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公开(公告)号：US20230270822A1
公开(公告)日：2023-08-31
申请号：US18181852
申请日：2023-03-10
Applicant: Spectrum Pharmaceuticals Inc. , Hanmi Pharmaceutical
Inventor： Gajanan Bhat , Shanta Chawla , Jae Hyuk Choi , Eun jung Kim , Yu Yon Kim , Gyu Hyan Lee , Hyesun Han
CPC classification number: A61K38/193 , A61K47/60 , C07K16/46 , C07K2317/528 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/53
Abstract: This disclosure provides a method of preventing, alleviating or treating a condition (i.e., neutropenia) in a subject in need thereof, the condition characterized by compromised white blood cell production in the subject. The method includes administering to the subject a therapeutically effective amount of a protein complex on the same day as a chemotherapy regimen, wherein the protein complex is a modified human granulocyte-colony stimulating factor (hG-CSF) covalently linked to an immunoglobulin Fc region via a non-peptidyl polymer. The non-peptidyl polymer is site-specifically linked to an N-terminus of the immunoglobulin Fc region, and the modified hG-CSF comprises substitutions in at least one of Cys17 and Pro65.
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公开(公告)号：US11673972B2
公开(公告)日：2023-06-13
申请号：US17124371
申请日：2020-12-16
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , C07K16/2809 , C07K16/2818 , C07K16/2896 , C07K16/30 , C07K16/3061 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号：US20190218275A1
公开(公告)日：2019-07-18
申请号：US16226964
申请日：2018-12-20
Applicant: University of Maryland, Baltimore , Gliknik Inc.
Inventor： Scott E. STROME , Dan H. SCHULZE , David S. BLOCK , Henrik OLSEN
CPC classification number: C07K16/00 , A61K2039/505 , A61K2039/54 , A61K2039/57 , C07K16/065 , C07K16/18 , C07K16/28 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/35 , C07K2317/41 , C07K2317/50 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/92 , C07K2318/00 , C07K2319/00 , C07K2319/30 , G01N33/5047 , G01N2500/10 , Y02A50/412
Abstract: IVIG replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacement compound's efficiency at modulating immune function. Particular replacement compounds are selected for further in vivo validation and dosage/administration optimization. Finally, the replacement compounds are used to treat a wide range of diseases, including inflammatory and autoimmune diseases
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公开(公告)号：US20190211081A1
公开(公告)日：2019-07-11
申请号：US16298032
申请日：2019-03-11
Applicant: Chugai Seiyaku Kabushiki Kaisha
Inventor： Tomoyuki Igawa , Taichi Kuramochi , Atsuhiko Maeda , Hirotake Shiraiwa
CPC classification number: C07K16/00 , C07K16/2866 , C07K16/2875 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/53 , C07K2317/71 , C07K2317/72 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region.
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公开(公告)号：US20190202938A1
公开(公告)日：2019-07-04
申请号：US16354058
申请日：2019-03-14
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/3061 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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Patent Agency Ranking
公开(公告)号：US20180244804A1
公开(公告)日：2018-08-30
申请号：US15559358
申请日：2016-03-18
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Lynn MACDONALD , Andrew J. MURPHY , Cagan GURER , Robert BABB
IPC: C07K16/46 , C07K16/28 , A01K67/027
CPC classification number: C07K16/468 , A01K67/0278 , A01K2217/072 , A01K2217/15 , A01K2227/105 , A01K2267/01 , C07K16/00 , C07K16/28 , C07K16/462 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/53 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/569 , C07K2317/622 , C07K2317/92
Abstract: Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise an immunoglobulin heavy chain locus that includes unrearranged human immunoglobulin light chain gene segments and an immunoglobulin light chain locus that includes a single rearranged human light chain variable region nucleotide sequence. The unrearranged human light chain gene segments may be operably linked to a heavy chain constant region nucleotide sequence and the rearranged human immunoglobulin light chain variable region nucleotide sequence may be operably linked to a light chain constant region nucleotide sequence. Also provided are methods for obtaining nucleic acid sequences that encode immunoglobulin light chain variable domains capable of binding an antigen in the absence of a cognate variable domain, and expressing such nucleic acid sequences in a host cell, e.g., to generate a multispecific antigen-binding protein.
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公开(公告)号：US20180223000A1
公开(公告)日：2018-08-09
申请号：US15945681
申请日：2018-04-04
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/2866 , C07K16/2887 , C07K16/2896 , C07K16/30 , C07K16/3061 , C07K16/40 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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公开(公告)号：US20180215827A1
公开(公告)日：2018-08-02
申请号：US15832337
申请日：2017-12-05
Applicant: GENMAB A/S
Inventor： Bart DE GOEIJ , Simone DE HAIJ , Thilo RIEDL , Rene HOET , Ole BAADSGAARD , Jan VAN DE WINKEL , David SATIJN , Paul PARREN , Aran Frank LABRIJN , Joyce MEESTERS , Janine SCHUURMAN , Edward N. VAN DEN BRINK
CPC classification number: C07K16/2863 , A61K2039/505 , C07K16/2809 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/77 , C07K2317/92
Abstract: Isolated monoclonal antibodies which bind to human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and therapeutic and diagnostic methods for using the antibodies are also disclosed.
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公开(公告)号：US09815891B2
公开(公告)日：2017-11-14
申请号：US14848636
申请日：2015-09-09
Applicant: Robert Poppe
Inventor： Robert Poppe
IPC: A61K39/395 , C07K19/00 , C07K16/18 , C07K16/00 , G01N33/68
CPC classification number: C07K16/18 , C07K16/00 , C07K2317/14 , C07K2317/35 , C07K2317/41 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/528 , C07K2317/569 , C07K2317/622 , C07K2317/64 , G01N33/6854
Abstract: The present invention relates to a novel antigen-binding protein construct or “modubody”, which contains at least three functional single domain modules of an antibody. The modubodies contain a domain from the heavy chain variable region of an antibody (VH), a domain from the light chain variable region of an antibody (VL) and bind monospecifically to an antigen. The modubodies further contain a domain from the constant region of antibodies. The modubodies can be used for diagnostic or therapeutic purposes.
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公开(公告)号：US20170081420A1
公开(公告)日：2017-03-23
申请号：US15185958
申请日：2016-06-17
Applicant: Xencor, Inc.
Inventor： Matthew J. Bernett , Gregory Moore , John Desjarlais , Seung Chu , Rumana Rashid , Umesh Muchhal , Sung-Hyung Lee
CPC classification number: C07K16/468 , A61K2039/505 , C07K16/2809 , C07K16/2818 , C07K16/2896 , C07K16/30 , C07K16/3061 , C07K2317/24 , C07K2317/31 , C07K2317/35 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/526 , C07K2317/528 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/60 , C07K2317/622 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
Abstract: The present invention is directed to novel heterodimeric antibodies.
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