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公开(公告)号：US20160060347A1
公开(公告)日：2016-03-03
申请号：US14781923
申请日：2014-04-15
Applicant: MORPHOSYS AG
Inventor： Tanja Herrmann , Andreas Bueltmann
IPC: C07K16/28
CPC classification number: C07K16/2866 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/92 , C07K2319/00
Abstract: This disclosure generally relates to antibodies or fragments thereof which interact with CXCR2. The disclosure further discloses antibodies, which bind to specific extracellular domains of CXCR2. The disclosure further relates to therapeutics comprising CXCR2-specific antibodies and methods of treatment using CXCR2-specific antibodies or fragments thereof.
Abstract translation: 本公开通常涉及与CXCR2相互作用的抗体或其片段。 本公开进一步公开了结合CXCR2的特异性细胞外结构域的抗体。 本公开还涉及包含CXCR2特异性抗体的治疗剂和使用CXCR2特异性抗体或其片段的治疗方法。
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公开(公告)号：US10647757B2
公开(公告)日：2020-05-12
申请号：US15449561
申请日：2017-03-03
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
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公开(公告)号：US12018072B2
公开(公告)日：2024-06-25
申请号：US18456323
申请日：2023-08-25
Applicant: MORPHOSYS AG
Inventor： Julia Neugebauer , Barbara Bachler-Konetzki , Tanja Herrmann , Winfried Elis
CPC classification number: C07K16/18 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/33 , C07K2317/35 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92
Abstract: The present invention provides novel antibodies or antibody fragments specifically binding to human C5aR. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment of inflammatory or autoimmune diseases or cancer.
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Patent Agency Ranking
公开(公告)号：US20240018225A1
公开(公告)日：2024-01-18
申请号：US18456323
申请日：2023-08-25
Applicant: MORPHOSYS AG
Inventor： Julia Neugebauer , Barbara Bachler-Konetzki , Tanja Herrmann , Winfried Elis
IPC: C07K16/28
CPC classification number: C07K16/2896 , A61K2039/505
Abstract: The present invention provides novel antibodies or antibody fragments specifically binding to human C5aR. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment of inflammatory or autoimmune diseases or cancer.
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公开(公告)号：US09624293B2
公开(公告)日：2017-04-18
申请号：US14169162
申请日：2014-01-31
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
CPC classification number: C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
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公开(公告)号：US20240400657A1
公开(公告)日：2024-12-05
申请号：US18658860
申请日：2024-05-08
Applicant: MORPHOSYS AG
Inventor： Julia Neugebauer , Barbara Bachler-Konetzki , Tanja Herrmann , Winfried Elis
Abstract: The present invention provides novel antibodies or antibody fragments specifically binding to human C5aR. In particular, it relates to antibodies or antibody fragments that have combined beneficial properties and are therefore useful for the treatment of inflammatory or autoimmune diseases or cancer.
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公开(公告)号：US20170218048A1
公开(公告)日：2017-08-03
申请号：US15449561
申请日：2017-03-03
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
CPC classification number: C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
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公开(公告)号：US20140163208A1
公开(公告)日：2014-06-12
申请号：US14169162
申请日：2014-01-31
Applicant: MorphoSys AG
Inventor： Markus Enzelberger , Stefanie Urlinger , Thomas Tiller , Josef Prassler , Tanja Herrmann
IPC: C07K16/00
CPC classification number: C07K16/005 , C07K16/00 , C07K16/32 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C12N15/1093 , C40B30/04 , C40B40/08 , C40B50/06
Abstract: The present disclosure enables methods of identifying the VH and VL class pairs in the human immune repertoire, determining the VH and VL class pairs that are most prevalent and those having favorable biophysical properties. More specifically, the collections of the present disclosure comprise the most prevalent and/or preferred VH and VL class pairings with highly diversified CDRs.
Abstract translation: 本公开使得能够鉴定人免疫谱中的VH和VL类对的方法，确定最普遍的VH和VL类对以及具有有利的生物物理性质的那些。 更具体地，本公开的集合包含具有高度多样化的CDR的最普遍和/或优选的VH和VL类配对。
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