公开(公告)号：US20050213037A1

公开(公告)日：2005-09-29

申请号：US10810428

申请日：2004-03-29

申请人： Erkin Abdullayev ,  G. Bryan

发明人： Erkin Abdullayev ,  G. Bryan

IPC分类号： A61B3/00 ,  A61B3/10 ,  A61B3/14 ,  A61F2/14 ,  G01N21/95

CPC分类号： A61F2/142 ,  A61B3/107 ,  A61F2/141 ,  G01N21/95

摘要： This invention comprises an improvement on the examination and evaluation of donor corneas. The improved apparatus includes the incorporation of a diffused light source, or sources, which are placed posteriorly to a donor cornea, with a viewing means placed anteriorly to said cornea. The apparatus involves the addition of the diffused light sources to existing apparatus, as well as the possible incorporation of a digital video camera or other electronic viewing means, which was not usable under the prior art. The method of placement of the diffused light source or sources is also novel, as compared with the prior art. Using this apparatus and method, the diffused light passes through the cornea, and is received by the viewing means. The viewing means is able to capture and image of the cornea, where the diffused light denotes any imperfections to the cornea. Use of the diffused light allows a complete view of the entire cornea at one time. The view of the cornea may be captured using a digital video camera or other means, with the image capable of being transmitted to another viewer, or where the entire examination can be done using a high resolution monitor.

摘要翻译： 本发明包括对供体角膜的检查和评估的改进。 改进的装置包括将放置在供体角膜后方的扩散光源（或源）与放置在所述角膜前方的观察装置并入。 该装置涉及将扩散光源添加到现有装置中，以及可能并入数字摄像机或其他电子观察装置，这在现有技术中是不可用的。 与现有技术相比，扩散光源或源的放置方法也是新颖的。 使用该装置和方法，扩散光通过角膜，并被观察装置接收。 观察装置能够捕获和成像角膜，其中漫射的光表示角膜的任何缺陷。 使用漫射光允许一次完整观察整个角膜。 可以使用数字摄像机或其他手段捕获角膜的视图，其中图像能够被传输到另一观察者，或者可以使用高分辨率监视器进行整个检查。

公开(公告)号：US20030220653A1

公开(公告)日：2003-11-27

申请号：US10346664

申请日：2003-01-17

发明人： Edward Perez

IPC分类号： A61F009/007

CPC分类号： A61F9/013 ,  A61B17/32 ,  A61B2017/320052 ,  A61F2/142 ,  A61F2/147 ,  A61F9/0133

摘要： These methods, devices, and structures are useful in the field of ophthalmology; the devices and methods relate variously to separating or lifting corneal epithelium from the eye preferably in a substantially continuous layer, placing a lens or other suitable ocular or medical device beneath the epithelial membrane, and to the resulting structures formed by those procedures. The de-epilthelialization devices generally utilize a non-cutting separator or dissector that is configured to separate the epithelium at a naturally occurring cleavage surface in the eye between the epithelium and the corneal stroma (Bowman's membrane), specifically separating in the region of the lamina lucida. The separator or dissector may have a structure that rolls or vibrates (or both) at that cleavage surface or interface during the dissection step. The separated epithelium may be lifted or peeled from the surface of the eye to form an epithelial flap or a pocket. The epithelium may then be replaced on the cornea after a refractive procedure or after placement of an ocular lens (or other subepithelial device) on the eye. The subepithelial device may comprise a wide variety of synthetic, natural, or composite polymeric materials. The step of replacing epithelial tissue upon the subepithelial device or upon the anterior corneal surface promotes epithelial healing.

公开(公告)号：US06652684B1

公开(公告)日：2003-11-25

申请号：US09991824

申请日：2001-11-05

申请人： Ira G. Wong

发明人： Ira G. Wong

IPC分类号： B32B3100

CPC分类号： A61B17/00491 ,  A61B90/00 ,  A61B2017/00969 ,  A61F2/142 ,  G01N1/36 ,  G01N2001/2873

摘要： The glue-on tissue mount is a device to hold small and/or irregular-shaped biologic tissue so tissue can be manipulated, cut, trimmed, split or divide for transplant and reconstructive surgery. Biologic tissue is quickly mounted onto an acrylic mount with fast-bonding cyanoacrylate glue. On the mount tissue can be held firmly. The tissue can be cut on the mount like on a cutting board or dissected into layers. The mount can rest on flat surfaces and be used with an operating microscope or held between fingers. The glue-on tissue mount has a spherical acrylic mounting surface 12 or flat acrylic mounting surface 14 upon which the tissue is glued. The size and shape of the tissue determines if a spherical or flat mount is used. The mounting surface is attached to a cylindrical base 10 that is easily held. If the glue adhesion breaks the tissue can be anchored with sutures tied to the eyelets in the hexagonal footing of the base 10. The glue-on tissue mount can be used for cutting a variety of biologic tissue or biologic material.

摘要翻译： 胶粘组织支架是用于保持小和/或不规则形状的生物组织的装置，因此组织可以被操纵，切割，修剪，分割或分割用于移植和重建手术。 生物组织快速地安装在具有快速粘合氰基丙烯酸酯胶的丙烯酸安装。 在安装的组织上可以牢固地固定。 组织可以像切割板上一样在支架上切割或切成多层。 安装座可以放置在平坦的表面上，并可与手术显微镜一起使用或保持在手指之间。 胶粘组装支架具有球形丙烯酸安装表面12或平坦的丙烯酸安装表面14，组织被粘合在该丙烯酸安装表面14上。 组织的尺寸和形状确定是否使用球形或平坦的安装座。 安装表面附接到容易保持的圆筒形基座10上。 如果胶粘剂破裂，组织可以用连接到基底10的六边形底部的孔眼的缝合线锚定。胶粘组织支架可用于切割各种生物组织或生物材料。

公开(公告)号：US06594021B1

公开(公告)日：2003-07-15

申请号：US09552149

申请日：2000-04-18

申请人： Phillip C. Baker

发明人： Phillip C. Baker

IPC分类号： G01B902

CPC分类号： A61B3/107 ,  A61F2/142

摘要： A system for evaluating a donor cornea includes a light source for generating a beam having a predetermined characteristic and a selected configuration. The light beam characteristic can be collimated light (wavefront analysis), white light (spectral analysis), or polarized light (polarization analysis). The beam configuration can be either circular in cross-section, or it can be a slit. When circular, the light beam is transmitted through the entire cornea to identify changes in the characteristics of the light (e.g. phase shift, spectral shift, or polarization changes). These changes then determine the optical properties of the donor cornea. When configured as a slit, the light is scattered off-axis and used to measure dimensions for a profile of the donor cornea. A computer then prepares an evaluation which includes information on both the optical qualities and the dimensional profile of the donor specimen.

摘要翻译： 用于评估供体角膜的系统包括用于产生具有预定特征和选定构型的束的光源。 光束特性可以是准直光（波前分析），白光（光谱分析）或偏振光（偏振分析）。 梁的构造可以是圆形的横截面，也可以是狭缝。 当圆形时，光束被透射通过整个角膜以识别光的特性的变化（例如相移，光谱偏移或极化变化）。 这些变化然后决定供体角膜的光学性质。 当配置为狭缝时，光线偏离轴，用于测量供体角膜轮廓的尺寸。 然后，计算机准备评估，其包括关于供体标本的光学质量和尺寸轮廓的信息。

公开(公告)号：US06578964B2

公开(公告)日：2003-06-17

申请号：US10176600

申请日：2002-06-24

申请人： Leonard John Otten, III ,  Gavin R. G. Erry ,  Simon C. Woods ,  Paul Harrison

发明人： Leonard John Otten, III ,  Gavin R. G. Erry ,  Simon C. Woods ,  Paul Harrison

IPC分类号： A61B310

CPC分类号： A61B3/1015 ,  A61B3/107 ,  A61F2/142 ,  G01J9/00

摘要： Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second plano/plano lenses. The first and second plano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than total distortions.

摘要翻译： 用于确定角膜（无论是体外或体内）是否已被修改（手术或其他方式）的装置。 该方法包括以下步骤：将准直光束（相干或非相干）通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 畸变波阵面的分析可以是高阶像差的存在，或表示修改的高斯特性。 更具体地说，该方法包括以下步骤：提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜，在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 该装置包括：准直光源：包括失真光栅和成像透镜（其具有瞳孔平面，第一和第二虚拟平面以及像平面）的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。 用于定位角膜（其浸入合适的储存液体中）的结构包括第一和第二平面/平视镜片。 基本上和垂直于和相对于轴居中的第一和第二平面透镜具有小于总失真。

公开(公告)号：US20020151801A1

公开(公告)日：2002-10-17

申请号：US10115355

申请日：2002-04-02

申请人： Kestrel Corporation

发明人： Leonard John Otten III ,  Gavin R. G. Erry ,  Simon C. Woods ,  Paul Harrison

IPC分类号： A61B006/00

CPC分类号： A61B3/1015 ,  A61B3/107 ,  A61F2/142 ,  G01J9/00

摘要： Apparatus for determining if a cornea (whether in vitro or in vivo) has been modified (either surgically or otherwise). The method includes the steps of: passing a beam of collimated light a (either coherent or incoherent) through the cornea to produce a distorted wavefront; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The analysis of the distorted wavefront can be for the presence of higher order aberrations, or Gausian characteristics which are indicative of modifications. More particularly, the method includes the steps of providing an optical system that has a pupil plane and an image plane at a detector; positioning the cornea in the pupil plane; passing a collimated beam of light through the cornea to produce at least two images in the image plane; determining the characteristics of the distorted wavefront; and analyzing the distorted wavefront for characteristics that identify the presence of a modification. The apparatus includes: a source of collimated light: an optical system including a distorted grating and an imaging lens (which have a pupil plane, first and second virtual planes, and an image plane); structure for positioning the cornea in the pupil plane; and a computer. The structure for positioning the cornea (which is immersed in a suitable storage fluid) includes first and second piano/piano lenses. The first and second piano lens, which are substantially and perpendicular to and centered with respect to the axis, have less than null/10 total distortions.

摘要翻译： 用于确定角膜（无论是体外或体内）是否已被修改（手术或其他方式）的装置。 该方法包括以下步骤：将准直光束（相干或非相干）通过角膜以产生畸变的波前; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 畸变波阵面的分析可以是高阶像差的存在，或表示修改的高斯特性。 更具体地说，该方法包括以下步骤：提供在检测器处具有瞳孔平面和图像平面的光学系统; 将角膜定位在瞳孔平面中; 使准直的光束通过角膜，在图像平面中产生至少两个图像; 确定畸变波前的特征; 并分析畸变波阵面以识别修改的存在的特征。 该装置包括：准直光源：包括失真光栅和成像透镜（其具有瞳孔平面，第一和第二虚拟平面以及像平面）的光学系统; 用于将角膜定位在瞳孔平面中的结构; 和电脑。 用于定位角膜（其浸入合适的储存液体中）的结构包括第一和第二钢琴/钢琴镜片。 第一和第二钢琴镜头基本上和垂直于和相对于轴居中，具有小于lambd / 10的总失真。

公开(公告)号：US06423093B1

公开(公告)日：2002-07-23

申请号：US09626310

申请日：2000-07-26

申请人： Celia R Hicks ,  Geoffrey J Crawford ,  Traian V Chirila ,  Ian J Constable

发明人： Celia R Hicks ,  Geoffrey J Crawford ,  Traian V Chirila ,  Ian J Constable

IPC分类号： A61F214

CPC分类号： A61F2/142 ,  A61F9/007

摘要： Disclosed is a method of insertion of keratoprostheses, and in particular, a method of surgical insertion and placement of a soft hydrogel prosthetic corneal device into the host cornea. The method of the invention provides a greatly improved rate of success for the implantation and retention of the device.

摘要翻译： 公开了一种插入角膜假体的方法，特别是将软水凝胶假体角膜装置手术插入和放置到主体角膜中的方法。 本发明的方法为装置的植入和保持提供了极大的改进的成功率。

公开(公告)号：US06254637B1

公开(公告)日：2001-07-03

申请号：US09546329

申请日：2000-04-10

申请人： Jin Hak Lee ,  Won Ryang Wee ,  Moo Suk Lee

发明人： Jin Hak Lee ,  Won Ryang Wee ,  Moo Suk Lee

IPC分类号： A61F214

CPC分类号： A61F2/142

摘要： An artificial cornea capable of preventing a separation thereof from an eyeball of the patient during an implant operation thereof while avoiding post-operative complications at the interface between the artificial cornea and the patient's cornea, such as erosive tissue necrosis (melting), leakage of aqueous humor, infection, extrusion of the implant, and intraocular inflammation. The artificial cornea includes an artificial cornea body having, at a lower portion thereof, a cylindrical portion adapted to be arranged in the interior of a patient's eyeball, and, at an upper portion thereof, an optical portion adapted to be exposed through an anterior portion of the patient's eyeball, the optical portion having a diameter less than that of the cylindrical portion to define a step at a lower end thereof, a skirt fitted around the optical portion of the cornea body and seated on the step, an anterior flange coupled to an upper surface of the skirt, and a support member attached to a lower end of the cylindrical portion and adapted to support the artificial cornea body. An amnion is covered on the implant in order to promote a stable graft of the artificial cornea to the patient's cornea during an initial reaction period for the recovery of a cut portion of the patient's cornea.

摘要翻译： 一种人造角膜，其能够在其植入操作期间防止其与患者的眼球分离，同时避免在人造角膜和患者角膜之间的界面处的手术后并发症，例如侵蚀性组织坏死（熔化），水分泄漏 幽默，感染，植入物的挤出和眼内炎症。 人造角膜包括人造角膜体，其下部具有适于布置在患者眼球内部的圆柱形部分，并且在其上部具有适于通过前部暴露的光学部分 患者眼球的光学部分的直径小于圆柱形部分的直径，以限定其下端的台阶，围绕角膜体的光学部分安装并位于台阶上的裙部，前凸缘连接到 所述裙部的上表面和附接到所述圆筒形部分的下端并适于支撑所述人造角膜体的支撑构件。 植入物覆盖羊膜，以便在用于恢复患者角膜切割部分的初始反应期间促进人造角膜对患者角膜的稳定移植。

公开(公告)号：US6106552A

公开(公告)日：2000-08-22

申请号：US117104

申请日：1998-07-21

申请人： Emmanuel Lacombe ,  Gilles Bos ,  Franck Villain

发明人： Emmanuel Lacombe ,  Gilles Bos ,  Franck Villain

IPC分类号： A61F2/14

CPC分类号： A61F2/142

摘要： The invention relates to a corneal prosthesis device for putting into place in the cornea. The device comprises an optical part (10) made of a first transparent material and of substantially cylindrical shape presenting an anterior face (14) defining an optical surface and a posterior end (16), an annular anterior skirt (18) projecting from the side wall of the optical part and being made of a biocompatible and biocolonizable synthetic polymer that is distinct from said first material, and a posterior annular skirt (20) projects from the side wall of the optical part and is made of said first material.

摘要翻译： PCT No.PCT / FR97 / 00178 Sec。 371日期：1998年7月21日 102（e）日期1998年7月21日PCT 1997年1月30日PCT PCT。 出版物WO97 / 27824 PCT 日期：1997年8月7日本发明涉及一种用于角膜置入的角膜假体装置。 该装置包括由第一透明材料制成并具有基本上圆柱形形状的光学部件（10），其具有限定光学表面的前表面（14）和后端（16），从侧面突出的环形前裙部 并且由与所述第一材料不同的生物相容性和生物共生性合成聚合物制成，并且后环形裙部（20）从所述光学部件的侧壁突出并且由所述第一材料制成。

公开(公告)号：US6005160A

公开(公告)日：1999-12-21

申请号：US604903

申请日：1996-02-22

申请人： Ging-Ho Hsiue ,  Shyh-Dar Lee ,  Patricia Chuen-Tsuei Chung

发明人： Ging-Ho Hsiue ,  Shyh-Dar Lee ,  Patricia Chuen-Tsuei Chung

IPC分类号： A61L27/40 ,  A61F2/02 ,  A61F2/14

CPC分类号： A61F2/0077 ,  A61F2/142 ,  A61L27/40 ,  Y10S623/92

摘要： This invention is a heterobifunctional artificial cornea or biomedical membrane and novel process for preparing the heterobifunctional artificial cornea. In this method, plasma induced graft polymerization is adopted to provide the surface property modification of polymer materials like silicone or polyurethane. At first, the frontal side of the material is grafted with polyacrylic acid or polymethacrylic acid and then bonded with collagen, or 2-hydroxyethylmethacrylate (HEMA) is grafted alone. A surface which increases the cell attachment and growth can be then developed. Another side of this membrane is grafted with acrylic acid or polymethacrylic acid and then different molecular weights of polyethylene oxide (PEO) is bonded thereto. 2-methacryloyl-oxyethyl phosphoryl chloride (2-MPC) is grafted to the membrane. The copolymer of the 2-methacryl-oyloxyethyl phosphoryl chloride and MPC-co-butyl methacrylate can be used in preparing a special surface which can inhibit the attachments of cells and protein molecules. Thus, a heterobi-functional biomedical membrane can be developed. In this work, the surface characterization of this membrane, in vitro study and animal in vivo study are also investigated. The obtained results exhibit a very good performance. Moreover, it demonstrates that the developed product has good transparency, hydrophilicity and high biocompatibility, thereby exhibiting the high potential in the application field of artificial cornea.

摘要翻译： 本发明是异双功能人造角膜或生物医学膜以及用于制备异双功能人造角膜的新方法。 在这种方法中，采用等离子体诱导接枝聚合来提供聚合物材料如硅树脂或聚氨酯的表面性能改性。 首先，材料的正面用聚丙烯酸或聚甲基丙烯酸接枝，然后与胶原结合，或甲基丙烯酸2-羟基乙酯（HEMA）单独接枝。 然后可以开发增加细胞附着和生长的表面。 该膜的另一侧用丙烯酸或聚甲基丙烯酸接枝，然后将不同分子量的聚环氧乙烷（PEO）键合到其上。 将2-甲基丙烯酰氧基乙基磷酰氯（2-MPC）接枝到膜上。 2-甲基丙烯酰氧基乙基磷酰氯和甲基丙烯酸甲酯共​​聚物的共聚物可用于制备可抑制细胞和蛋白质分子附着的特殊表面。 因此，可以开发异双功能生物医学膜。 在这项工作中，还研究了该膜的表面表征，体外研究和动物体内研究。 获得的结果表现出非常好的性能。 此外，它表明开发的产品具有良好的透明性，亲水性和高生物相容性，从而在人造角膜的应用领域表现出很高的潜力。