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公开(公告)号：US11208474B2
公开(公告)日：2021-12-28
申请号：US15813767
申请日：2017-11-15
发明人： Dennis Fitzgerald , Newman Yeilding , Jay Siegel
IPC分类号： A61K39/395 , C07K16/24 , A61K9/00 , G01N33/00 , A61P17/06 , A61K31/519 , A61K45/06 , C07K16/28 , A61K47/22 , A61K47/26 , A61K39/00
摘要： A method of treating psoriasis in a patient previously treated with and determined to be an inadequate responder to an IL-12/23p40 antibody by administering an IL-23 specific antibody, e.g., guselkumab, in a safe and effective amount and the patient achieves PASI75, PASI90, PASI100 or IGA 0 or 1 score as measured 16, 24, 32, 40 and 48 weeks after initial treatment.
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72.发明授权公开(公告)号：US11197913B2
公开(公告)日：2021-12-14
申请号：US16993556
申请日：2020-08-14
发明人： Marc Chevrier , Kamyar Farahi , Newman Yeilding
IPC分类号： A61K39/395 , C07K16/24 , A61K38/20 , A01K67/027 , A61K39/00 , C07K14/54 , A61K35/12
摘要： A method of treating an IL-12/23-related disease in a patient using an increasing dosing interval, comprises increasing the dosing interval of IL-12/IL-23 antibody to a patient, wherein the antibody is administered initially and after 4 weeks, after 16 weeks and after 28 weeks, and increasing the dosing interval after 28 weeks to an increased interval, e.g., every 16, 20 or 24 weeks.
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公开(公告)号：US11180549B2
公开(公告)日：2021-11-23
申请号：US16717594
申请日：2019-12-17
发明人： Yan Chen , Debra Gardner , David M. Knight , Michael W. Lark , Bailin Liang , David M. Marquis , David J. Shealy , Eric Michael Smith , Xiao-yu R. Song , Vedrana Stojanovic-Susulic , Raymond Sweet , Susan Tam , Alain P. Vasserot , Sheng-Jiun Wu , Jing Yang
摘要： Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.
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公开(公告)号：US20210322323A1
公开(公告)日：2021-10-21
申请号：US17228753
申请日：2021-04-13
发明人： Jacqueline Maximilien , Gopal Rajan
IPC分类号： A61K9/28 , A61K9/20 , A61K31/5377 , A61K9/00
摘要： Provided herein are pharmaceutical compositions for oral administration comprising N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pirimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide or a pharmaceutically acceptable salt, hydrate, or solvate thereof as an active ingredient; and a combination of (i) a cellulose derivative and (ii) a sugar or polyol as diluents. The disclosed compositions are characterized by improved manufacturability, while maintaining the pharmaceutical benefits of minimizing the effect according to changes in pH environment in the stomach, possessing excellent stability, and exhibiting good bioavailability.
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公开(公告)号：US11124565B2
公开(公告)日：2021-09-21
申请号：US16540388
申请日：2019-08-14
发明人： Joseph Hedrick , Elizabeth C. Hsia , Paul Imm , Jocelyn Leu , Bethany Paxson , Mark Rigby , Songmao Zheng , Ramineh Zoka
摘要： The present invention relates to compositions and methods utilizing anti-TNF antibodies having a heavy chain (HC) comprising SEQ ID NO:36 and a light chain (LC) comprising SEQ ID NO:37 for use in the treatment or prevention of Type I Diabetes (T1D).
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公开(公告)号：US20210284731A1
公开(公告)日：2021-09-16
申请号：US17202004
申请日：2021-03-15
发明人： Rajkumar Ganesan , Iqbal S. Grewal , Sanjaya Singh
摘要： Anti-TRGV9 molecules, such as anti-TRGV9 antibodies or antigen binding fragments thereof, are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20210261636A1
公开(公告)日：2021-08-26
申请号：US17174590
申请日：2021-02-12
发明人： Vipul BHARGAVA , Vinod Krishna , Jaymala Patel , David J. Pocalyko , Yashoda Rani Rajpurohit , Pegah Safabakhsh , Manuel Alejandro Sepulveda
摘要： The disclosure relates to multiple myeloma neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the multiple myeloma neoantigens, and methods of making and using them.
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公开(公告)号：US20210261609A1
公开(公告)日：2021-08-26
申请号：US17174505
申请日：2021-02-12
发明人： Vipul BHARGAVA , Vinod Krishna , David J. Pocalyko , Pegah Safabakhsh , Manuel Alejandro Sepulveda
摘要： The disclosure relates to ovarian cancer neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the ovarian cancer neoantigens, and methods of making and using them.
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公开(公告)号：US20210253717A1
公开(公告)日：2021-08-19
申请号：US17174386
申请日：2021-02-12
发明人： Roland Knoblauch , Sylvie Laquerre , Sheri Moores
摘要： The present invention relates to treatment of subjects having a cancer that is positive for c-Met exon 14 skipping mutations.
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公开(公告)号：US20210206825A1
公开(公告)日：2021-07-08
申请号：US17174524
申请日：2021-02-12
发明人： Mark Anderson , Ricardo Attar , Michael Diem , Linus Hyun , Steven Jacobs , Alastair King , Donna Klein , Sheri Moores , Karyn O'Neil , Kristen Picha
IPC分类号： C07K14/705 , C07K14/78 , C07K14/71 , C07K16/28 , C07K14/47
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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