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公开(公告)号：US11814333B2
公开(公告)日：2023-11-14
申请号：US17553564
申请日：2021-12-16
IPC分类号： C07C215/24 , A61K9/127
CPC分类号： C07C215/24 , A61K9/1272
摘要： The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
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公开(公告)号：US11692203B2
公开(公告)日：2023-07-04
申请号：US16913306
申请日：2020-06-26
发明人： Matthew Angel , Christopher Rohde
IPC分类号： C12N15/85 , C12N15/87 , C08K5/5399 , C12N5/074 , H01L31/048 , C12P21/00 , C12N9/16 , C12N5/0789 , C12N5/077 , C12N15/90 , C12N9/22 , A61K35/28 , C08G77/08 , A61K35/12
CPC分类号： C12N15/87 , A61K35/28 , C08K5/5399 , C12N5/0647 , C12N5/0657 , C12N5/0696 , C12N9/16 , C12N9/22 , C12N15/907 , C12P21/00 , C12Y301/21 , H01L31/048 , A61K2035/124 , C08G77/08 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , Y02E10/50 , C08K5/5399 , C08L83/04 , C08L83/04 , C08K5/5399
摘要： The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US10894092B2
公开(公告)日：2021-01-19
申请号：US16441622
申请日：2019-06-14
发明人： Matthew Angel , Christopher Rohde
IPC分类号： A61K48/00 , A61K31/7115 , A61P1/16 , A61P3/06 , A61P11/00 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P3/10 , C07K14/00 , C12N9/22 , A61K9/00
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US10590437B2
公开(公告)日：2020-03-17
申请号：US16523558
申请日：2019-07-26
发明人： Matthew Angel , Christopher Rohde
IPC分类号： C07H21/04 , A61K31/70 , C12N9/22 , C12N15/90 , A61K31/7115 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US10576167B2
公开(公告)日：2020-03-03
申请号：US15748132
申请日：2017-08-17
发明人： Matthew Angel , Christopher Rohde
IPC分类号： A61K48/00 , A61K31/7115 , A61P1/16 , A61P3/06 , A61P11/00 , A61P3/00 , A61P9/00 , A61P29/00 , A61P35/00 , A61P3/10 , C07K14/00 , C12N9/22 , A61K9/00
摘要： The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
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公开(公告)号：US10556855B1
公开(公告)日：2020-02-11
申请号：US16660299
申请日：2019-10-22
IPC分类号： C07C215/24 , A61K9/127
摘要： The present invention relates in part to novel cationic lipids and their use, e.g., in delivering nucleic acids to cells.
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公开(公告)号：US10443045B2
公开(公告)日：2019-10-15
申请号：US16374482
申请日：2019-04-03
发明人： Matthew Angel , Christopher Rohde
摘要： The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.
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公开(公告)号：US10415060B2
公开(公告)日：2019-09-17
申请号：US15670639
申请日：2017-08-07
发明人： Matthew Angel , Christopher Rohde
IPC分类号： C07H21/04 , C12N15/00 , C12N15/90 , A61K31/7115 , C12N9/22 , C07K14/195 , C12N15/10 , A61K35/14 , A61K38/46 , A61K48/00 , C12N15/86 , G01N33/50 , A01K67/00 , A61K35/12
摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US20170362612A1
公开(公告)日：2017-12-21
申请号：US15670639
申请日：2017-08-07
发明人： Matthew Angel , Christopher Rohde
CPC分类号： C12N15/907 , A61K31/7115 , A61K35/14 , A61K38/465 , A61K48/005 , A61K2035/124 , C07K14/195 , C07K2319/80 , C12N9/22 , C12N15/1024 , C12N15/86 , C12N2800/80 , C12Y301/00 , C12Y301/21004 , G01N33/5014
摘要： The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.
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公开(公告)号：US20170152483A1
公开(公告)日：2017-06-01
申请号：US15429795
申请日：2017-02-10
发明人： Matthew Angel , Christopher Rohde
IPC分类号： C12N5/0789 , C12N15/90 , C12N9/22
CPC分类号： C12N5/0647 , A61K35/28 , A61K2035/124 , C08G77/08 , C08K5/5399 , C12N5/0657 , C12N9/16 , C12N9/22 , C12N15/87 , C12N15/907 , C12N2500/25 , C12N2500/44 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/2303 , C12N2501/26 , C12N2501/91 , C12N2501/998 , C12N2506/09 , C12N2800/80 , C12P21/00 , C12Y301/21 , H01L31/048 , Y02E10/50 , C08L83/04
摘要： The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.
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