公开(公告)号：US20100268048A1

公开(公告)日：2010-10-21

申请号：US12825681

申请日：2010-06-29

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100268044A1

公开(公告)日：2010-10-21

申请号：US12825180

申请日：2010-06-28

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100240974A1

公开(公告)日：2010-09-23

申请号：US12793665

申请日：2010-06-03

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100223021A1

公开(公告)日：2010-09-02

申请号：US12779941

申请日：2010-05-13

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20100204554A1

公开(公告)日：2010-08-12

申请号：US12761381

申请日：2010-04-15

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke

IPC分类号： A61B5/1468

CPC分类号： A61B5/14532 ,  A61B5/01 ,  A61B5/14542 ,  A61B5/14546 ,  A61B5/14735 ,  A61B5/1486 ,  A61B5/14865 ,  C12Q1/001 ,  C12Q1/006

摘要： An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid.

公开(公告)号：US20100012512A1

公开(公告)日：2010-01-21

申请号：US12568845

申请日：2009-09-29

申请人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

发明人： Adam Heller ,  Benjamin J. Feldman ,  James Say ,  Mark S. Vreeke

IPC分类号： C12Q1/54 ,  G01N27/30

CPC分类号： G01N27/3272 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/150022 ,  A61B5/150358 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15105 ,  A61B5/15113 ,  A61B5/15144 ,  A61B5/157 ,  A61B2560/0223 ,  A61B2562/0295 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N33/5438 ,  G01N2333/904

摘要： A sensor designed to determine the amount and concentration of analyte in a sample having a volume of less than about 1 μL. The sensor has a working electrode coated with a non-leachable redox mediator. The redox mediator acts as an electron transfer agent between the analyte and the electrode. In addition, a second electron transfer agent, such as an enzyme, can be added to facilitate the electrooxidation or electroreduction of the analyte. The redox mediator is typically a redox compound bound to a polymer. The preferred redox mediators are air-oxidizable.The amount of analyte can be determined by coulometry. One particular coulometric technique includes the measurement of the current between the working electrode and a counter or reference electrode at two or more times. The charge passed by this current to or from the analyte is correlated with the amount of analyte in the sample. Other electrochemical detection methods, such as amperometric, voltammetric, and potentiometric techniques, can also be used.The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is provided as a second electron transfer agent.

公开(公告)号：US20090192378A1

公开(公告)日：2009-07-30

申请号：US12418462

申请日：2009-04-03

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090192370A1

公开(公告)日：2009-07-30

申请号：US12414542

申请日：2009-03-30

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090187091A1

公开(公告)日：2009-07-23

申请号：US12414511

申请日：2009-03-30

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Heller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

公开(公告)号：US20090187088A1

公开(公告)日：2009-07-23

申请号：US12406746

申请日：2009-03-18

申请人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Hiller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

发明人： James Say ,  Michael F. Tomasco ,  Adam Heller ,  Yoram Gal ,  Behrad Aria ,  Ephraim Hiller ,  Phillip John Plante ,  Mark S. Vreeke ,  Keith A. Friedman ,  Fredric C. Colman

IPC分类号： A61B5/1468

CPC分类号： A61B5/14865 ,  A61B5/0002 ,  A61B5/002 ,  A61B5/01 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/4839 ,  A61B5/72 ,  A61B5/7278 ,  A61B5/7282 ,  A61B5/7405 ,  A61B5/743 ,  A61B5/7445 ,  A61B5/7455 ,  A61B2560/0252 ,  A61M5/1723 ,  C12Q1/54 ,  G06F19/00 ,  G06F19/34 ,  H01L23/3107 ,  H01L23/49548 ,  H01L2924/0002 ,  H01L2924/19041 ,  H01L2924/3011 ,  Y10S128/903 ,  Y10T29/49 ,  Y10T29/49124 ,  H01L2924/00

摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.