公开(公告)号：US20200157504A1

公开(公告)日：2020-05-21

申请号：US16776765

申请日：2020-01-30

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/0789 ,  A61K35/28 ,  C12N9/22 ,  C12N15/90 ,  C12N5/077 ,  C12N9/16 ,  C12P21/00 ,  C12N15/87 ,  H01L31/048 ,  C08K5/5399 ,  C12N5/074

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20200147239A1

公开(公告)日：2020-05-14

申请号：US16710771

申请日：2019-12-11

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61K9/00 ,  C12N9/22 ,  C07K14/00 ,  A61P3/10 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00 ,  A61P3/00 ,  A61P11/00 ,  A61P3/06 ,  A61P1/16 ,  A61K31/7115

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20200056207A1

公开(公告)日：2020-02-20

申请号：US16654726

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  A61K38/46 ,  C07K14/195 ,  A61K35/14 ,  A61K48/00 ,  C12N9/22 ,  C12N15/10 ,  C12N15/86 ,  G01N33/50 ,  A61K31/7115

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200040364A1

公开(公告)日：2020-02-06

申请号：US16657318

申请日：2019-10-18

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  G01N33/50 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K31/7115 ,  A61K38/46 ,  C12N15/10 ,  A61K48/00 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200032297A1

公开(公告)日：2020-01-30

申请号：US16655744

申请日：2019-10-17

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K38/46 ,  G01N33/50 ,  C12N15/10 ,  A61K48/00 ,  A61K31/7115 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20190307897A1

公开(公告)日：2019-10-10

申请号：US16441622

申请日：2019-06-14

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61P3/06 ,  C07K14/00 ,  C12N9/22 ,  A61P3/10 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00 ,  A61P3/00 ,  A61P11/00 ,  A61P1/16 ,  A61K31/7115 ,  A61K9/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US10363321B2

公开(公告)日：2019-07-30

申请号：US16030674

申请日：2018-07-09

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61P3/10 ,  A61K48/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/06 ,  A61P11/00 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/00 ,  C12N9/22 ,  A61K9/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US10350304B2

公开(公告)日：2019-07-16

申请号：US16030670

申请日：2018-07-09

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61P3/10 ,  A61K48/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/06 ,  A61P11/00 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/00 ,  C12N9/22 ,  A61K9/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US10137206B2

公开(公告)日：2018-11-27

申请号：US15881721

申请日：2018-01-26

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61K48/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/06 ,  A61P11/00 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P3/10 ,  C07K14/00 ,  C12N9/22

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20180271951A1

公开(公告)日：2018-09-27

申请号：US16006461

申请日：2018-06-12

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K38/39 ,  C12N15/87 ,  A61B18/18 ,  A61Q19/06 ,  A61Q19/00 ,  A61M35/00 ,  A61Q19/08 ,  A61K8/60 ,  A61K9/00 ,  A61K9/127 ,  A61K48/00 ,  A61K47/46 ,  A61K45/06 ,  A61K38/45 ,  A61K38/44 ,  A61K38/38 ,  A61K31/713 ,  A61K31/711 ,  A61K31/7105 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/575 ,  A61K31/573 ,  A61B18/00

CPC classification number: A61K38/39 ,  A61B18/18 ,  A61B2018/00452 ,  A61B2018/1807 ,  A61K8/606 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/127 ,  A61K31/573 ,  A61K31/575 ,  A61K31/7068 ,  A61K31/7072 ,  A61K31/7105 ,  A61K31/711 ,  A61K31/713 ,  A61K38/38 ,  A61K38/44 ,  A61K38/45 ,  A61K45/06 ,  A61K47/46 ,  A61K48/00 ,  A61K48/005 ,  A61K2800/83 ,  A61K2800/91 ,  A61M35/00 ,  A61Q19/00 ,  A61Q19/008 ,  A61Q19/06 ,  A61Q19/08 ,  C12N15/87 ,  A61K2300/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules, including cells present in vivo. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.