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公开(公告)号：US20250017205A1
公开(公告)日：2025-01-16
申请号：US18811504
申请日：2024-08-21
Applicant: Centre national de la recherche scientifique , UNIVERSITÉ D'AIX MARSEILLE , Ecole Centrale de Marseille
Inventor： Didier Gigmes , Yohann Guillaneuf , Catherine Guillaneuf , Marc René Sauveur Maresca , Cédric Ysacco
IPC: A01N37/02 , C08F293/00 , C08J7/04 , C08L53/00 , C09D5/14 , C09D153/00
Abstract: A solid organic material comprising at least one amphiphilic block copolymer of the methacrylic type, the block copolymer being dispersed in a polymer matrix, the block copolymer having a number-average molar mass (Mn) greater than or equal to 20 000 g/mol; a method for preparing said solid organic material; use of said solid organic material for antibacterial, antimicrobial, antiviral, anti-inflammatory and/or antifungal applications; a coating comprising said solid organic material.
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公开(公告)号：US20240417737A1
公开(公告)日：2024-12-19
申请号：US18289921
申请日：2022-05-16
Applicant: UNIQURE FRANCE , REGENXBIO INC. , INSERM (Institut National de la Santé et de la Recherche Médicale) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITÉ DE BORDEAUX , UNIVERSITÉ D'AIX-MARSEILLE
Inventor： Chenxia HE , Richard PORTER , Andrew MERCER , Olivier DANOS , April R. TEPE
IPC: C12N15/113 , A61P25/08 , C12N15/86
Abstract: Disclosed are methods and compositions relating to antisense therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuits.
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公开(公告)号：US12125594B2
公开(公告)日：2024-10-22
申请号：US17625204
申请日：2020-07-22
Applicant: UNIVERSITÉ D'AIX-MARSEILLE (AMU) , INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE
Inventor： Viktor Jirsa , Viktor Sip
CPC classification number: G16H50/20 , A61B6/5217 , G16H50/50
Abstract: The method for determining an onset time and an excitability of a brain region that is not observed as recruited or not recruited in a seizure activity of an epileptic patient brain includes: providing a dynamical model of a propagation of an epileptic seizure in the brain networks; providing a statistical model which defines the probability of generating sets of observations of the state of the brain networks by said dynamical model; training the dynamical model of the propagation of an epileptic seizure using the statistical model and the data set of observations of the training cohort; and inverting the trained dynamical model and inferring the onset time and excitability of a third region from the onset time that is observed for the first and second regions using the statistical model.
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公开(公告)号：US20240342826A1
公开(公告)日：2024-10-17
申请号：US18577707
申请日：2022-07-07
Inventor： David GROJO , Andong WANG , Amlan DAS
IPC: B23K26/0622 , B23K26/06 , B23K26/352 , B23K26/402 , B23K101/40
CPC classification number: B23K26/0624 , B23K26/0626 , B23K26/352 , B23K26/402 , B23K2101/40
Abstract: The invention relates to an optical writing method in a semiconductor material (10), the method comprising laser writing in volume of the semiconductor material. The method comprises, prior to laser writing, irradiating the semiconductor material (10) with at least one laser pre-pulse configured to change transiently and locally one property of the semiconductor material (10).
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公开(公告)号：US11947101B2
公开(公告)日：2024-04-02
申请号：US17278026
申请日：2019-09-10
Applicant: Centre National de la Recherche Scientifique , Université d'Aix-Marseille , Université de Lille , Ecole Centrale de Marseille
Inventor： Hervé Rigneault , Géraud Bouwmans , Esben Andresen , Siddarth Sivankutty , Viktor Tsvirkun , Olivier Vanvincq
CPC classification number: G02B23/2469 , A61B1/00167 , A61B1/00172 , G02B23/26
Abstract: According to one aspect, the invention relates to a device (200) for transporting and controlling light beams comprising a light guide (40) comprising a bundle (50) of uncoupled single-mode optical fibers (Fi), each single-mode optical fiber (Fi) being intended to receive an elementary light beam (B1i) at a proximal end and to emit a light beam (B2i) at a distal end, said bundle of single-mode optical fibers comprising, in operation, a minimum radius of curvature corresponding to a maximum curvature of the bundle of fibers. The device (200) furthermore comprises an optical device for phase controlling, said device being arranged on the side of the proximal end of the light guide (40) and comprising at least a first spatial light modulator (30) suitable for applying a phase shift to each of the elementary beams (B1i), and a control unit (60) for controlling the first spatial light modulator, said unit being configured to apply a phase shift to each of the elementary beams (B1i) so as to form, at the distal end of the light guide, an illumination beam with a predefined phase function. According to the present description, said bundle (50) of single-mode optical fibers is twisted, and comprises a twist period (P) defined to preserve said phase function at the distal end of the light guide when the bundle of single-mode optical fibers is subjected to a curvature lower than said maximum curvature.
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Patent Agency Ranking
公开(公告)号：US11945871B2
公开(公告)日：2024-04-02
申请号：US18327127
申请日：2023-06-01
Applicant: Imcheck Therapeutics SAS , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université d'Aix Marseille , Institut Jean Paoli & Irene Calmette , Centre National de la Recherche Scientifique—CNRS
Inventor： Alemseged Truneh , Daniel Olive , Christine Pasero , Aude De Gassart
CPC classification number: C07K16/2827 , A61K9/19 , A61K38/2013 , A61K38/2086 , A61K39/3955 , A61P35/00 , C07K16/2818 , A61K39/00 , A61K2039/505 , A61K2039/507 , C07K2317/56
Abstract: The present invention relates to humanized antibodies that specifically bind to human BTN3A and their use in treating cancer and infectious disorders.
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公开(公告)号：US20240018524A1
公开(公告)日：2024-01-18
申请号：US18014906
申请日：2021-07-09
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ D'AIX-MARSEILLE , UNIVERSITÉ DE BORDEAUX , REGENXBIO INC. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , Corlieve Therapeutics
Inventor： Valérie CREPEL , Christophe MULLE , Céline BOILEAU , Séverine DEFORGES , Olivier DANOS , Andrew MERCER , Richard PORTER , April R. TEPE
IPC: C12N15/113
CPC classification number: C12N15/1138 , C12N2310/14 , C12N2330/50 , C12N2320/11 , C12N2320/31
Abstract: The present disclosure provides methods and compositions relating to gene therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the present disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuit.
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8.发明公开公开(公告)号：US20230374968A1
公开(公告)日：2023-11-23
申请号：US18248593
申请日：2021-10-08
Applicant: UNIVERSITÉ D'AIX-MARSEILLE , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CENTRALE MARSEILLE , DANMARKS TEKNISKE UNIVERSITET (DTU)
Inventor： Thomas Leweke , Jens Sorensen
CPC classification number: F03D1/0633 , F03D7/049 , F05B2240/96 , F05B2270/204 , F05B2240/307
Abstract: A wind farm/park having a plurality of spatially distributed wind turbines, including at least one upstream wind turbine and at least one downstream wind turbine. Each wind turbine includes a rotor with at least two blades. At least one downstream wind turbine is affected under certain wind conditions by a wake region generated by the upstream wind turbine and containing helical vortex structures formed at the tip of the blades of the upstream wind turbine. A geometry or configuration of one or more of the rotor blades of the upstream wind turbine is different from a geometry or configuration of the other blade(s) of the upstream wind turbine thereby creating a fixed asymmetry in the blade configuration so as to accelerate destruction of vortices in the wake of the rotor of the upstream wind turbine by exciting a natural instability of the blade tip vortices.
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公开(公告)号：US20230372078A1
公开(公告)日：2023-11-23
申请号：US18247969
申请日：2020-10-06
Applicant: UNIVERSITÉ D'AIX-MARSEILLE , ASSISTANCE PUBLIQUE - HÔPITAUX DE MARSEILLE , Université Gustave Eiffel
Inventor： Yves Alimi
CPC classification number: A61F2/07 , A61F2/962 , A61F2/064 , A61F2002/9623
Abstract: A percutaneous bypass method for implanting a bypass graft between two vessels is described. The bypass graft comprises a first part and a second part, each having a tubular shape and comprising respective lumens. The method comprises the step of inserting a second sheath, from the outside to the inside of a bypass portion of the first part, through a puncture therein, and retracting the second sheath so as to deploy and implant a hook portion of the second part into the second vessel, and deploy a bypass portion of the second part outside the second vessel, from the second vessel to the first part, and within the lumen of the first part.
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公开(公告)号：US20230227829A1
公开(公告)日：2023-07-20
申请号：US18154241
申请日：2023-01-13
Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ D'AIX-MARSEILLE , UNIVERSITÉ DE BORDEAUX , REGENXBIO INC. , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , CORLIEVE THERAPEUTICS
Inventor： Valérie CREPEL , Christophe MULLE , Céline BOILEAU , Séverine DEFORGES , Olivier DANOS , Andrew MERCER , Richard PORTER , April R. TEPE
IPC: C12N15/113 , C12N15/86 , A61P25/08
CPC classification number: C12N15/113 , C12N15/86 , A61P25/08 , C12N2310/11 , C12N2750/14143
Abstract: The present disclosure provides methods and compositions relating to gene therapy for treating epilepsy, such as a temporal lobe epilepsy, in a subject in need thereof by targeting Grik2 mRNA. In particular, the present disclosure provides inhibitory RNA constructs capable of inhibiting expression of GluK2 protein and inhibiting epileptiform discharges in hyperexcitable neuronal circuit.
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