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公开(公告)号：US11590171B2
公开(公告)日：2023-02-28
申请号：US17725478
申请日：2022-04-20
IPC分类号： A61K35/17 , C07K14/725 , C12N9/22 , C12N15/113 , C12N15/85 , C12N15/90
摘要： Provided herein are methods and compositions for editing the genome of a human T cell. In some embodiments, a heterologous T cell receptor (TCR)-β chain and a heterologous TCR-α chain are inserted into exon 1 of a TCR subunit constant gene in the genome of the T cell.
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公开(公告)号：US20230053398A1
公开(公告)日：2023-02-23
申请号：US17821536
申请日：2022-08-23
发明人： Julio L. Vergara , Daniel M. Estrada , Mayank Kalra , Andrew Padula , Daniel E. Cuadra , Ryan C. Cohn
摘要： A heat exchange module having a heat transfer fluid channel and a heat transfer plate in heat transfer relation with fluid in the channel. The reference side of a thermoelectric cooler (TEC) is in thermal contact with the plate. A heat transfer tile is in thermal contact with a user side of the TEC. The module is configured to be operatively positionable with the tile in heat transfer relation with skin of a patient.
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公开(公告)号：US11589164B2
公开(公告)日：2023-02-21
申请号：US17266539
申请日：2019-08-06
摘要： This disclosure provides systems, methods, and apparatus related to acoustic transducers.
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公开(公告)号：US11583311B2
公开(公告)日：2023-02-21
申请号：US16921604
申请日：2020-07-06
发明人： Krystof Bankiewicz
摘要： The use of stepped cannulas, wherein a step structure creates a backstop to reduce backflow along the cannula body, is known for convection enhanced delivery of agents to the brain and other structures within an animal. Described herein are novel and improved stepped cannula designs wherein the length of the cannula segment between the step and the dispensing outlet is variable and can be controllably adjusted inside the patient during delivery. This advantageously allows the operator to place the cannula step at the optimal position and deliver agents at one or more positions within the target structure.
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公开(公告)号：US20230053166A1
公开(公告)日：2023-02-16
申请号：US17759130
申请日：2021-01-22
摘要： The disclosure provides methods of managing opioid therapy, particularly, for pain management. The methods comprise determining in a subject, for example, a subject who has received an opioid treatment, pupillary unrest in ambient light (PUAL). Low values of PUAL can be used to identify patients at risk for opioid side-effects, such as opioid-related respiratory depression (OIRD), and who warrant attention to prevent such side effects. Accordingly, the methods include monitoring the patients having low values of PUAL for signs of adverse side-effects and/or limiting or avoiding administration of opioids.
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公开(公告)号：US20230052740A1
公开(公告)日：2023-02-16
申请号：US17638172
申请日：2020-08-27
申请人： The Regents of the University of California , The University of North Carolina at Chapel Hill , The Research Foundation for the State University of New York
发明人： Brian K. Shoichet , Reed M. Stein , Margarita L. Dubocovich , Grant C. Glatfelter , Bryan L. Roth , Hye Jin Kang
IPC分类号： A61K31/435 , A61P25/20
摘要： Disclosed herein are, inter alia, compounds modulating MT1 and MT2 receptors' activity and methods of use thereof for treating MT1 and MT2 receptor-related conditions.
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公开(公告)号：US20230045859A1
公开(公告)日：2023-02-16
申请号：US17758625
申请日：2021-01-25
发明人： Eran Halperin , Nadav Rakocz , Jeffrey Chiang , Muneeswar Gupta , Srinivas Sadda
摘要： Deep learning methods and systems for detecting biomarkers within optical coherence tomography volumes using such deep learning methods and systems are provided. Embodiments predict the presence or absence of clinically useful biomarkers in OCT images using deep neural networks. The lack of available training data for canonical deep learning approaches is overcome in embodiments by leveraging a large external dataset consisting of foveal scans using transfer learning. Embodiments represent the three-dimensional OCT volume by “tiling” each slice into a single two dimensional image, and adding an additional component to encourage the network to consider local spatial structure. Methods and systems, according to embodiments are able to identify the presence or absence of AMD-related biomarkers on par with clinicians. Beyond identifying biomarkers, additional models could be trained, according to embodiments, to predict the progression of these biomarkers over time.
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公开(公告)号：US11576871B2
公开(公告)日：2023-02-14
申请号：US16461361
申请日：2016-11-16
发明人： Ranjan Dohil
IPC分类号： A61K9/48 , A61K9/20 , A61K9/28 , A61K31/145
摘要： The disclosure provides cysteamine salt and cystamine formulations comprising enteric coatings. The disclosure also provides composition for use in treating diseases and disorders that can be treated with cysteamine.
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公开(公告)号：US11576744B2
公开(公告)日：2023-02-14
申请号：US17703238
申请日：2022-03-24
发明人： Ralph V. Clayman , Pengbo Jiang , Mark Schoenberg , Omer Tsipori
摘要： Provided herein are methods for treating nephrolithiasis and protecting the urothelium and inner lining of the kidney from thermal damage during lithotripsy by use of a thermosensitive bio-adhesive hydrogel. The described method dramatically improved the efficiency and effectiveness of stone clearance compared to conventional techniques while providing protection to the urothelium from potentially damaging temperature spikes.
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公开(公告)号：US20230040805A1
公开(公告)日：2023-02-09
申请号：US17851871
申请日：2022-06-28
IPC分类号： A61K9/48 , A61P3/10 , A61P35/04 , A61K38/26 , A61K38/28 , A61K47/12 , A61K47/18 , A61K31/201 , A61K31/14
摘要： The technology described herein is directed to compositions comprising CAGE and at least one active compound, e.g., for oral or parenteral administration.
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