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公开(公告)号：US20150125430A1
公开(公告)日：2015-05-07
申请号：US14534394
申请日：2014-11-06
Inventor： Dina BEN YEHUDA , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: A61K38/17 , A61K45/06 , A61K35/14 , C12N5/078 , C12N5/0789
CPC classification number: A61K38/1761 , A61K35/28 , A61K35/545 , A61K45/06 , C12N5/0644 , C12N5/0647 , C12N2501/48 , C12N2501/727 , C12N2501/999
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
Abstract translation: 提供诱导血小板生成和/或治疗受试者血小板减少症的方法。 因此，提供了一种方法，其包括使干细胞与由Livin衍生的血小板或造血祖细胞的分化潜能接触，从而诱导血小板生成。 还提供了一种方法，其包括使具有分化潜力的细胞与血小板与tLivin接触，从而诱导血小板生成。 还提供了用于在受试者中诱导血小板生成和/或治疗血小板减少症的组合物和分离的细胞群。
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公开(公告)号：US10307462B2
公开(公告)日：2019-06-04
申请号：US14534394
申请日：2014-11-06
Inventor： Dina Ben Yehuda , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: A61K39/00 , A61K38/17 , C12N5/078 , C12N5/0789 , A61K45/06 , A61K35/28 , A61K35/545
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
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公开(公告)号：US11273201B2
公开(公告)日：2022-03-15
申请号：US16392685
申请日：2019-04-24
Inventor： Dina Ben Yehuda , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: C12N15/85 , A61K38/17 , C12N5/078 , C12N5/0789 , A61K45/06 , A61K35/28 , A61K35/545
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
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公开(公告)号：US20190247464A1
公开(公告)日：2019-08-15
申请号：US16392685
申请日：2019-04-24
Inventor： Dina Ben Yehuda , Ihab Abd-Elrahman , Riki Perlman , Marjorie Pick
IPC: A61K38/17 , C12N5/0789 , A61K45/06 , A61K35/545 , C12N5/078 , A61K35/28
CPC classification number: A61K38/1761 , A61K35/28 , A61K35/545 , A61K45/06 , C12N5/0644 , C12N5/0647 , C12N2501/48 , C12N2501/727 , C12N2501/999
Abstract: Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with Livin, thereby inducing thrombopoiesis. Also provided is a method comprising contacting cells with a differentiation potential towards platelets with tLivin, thereby inducing thrombopoiesis. Also provided are compositions and isolated population of cells for inducing thrombopoiesis and/or treating thrombocytopenia in a subject.
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