Sesquiterpenoid derivative and use thereof in preparing broad-spectrum antiviral drug

    公开(公告)号:US12258351B2

    公开(公告)日:2025-03-25

    申请号:US18625188

    申请日:2024-04-02

    Inventor: Min Xu Shaoxing Dai

    Abstract: A sesquiterpenoid derivative and use thereof in preparing a broad-spectrum antiviral drug provided. The sesquiterpenoid derivative can stimulate heterogeneous nuclear ribonucleoprotein A2/B1, activate the cell signal pathway of TANK-binding kinase 1-interferon regulatory factor 3, and increase the expression and secretion of endogenous type I interferon. As a result, it can inhibiting various viruses and can be used as a broad-spectrum antiviral drug for preventing or treating various viral infectious diseases and symptoms, including Covid-19, vesicular stomatitis virus VSV-G, AIDS virus, hepatitis C virus, Japanese encephalitis virus, influenza virus, poliovirus, Coxsackie virus, dengue virus, rotavirus, tobacco mosaic virus, measles virus, mumps virus, Ebola virus, Marburg virus, herpes virus and adenovirus. Sesquiterpenoid derivatives can be made as a raw material into oral dosage form such as tablet, capsule and dripping pill, or clinically acceptable pharmaceutical preparation such as inhalant and injection.

    METHOD FOR DESIGNING SUPERCRITICAL HEAT EXCHANGER BASED ON PSEUDO-PHASE TRANSITION PARTITION

    公开(公告)号:US20250086365A1

    公开(公告)日:2025-03-13

    申请号:US18955880

    申请日:2024-11-21

    Abstract: The present disclosure provides a method for designing a supercritical heat exchanger based on pseudo-phase transition partition. The method mainly includes the following steps: inputting boundary conditions of a heat exchanger; calculating an upper boundary temperature and a lower boundary temperature of a pseudo-phase transition region; calculating a temperature of an inner wall surface of a supercritical fluid; determining an upper boundary temperature of a pseudo-superheated condensation region; and dividing the heat exchanger into four sections on the basis of above three boundary temperatures and inlet and outlet temperatures, and calculating the section size and the total size of the heat exchanger. According to the method, the automatic partition determination of single-phase cooling and pseudo-superheated condensation in a supercritical air cooler can be realized, requiring no division of the heat exchanger according to equal enthalpy change or equal length, and the calculation is rapid and accurate.

    Method for preparing heteroatom-doped CNHS

    公开(公告)号:US11981569B2

    公开(公告)日:2024-05-14

    申请号:US18304316

    申请日:2023-04-20

    CPC classification number: C01B32/18 B01J21/18 B01J23/42 B01J35/23 B01J37/08

    Abstract: A method includes the following steps: a first step: the material containing heteroatom and graphite powder are mixed for a preset time by grinding, and the molar ratio of heteroatom to carbon atom is 1%-10%, then the heteroatom precursors are obtained; a second contact step: the heteroatom precursor is filled into a graphite rod with holes and compacted, then the graphite rod is dried for a preset time to obtain a plasma anode and using a DC arc plasma device to prepare the graphite anode into heteroatom-doped CNHs; a third contact step: the heteroatom-doped CNHs are dispersed in a reducing solution, a platinum salt is added to stir evenly, the reduction reaction is carried out by heating and stirring, and after centrifugation, washing and drying, a catalyst with platinum loading is obtained.

    METHOD FOR PREPARING METALLIC TITANIUM USING TITANIUM-CONTAINING OXIDE SLAG

    公开(公告)号:US20240124998A1

    公开(公告)日:2024-04-18

    申请号:US18397411

    申请日:2023-12-27

    CPC classification number: C25C3/28 C22B34/1277 C22B34/1295

    Abstract: The titanium-containing oxide slag, low-purity silicon and slagging fluxes are subject to reduction smelting together, and a bulk Si—Ti intermediate alloy is obtained by slag-metal separation; the obtained bulk Si—Ti intermediate alloy is crushed into Si—Ti intermediate alloy particles; and the obtained Si—Ti intermediate alloy particles are used as an anode, metallic molybdenum or metallic nickel as a cathode, metallic titanium as a reference electrode, and NaCl—KCl—NaF together with small amounts of Na3TiF6 or K3TiF6 as a molten salt, to carry out the electrolysis under a high-purity argon atmosphere at a temperature of 973 K. Ti in the Si—Ti intermediate alloy particles dissolved at the anode and deposited at the cathode, while Si in the Si—Ti intermediate alloy particles fell off from the anode as metallic silicon powder.

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