公开(公告)号：US10550400B2

公开(公告)日：2020-02-04

申请号：US15536191

申请日：2015-12-15

申请人： Paris Sciences et Lettres—Quartier Latin ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS)

发明人： Lionel Navarro ,  Odon Thiebeauld

IPC分类号： C12N15/82 ,  C12N15/113 ,  C12N15/65

摘要： The invention relates to transgenic plants comprising an inverted-repeat construct which triggers post-transcriptional gene silencing of an endogenous visual reporter gene driven by a tissue-specific promoter wherein said tissue is relevant for pathogen entry, propagation or replication and their uses for screening natural or synthetic molecules, microorganisms or extracts from micro- or macro-organisms for their potential ability to inhibit pathogen entry, propagation or replication in plants by enhancing PTGS or for characterizing the mode of action of natural or synthetic molecules that are known to enhance plant disease resistance through an ill-defined mode of action.

公开(公告)号：US10533046B2

公开(公告)日：2020-01-14

申请号：US15502469

申请日：2015-08-10

申请人： INTERNATIONAL—DRUG—DEVELOPMENT—BIOTECH ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  HOSPICES CIVILS DE LYON ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE LEON BERARD

发明人： Marie Alexandra Albaret ,  Jean-Jacques Diaz ,  Hichem Claude Mertani ,  Jean-Christophe Saurin ,  Claudine Vermot-Desroches ,  Boris Vuillermoz

IPC分类号： C07K16/18 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395 ,  C07K7/06 ,  A61K39/00 ,  A61K45/06 ,  G01N33/574

摘要： The present disclosure relates to a human CK8 antigen peptide, an antibody, or antibody fragment thereof, or a humanized antibody, specifically binding the peptide having the amino acid sequence of SEQ ID No. 29, a fragment of CK-8. Said molecules can be used use in the detection and/or treatment of tumors whose cells express CK8 protein, in particular the peptide of sequence according to SEQ ID No.29, on their surface.

公开(公告)号：US20200010576A1

公开(公告)日：2020-01-09

申请号：US16329423

申请日：2016-09-05

申请人： Sorbonne Universite ,  Centre National De La Recherche Scientifique ,  Institut National De La Sante Et De La Recherche Medicale (INSERM) ,  Assistance Publique - Hopitaux De Paris ,  Universite Paris Descartes

发明人： Matthieu SOLLOGOUB ,  Vincent CALVEZ ,  Anne-Geneviève MARCELIN ,  Laurent BOUTEILLER ,  Mickaël MENAND ,  Pierre EVENOU ,  Adélie GOTHLAND ,  Dmitri COLESNIC ,  Julien ROSSIGNOL

IPC分类号： C08B37/16 ,  A61K47/69 ,  C12N15/113

摘要： The invention relates to a capped cyclodextrin-hydrophobic moiety conjugate, to a supramolecular polymer formed of capped cyclodextrin-hydrophobic moiety conjugates according to the invention and to a siRNA-cyclodextrin complex comprising a supramolecular polymer according to the invention. The invention also relates to a method for manufacturing the capped cyclodextrin-hydrophobic moiety conjugate, the supramolecular polymer, the siRNA-cyclodextrin complex according to the invention. The capped cyclodextrin-hydrophobic moiety conjugate of the invention comprises a capped cyclodextrin group and at least one hydrophobic moiety bound by a first linker to one of the carbon atoms of the cap. The invention can be used for various applications in particular in the pharmaceutical field.

公开(公告)号：US10519503B2

公开(公告)日：2019-12-31

申请号：US15386571

申请日：2016-12-21

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： Hamid Azzedine ,  Alexis Brice ,  Giovanni Stevanin ,  Filippo Santorelli ,  Paola Denora

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C12Q1/6883

摘要： An ex vivo method of diagnosing or predicting an hereditary spastic paraplegias (HSP) in a subject is provided which comprises detecting a mutation in the KIAA1840 gene or protein (spatacsin), wherein that mutation is indicative of an hereditary spastic paraplegias (HSP).

公开(公告)号：US20190388557A1

公开(公告)日：2019-12-26

申请号：US16308740

申请日：2017-06-09

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE NANTES ,  CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

发明人： Mathieu MEVEL ,  David DENIAUD ,  Eduard AYUSO

IPC分类号： A61K47/69 ,  C12N7/00 ,  A61K49/18 ,  A61K48/00

摘要： The invention is directed to the field of gene therapy, i.e. gene delivery into target cells, tissue, organ and organism, and more particularly to gene delivery via viral vectors. The inventors showed that it is possible by chemical coupling to modulate the coupling of a ligand in the surface of the capsid of AAV, for example AAV2 and AAV3b. In particular, the present invention relates to a recombinant Adeno-Associated Virus (rAAV) vector particle having at least one primary amino group contained in the capsid proteins, chemically coupled with at least one ligand L, wherein coupling of said ligand L is implemented through a bond comprising a —CSNH— bond and an optionally substituted aromatic moiety. Particularly, the inventors tested the chemical coupling of mannose ligand on AAV2 for subretinally injection to rats. The present invention further relates to a method for chemically coupling an Adeno-Associated Virus (AAV) vector particle with at least one ligand L and to a Recombinant Adeno-Associated Virus (rAAV) vector particle obtained by said method as well as a pharmaceutical composition comprising it and their corresponding medical use.

公开(公告)号：US10457665B2

公开(公告)日：2019-10-29

申请号：US15762878

申请日：2016-09-23

申请人： Universite De Nantes ,  Universite de Bourgogne ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

发明人： Jean-Michel Robert ,  Stéphanie Troy-Fioramonti ,  Laurent Demizieux ,  Pascal DeGrace

IPC分类号： C07D403/04 ,  C07D205/085 ,  A61P3/00

摘要： The present invention relates to a compound with formula (I) or a salt and/or a pharmaceutically acceptable solvate thereof, the method for preparing same as well as the uses thereof, in particular the therapeutic use thereof, mainly in the treatment of diseases associated with a hyperactivity of the endocannabinoid system.

公开(公告)号：US10436787B2

公开(公告)日：2019-10-08

申请号：US15038135

申请日：2014-11-24

申请人： Institut de Cancerologie de L'Ouest ,  Universite D'Angers ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

发明人： Catherine Guette ,  Pedro Raro ,  Olivier Coqueret ,  Benjamin Barre ,  Mario Campone

IPC分类号： G01N33/574 ,  G01N33/50

摘要： The present invention is in the technical field of breast cancer management, and more particularly relates to the diagnosis of breast cancer. The invention is more particularly based on the finding that specific biomarkers (olfactomedin-4, neudesin and desmoplakin) are abberantly expressed in the blood of breast cancer patients.

公开(公告)号：US10426758B2

公开(公告)日：2019-10-01

申请号：US15768388

申请日：2016-10-13

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite De Poitiers ,  Sorbonne Universite ,  Universite Claude Bernard Lyon 1

发明人： Marie-Thérèse Dimanche-Boitrel ,  Stéphane Bach ,  Claire Delehouze ,  Yvette Mettey ,  Peter Goekjian ,  Arnaud Comte

IPC分类号： A61K31/437 ,  C07D471/04 ,  A01N1/02 ,  A61P9/10 ,  A61P1/16 ,  A61P1/00

摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

公开(公告)号：US20190292186A1

公开(公告)日：2019-09-26

申请号：US16067471

申请日：2016-12-27

申请人： Centre national de la recherche scientifique ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  Université d'Aix-Marseille ,  Institut Jean Paoli & Irene Calmettes

发明人： Xavier MORELLI ,  Sébastien COMBES ,  Jean-Claude GUILLEMOT ,  Stéphanie BETZI ,  Yves COLLETTE ,  Philippe ROCHE ,  Adrein LUGARI ,  Sabine MILHAS ,  Brigit RAUX ,  luliia VOITOVICH

IPC分类号： C07D473/04 ,  C07D519/00 ,  A61P35/02

摘要： This invention relates to xanthine derivative compounds that are inhibitors of BET bromodomains proteins, the method of preparation thereof and applications thereof.

公开(公告)号：US10322133B2

公开(公告)日：2019-06-18

申请号：US15759815

申请日：2016-09-21

申请人： Commissariat a l'Energie Atomique et aux Energies Alternatives ,  Institut National de la Sante et de la Recherche Medicale (INSERM)

发明人： Sofia Giacosa ,  Catherine Pillet ,  Claude Cochet ,  Odile Filhol ,  Caroline Barette ,  Emmanuelle Soleilhac

IPC分类号： A61K45/06 ,  A61P35/00 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4745 ,  A61K31/5377

摘要： The present invention pertains to a novel treatment of renal cell carcinoma and other a solid tumors which harbor a VHL inactivation, based on the combination of a first agent inhibiting a protein kinase CK2 (CK2) and a second agent inhibiting an Ataxia Telangiectasia Mutated (ATM) kinase.