公开(公告)号：US06254637B1

公开(公告)日：2001-07-03

申请号：US09546329

申请日：2000-04-10

申请人： Jin Hak Lee ,  Won Ryang Wee ,  Moo Suk Lee

发明人： Jin Hak Lee ,  Won Ryang Wee ,  Moo Suk Lee

IPC分类号： A61F214

CPC分类号： A61F2/142

摘要： An artificial cornea capable of preventing a separation thereof from an eyeball of the patient during an implant operation thereof while avoiding post-operative complications at the interface between the artificial cornea and the patient's cornea, such as erosive tissue necrosis (melting), leakage of aqueous humor, infection, extrusion of the implant, and intraocular inflammation. The artificial cornea includes an artificial cornea body having, at a lower portion thereof, a cylindrical portion adapted to be arranged in the interior of a patient's eyeball, and, at an upper portion thereof, an optical portion adapted to be exposed through an anterior portion of the patient's eyeball, the optical portion having a diameter less than that of the cylindrical portion to define a step at a lower end thereof, a skirt fitted around the optical portion of the cornea body and seated on the step, an anterior flange coupled to an upper surface of the skirt, and a support member attached to a lower end of the cylindrical portion and adapted to support the artificial cornea body. An amnion is covered on the implant in order to promote a stable graft of the artificial cornea to the patient's cornea during an initial reaction period for the recovery of a cut portion of the patient's cornea.

摘要翻译： 一种人造角膜，其能够在其植入操作期间防止其与患者的眼球分离，同时避免在人造角膜和患者角膜之间的界面处的手术后并发症，例如侵蚀性组织坏死（熔化），水分泄漏 幽默，感染，植入物的挤出和眼内炎症。 人造角膜包括人造角膜体，其下部具有适于布置在患者眼球内部的圆柱形部分，并且在其上部具有适于通过前部暴露的光学部分 患者眼球的光学部分的直径小于圆柱形部分的直径，以限定其下端的台阶，围绕角膜体的光学部分安装并位于台阶上的裙部，前凸缘连接到 所述裙部的上表面和附接到所述圆筒形部分的下端并适于支撑所述人造角膜体的支撑构件。 植入物覆盖羊膜，以便在用于恢复患者角膜切割部分的初始反应期间促进人造角膜对患者角膜的稳定移植。

公开(公告)号：US20080300444A1

公开(公告)日：2008-12-04

申请号：US12126346

申请日：2008-05-23

申请人： Sung-Joon Ye ,  IlHan Kim ,  Won Ryang Wee ,  Mee Kum Kim ,  Kwang Jae Son ,  Hyon Soo Han ,  Ul Jae Park ,  Hyeon Young Shin

发明人： Sung-Joon Ye ,  IlHan Kim ,  Won Ryang Wee ,  Mee Kum Kim ,  Kwang Jae Son ,  Hyon Soo Han ,  Ul Jae Park ,  Hyeon Young Shin

IPC分类号： A61M36/04

CPC分类号： A61N5/1001 ,  A61N2005/1089

摘要： Disclosed is an ophthalmic applicator for the treatment of pterygium or or glaucoma using a radioisotope. It comprises a source volume for containing the radioisotope therein; a filter volume for controlling a radiation dose emitted from the radioisotope; and an encapsulation volume for encompassing the source volume and the filter volume, wherein the radioisotope is pure 32P or a combination of 32P and 103Pd. Ensuring the formation of more ideal dose distributions than do the conventional 90Sr ophthalmic applicators, as described hitherto, the ophthalmic applicator for the treatment of pterygium or glaucoma using 32P or a combination of 32P and 103Pd can promise both high therapeutic effects on pterygium or glaucoma and high safety effects on the eye lens. Further, 32P and 103Pd are easier to produce and treat than is 90Sr, thereby allowing the radiotherapy to be useful.

摘要翻译： 公开了一种用于使用放射性同位素治疗翼状ium肉或青光眼的眼科施放器。 它包括用于在其中容纳放射性同位素的源体积; 用于控制从放射性同位素发射的辐射剂量的过滤器体积; 以及用于包围源体积和过滤器体积的封装体积，其中放射性同位素是纯32P或32P和103Pd的组合。 如上所述，确保形成更理想的剂量分布，如迄今所述，用于使用32P或32P和103Pd的组合治疗翼状ium肉或青光眼的眼科施用器可以对翼状ium肉或青光眼有很高的治疗效果， 对眼睛镜片的高安全性影响。 此外，32P和103Pd比90Sr更容易产生和治疗，从而允许放射治疗是有用的。

公开(公告)号：US20110183404A1

公开(公告)日：2011-07-28

申请号：US12596087

申请日：2009-10-15

申请人： Won-Ryang Wee ,  Mee-Kum Kim ,  Joo-Youn Oh

发明人： Won-Ryang Wee ,  Mee-Kum Kim ,  Joo-Youn Oh

IPC分类号： C07G15/00

CPC分类号： A61K35/44 ,  A01N1/0226 ,  A61F2/142 ,  A61L27/3604 ,  A61L27/3687 ,  A61L2430/16 ,  A61L2430/40

摘要： Disclosed is a method for processing porcine cornea using an aqueous NaCl solution and an aqueous trypsin/EDTA solution to decellularize enucleated porcine cornea. The porcine cornea processed by the method causes neither inflammation nor immune rejection. The porcine corneal stroma decellularized by the method can be recellularized together with host keratocytes after transplantation.

摘要翻译： 本发明公开了一种使用NaCl水溶液和胰蛋白酶/ EDTA水溶液对去角质去角质猪角膜进行脱细胞处理猪角膜的方法。 通过该方法处理的猪角膜既不引起炎症也不引起免疫排斥。 通过该方法脱细胞化的猪角膜基质可以与移植后的宿主角膜细胞一起被收集。

公开(公告)号：US08313893B2

公开(公告)日：2012-11-20

申请号：US12596087

申请日：2009-10-15

申请人： Won-Ryang Wee ,  Mee-Kum Kim ,  Joo-Youn Oh

发明人： Won-Ryang Wee ,  Mee-Kum Kim ,  Joo-Youn Oh

IPC分类号： A01N1/00 ,  A61F2/14

CPC分类号： A61K35/44 ,  A01N1/0226 ,  A61F2/142 ,  A61L27/3604 ,  A61L27/3687 ,  A61L2430/16 ,  A61L2430/40

摘要： Disclosed is a method for processing porcine cornea using an aqueous NaCl solution and an aqueous trypsin/EDTA solution to decellularize enucleated porcine cornea. The porcine cornea processed by the method causes neither inflammation nor immune rejection. The porcine corneal stroma decellularized by the method can be recellularized together with host keratocytes after transplantation.

摘要翻译： 本发明公开了一种使用NaCl水溶液和胰蛋白酶/ EDTA水溶液对去角质去角质猪角膜进行脱细胞处理猪角膜的方法。 通过该方法处理的猪角膜既不引起炎症也不引起免疫排斥。 通过该方法脱细胞化的猪角膜基质可以与移植后的宿主角膜细胞一起被收集。