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    Use of c-Fms antagonists
    72.
    发明申请
    Use of c-Fms antagonists 有权
    使用c-Fms拮抗剂

    公开(公告)号：US20160185867A1

    公开(公告)日：2016-06-30

    申请号：US14970578

    申请日：2015-12-16

    Applicant: MorphoSys AG ,  The University of Melbourne

    Inventor： Stefan Steidl ,  John Allan Hamilton ,  Andrew David Cook

    IPC: C07K16/28 ,  C07K16/24

    CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/243 ,  C07K16/244 ,  C07K16/249 ,  C07K2317/76

    Abstract: The present invention relates generally to a method for the treatment and/or prophylaxis of osteoarthritis (OA) and/or pain. In accordance with the present invention, an antagonist of c-Fms is effective in the treatment of osteoarthritis and/or pain. An antagonist of M-CSF includes, but is not limited to, an antibody that is specific for M-CSF, IL-34 or c-Fms.

    Abstract translation: 本发明一般涉及治疗和/或预防骨关节炎（OA）和/或疼痛的方法。 根据本发明，c-Fms的拮抗剂对于治疗骨关节炎和/或疼痛是有效的。 M-CSF的拮抗剂包括但不限于对M-CSF，IL-34或c-Fms特异性的抗体。

    Use of lysozyme as a tag
    74.
    发明申请
    Use of lysozyme as a tag 有权
    使用溶菌酶作为标签

    公开(公告)号：US20140349343A1

    公开(公告)日：2014-11-27

    申请号：US14368513

    申请日：2013-01-23

    Applicant: MorphoSys AG

    Inventor： Stefan Haertle ,  Sebastian Jaeger ,  Daniela Daubert

    IPC: C12P21/00

    CPC classification number: C12P21/00 ,  C07K1/22 ,  C07K2319/00 ,  C07K2319/35 ,  C12N15/62 ,  C12P21/02

    Abstract: The present disclosure provides a method to express and purify polypeptides and proteins. In the present disclosure the use of lysozyme as a fusion partner is disclosed. Furthermore, purification methods to isolate lysozyme-tagged polypeptides and proteins via lysozyme-specific antibodies are described. More specifically, the present disclosure provides a method to express and purify monomeric polypeptides and proteins by using lysozyme as a tag.

    Abstract translation: 本公开提供了表达和纯化多肽和蛋白质的方法。 在本公开中公开了溶菌酶作为融合配偶体的用途。 此外，描述了通过溶菌酶特异性抗体分离溶菌酶标记的多肽和蛋白质的纯化方法。 更具体地，本公开提供了通过使用溶菌酶作为标签来表达和纯化单体多肽和蛋白质的方法。

    COMBINATIONS OF ANTIGEN BINDING MOLECULES
    75.
    发明申请
    COMBINATIONS OF ANTIGEN BINDING MOLECULES 有权

    公开(公告)号：US20250101103A1

    公开(公告)日：2025-03-27

    申请号：US18291283

    申请日：2022-07-27

    Applicant: MORPHOSYS AG

    Inventor： Markus MOOSMEIER ,  Nicole HAUBST ,  Yvonne STARK

    IPC: C07K16/28 ,  C07K16/32

    Abstract: The present disclosure provides combinations or sets of two antigen binding molecule, in particular asymmetric combinations of such antigen binding molecules. Each of the two antigen binding molecules is composed of a targeting moiety with specificity for a tumor associated antigen fused to either the VL or VH domain of an antibody Fv domain specific for CD3. Once the two antigen binding molecules bind to their target antigen on the surface of a cell, the complementary VL and VH domain are capable to associate with each other thereby reconstituting the functional CD3 specific Fv domain and non-covalently dimerizing the two antigen binding molecules. The thus on-cell formed trispecific heterodimeric antibody molecule is capable of engaging and stimulating cytotoxic T-cells for tumor cell destruction.

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