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公开(公告)号：US11565091B2
公开(公告)日：2023-01-31
申请号：US16461383
申请日：2017-11-16
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Ofer Barnea , Omer Doron
IPC: A61M27/00 , A61M25/10 , A61M25/00 , A61B5/03 , A61M60/122 , A61M60/268
Abstract: A method for influencing cerebral perfusion in a patient by modifying a volume of a volume adaptor introduced into a cerebral ventricle of the patient, the method comprising identifying a timing of a cerebral blood inflow and/or outflow in a cardiac activity of the patient, modifying a volume of the volume adaptor in synchronization to the identified timing of the cerebral blood flow, to an amount sufficient to modify an intracranial pressure in the cerebral ventricle, such that a flow of the cerebral blood flow is enhanced. In some exemplary embodiments of the invention, the inflation duration of the volume adapter is short relative to the cardiac cycle.
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公开(公告)号：US20220213445A1
公开(公告)日：2022-07-07
申请号：US17613137
申请日：2020-05-22
Inventor： Benjamin Eithan REUBINOFF , Michal GROPP
IPC: C12N5/074 , C12N5/0735 , C12N5/073
Abstract: A culture of human pluripotent stem cells (hPSCs) is disclosed. In the culture, more than 50% of the hPSCs are formative hPSCs and are capable of renewing. Uses thereof are also disclosed.
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公开(公告)号：US11273201B2
公开(公告)日：2022-03-15
申请号：US16392685
申请日：2019-04-24
Inventor： Dina Ben Yehuda , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: C12N15/85 , A61K38/17 , C12N5/078 , C12N5/0789 , A61K45/06 , A61K35/28 , A61K35/545
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
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公开(公告)号：US11246912B2
公开(公告)日：2022-02-15
申请号：US16641517
申请日：2018-08-30
Inventor： Rinat Abramovitch , Esther Goldlist
IPC: A61K38/22 , G01N33/574 , A61P35/04 , C12Q1/6886 , G01N33/74
Abstract: The present invention is directed to a method for treating or preventing cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an adropin stimulating agent. Further provided are a method and a kit for diagnosing or prognosing liver metastases in a subject.
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公开(公告)号：US20210369107A1
公开(公告)日：2021-12-02
申请号：US17404171
申请日：2021-08-17
Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
Inventor： Jose COHEN , Vladimir GOLDMAN , Yousef Nadim FARRAJ , Amnon BUXBOIM , Yoav MINTZ , Elchanan FRIED , Gahl LEVY , Tsevi BEATUS , Yoav KAN-TOR
Abstract: Devices and method for determining a pupil size of a subject having closed eyelids.
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Patent Agency Ranking
公开(公告)号：US11161912B2
公开(公告)日：2021-11-02
申请号：US15767355
申请日：2016-10-13
Applicant: Technion Research & Development Foundation Limited , Hadasit Medical Research Services and Development Ltd.
Inventor： Israel Vlodavsky , Marina Weissmann , Neta Ilan , Gil Arvatz
IPC: C07K16/40 , C12N9/24 , A61P31/00 , A61P35/04 , A61P35/00 , A61K39/395 , A61K45/06 , C07K16/30 , A61K39/00
Abstract: The present invention relates to heparanase-neutralizing monoclonal antibodies (m Abs), pharmaceutical composition comprising same, and use thereof for treating a disease or disorder associated with heparanase activity, including but not limited to cancer, inflammation, diabetes and related complications. The present invention further provides combined therapies comprising the heparanase-neutralizing m Ab and an anti-cancer treatment such as chemotherapy or radiation, for treating a proliferative disease in a subject.
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公开(公告)号：US20210298949A1
公开(公告)日：2021-09-30
申请号：US17265637
申请日：2019-08-05
Inventor： Itay CHOWERS , Tomer BATASH
Abstract: There is provided herein a multi-lumen syringe for intraocular injection, including a first lumen, a second lumen, one or more needles fluidly connected to the lumens, and a needle sheath disposed about the one or more needles; wherein the needle sheath includes a plurality of n proximity/contact/pressure actuators on a distal rim of the needle sheath; wherein the syringe is switchable between at least two configurations: a first configuration in which at least one of the actuators is not actuated and each tip of the one or more needles is proximally positioned, and secured, relative to the distal rim; and a second configuration in which the n actuators are actuated, and the one or more needles are allowed to distally extend beyond the distal rim.
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公开(公告)号：US10940241B2
公开(公告)日：2021-03-09
申请号：US16616418
申请日：2018-05-31
Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services , Hadasit Medical Research Services and Development Ltd. , Mitchell Shirvan
Inventor： Pamela Gehron Robey , Sergei Kuznetsov , Raphael Gorodetsky , Astar Hailu-Lazmi , Mitchell Shirvan , Joseph Featherall
Abstract: Methods are provided for promoting cartilage growth and/or repair. The methods include, administering locally to a site in a subject in need thereof, bone marrow stromal cells attached to fibrin microbeads comprising crosslinked hyaluronic acid and thereby producing stable cartilage locally at the site in the subject.
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公开(公告)号：US20210015889A1
公开(公告)日：2021-01-21
申请号：US17035829
申请日：2020-09-29
Applicant: Yeda Research and Development Co. Ltd. , Hadasit Medical Research Services and Development Ltd.
Inventor： Ilana KOLODKIN-GAL , Alona KEREN-PAZ , Eitan KEREM , Gideon ZAMIR , Dror KOLODKIN-GAL , Malena COHEN-CYMBERKNOH
Abstract: Methods of disrupting a biofilm and/or preventing formation of a biofilm are provided. Accordingly there is provided a method of reducing or preventing formation of a biofilm and/or disrupting a biofilm comprising contacting a biofilm-producing microorganism with a carbonic anhydrase inhibitor; a urease inhibitor; a Ca2+ ATPase inhibitor; a tlp activator; and/or a myo-inositol catabolism pathway activator. Also provided are articles of manufacture and methods of treating a medical condition in which disrupting a biofilm and/or preventing formation of same is beneficial and methods of predicting or increasing sensitivity to an anti-microbial agent.
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公开(公告)号：US20210008169A1
公开(公告)日：2021-01-14
申请号：US16641517
申请日：2018-08-30
Inventor： Rinat ABRAMOVITCH , Esther GOLDLIST
IPC: A61K38/22 , G01N33/574 , G01N33/74 , A61P35/04 , C12Q1/6886
Abstract: The present invention is directed to a method for treating or preventing cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an adropin stimulating agent. Further provided are a method and a kit for diagnosing or prognosing liver metastases in a subject.
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