA1 mutants can be overcome by raising HDL levels through overexpression of the human apolipoprotein A-1 (apoA-1) transgene. Inventors have also shown that both IL-3Rbeta blocking antibody and cyclodextrin prevented the proliferation of ABCA1 mutant-transduced Tet2 deficient BM cells similar to the effect of ABCA1-WT overexpression. Accordingly, the invention relates to a method for predicting the survival time of a subject NI suffering from CM ML comprising the step identifying at least one ABCA1 and to a method for treating said subject with HDL/ABCA recombinant (ApoA-1); cylodextrin and/or anti-IL-3Rbeta antibody.
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公开(公告)号：US20220401490A1
公开(公告)日：2022-12-22
申请号：US17841089
申请日：2022-06-15
申请人： MEMORIAL SLOAN-KETTERING CANCER CENTER , MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES , SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
发明人： Juliet N. BARKER
摘要： The present disclosure provides methods for treating hematologic malignancies in a recipient subject in need thereof comprising administering to the recipient subject an effective amount of donor myeloid progenitor cells, and an effective amount of donor umbilical cord blood (UCB) cells, wherein the UCB cells and the myeloid progenitor cells are HLA matched. In some embodiments, the donor for the myeloid progenitor cells is not related to the recipient subject and/or the donor for the UCB cells. Also disclosed herein are methods for promoting early myeloid recovery in a recipient subject following UCB transplantation.
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公开(公告)号：US11523873B2
公开(公告)日：2022-12-13
申请号：US15570589
申请日：2016-05-02
发明人： Kamran Nazim , Maribel Vazquez , Joanne Lee , Estefany Condo , Luis Cardoso , Stephen Solomon , Govindarajan Srimathveeravalli
摘要： Exemplary embodiments of the present disclosure can include for example, an apparatus, which can include a manipulating arrangement configured to cause a medical device to move, where a portion of the manipulating arrangement can be partly composed of a non-magnetic material, and a computer arrangement in a communication with the manipulating arrangement, and configured to remotely operate the manipulating arrangement. The computer arrangement can include a computer. The communication can be a wired or wireless communication. The medical device can include (i) a catheter, (ii) an endoscope, or (iii) a needle. The manipulating arrangement can include a catheter as the medical device that can be attached to a manipulator.
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公开(公告)号：US20220389102A1
公开(公告)日：2022-12-08
申请号：US17770259
申请日：2020-10-30
申请人： Memorial Sloan Kettering Cancer Center , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
发明人： Timothy A. Chan , Diego Chowell Puente , Chirag Krishna , Tobias Leander Lenz , Federica Pierini
摘要： Molecular determinants of cancer response to immunotherapy are described.
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公开(公告)号：US11518996B2
公开(公告)日：2022-12-06
申请号：US16988395
申请日：2020-08-07
IPC分类号： C12N15/113 , A61P35/00 , C07K14/00 , C12Q1/6886 , A61K38/00 , G01N33/574
摘要： The present invention provides compositions and methods for treating cancer with peptide nucleic acid agents. In some embodiments, the present invention provides methods and compositions relating to peptide nucleic acid agents that target oncogenes. For example, the present invention provides compositions, including pharmaceutical compositions, comprising agents specific for BRAF V600E inhibition, or fragments or characteristic portions thereof. The present invention further provides various therapeutic and/or diagnostic methods of using BRAF V600E specific peptide nucleic acid agents and/or compositions.
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