公开(公告)号：US20020142430A1

公开(公告)日：2002-10-03

申请号：US10153921

申请日：2002-05-24

申请人： PE CORPORATION (NY)

发明人： Chunhua Yan ,  Ming-Hui Wei ,  Karen Ketchum ,  Gennady Merkulov ,  Ellen M. Beasley

IPC分类号： C12N009/12 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

公开(公告)号：US20020132325A1

公开(公告)日：2002-09-19

申请号：US10096960

申请日：2002-03-14

申请人： PE CORPORATION (NY)

发明人： Jane Ye ,  Chunhua Yan ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC分类号： C12N009/12 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C12N9/1205

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

公开(公告)号：US20020132324A1

公开(公告)日：2002-09-19

申请号：US10060332

申请日：2002-02-01

申请人： PE CORPORATION (NY)

发明人： Jiayin Li ,  Karl Guegler ,  Ellen M. Beasley ,  Karen A. Ketchum ,  Valentina Di Francesco

IPC分类号： C12N009/12 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C12N9/1205 ,  A01K2217/05 ,  A61K38/00 ,  C12Y207/11013

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.

公开(公告)号：US20020127644A1

公开(公告)日：2002-09-12

申请号：US09949654

申请日：2001-09-12

申请人： PE CORPORATION (NY)

发明人： Chunhua Yan ,  Jane Ye ,  Ming-Hui Wei ,  Karen A. Ketchum ,  Valentina Difrancesco ,  Ellen M. Beasley

IPC分类号： C12P021/02 ,  C12N005/06 ,  C07K014/435 ,  C07H021/04

CPC分类号： C07K14/70571

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

公开(公告)号：US20020115186A1

公开(公告)日：2002-08-22

申请号：US10060333

申请日：2002-02-01

申请人： PE CORPORATION (NY)

发明人： Marion Webster ,  Karen A. Ketchum ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC分类号： C12N009/64 ,  C12N009/50 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C12N9/6424

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.

公开(公告)号：US20020115179A1

公开(公告)日：2002-08-22

申请号：US10094989

申请日：2002-03-12

申请人： PE CORPORATION (NY)

发明人： Ming-Hui Wei ,  Xin Wang ,  Gennady V. Merkulov ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC分类号： C12N009/18 ,  C07H021/04 ,  C12P021/02 ,  C12N005/06

CPC分类号： C12N9/16

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.

摘要翻译： 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的磷酸二酯酶。 本发明具体提供分离的肽和核酸分子，鉴定磷酸二酯酶多肽的直系同源物和旁系同源物的方法，以及鉴定磷酸二酯酶多肽调节剂的方法。

公开(公告)号：US20020034778A1

公开(公告)日：2002-03-21

申请号：US09781558

申请日：2001-02-13

申请人： PE CORPORATION (NY)

发明人： Rhonda C. Brandon ,  Karen A. Ketchum ,  Valentina Di Francesco ,  Ellen M. Beasley

IPC分类号： C12Q001/68 ,  G01N033/53 ,  A01K067/00 ,  C07H021/04 ,  C12N009/00 ,  C12P021/02 ,  C12N005/06

CPC分类号： C07K14/705

摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.

公开(公告)号：US20010018216A1

公开(公告)日：2001-08-30

申请号：US09846467

申请日：2001-04-30

申请人： PE Corporation (NY)

发明人： Reid B. Kowallis

IPC分类号： G01N021/00

CPC分类号： B01L3/0244 ,  B01J2219/00367 ,  B01J2219/00459 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00605 ,  B01J2219/00648 ,  B01J2219/00659 ,  B01L3/0262 ,  B01L2300/0838 ,  C40B60/14 ,  G01N35/00009 ,  G01N35/10 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/112499 ,  Y10T436/114998 ,  Y10T436/25 ,  Y10T436/25625 ,  Y10T436/2575

摘要： The present invention provides a method and apparatus for dispensing small volumes of selected substances, such as biological reagents or samples, onto substrates. According to one general embodiment, a plurality of spaced, tandemly-arranged substrates are advanced, e.g., by way of a conveyor, along a transport pathway extending over a reagent-supply location, such as a reservoir supported at a fixed position in a base. From a position over the reagent-supply location and the pathway, a reagent-transfer instrument, or tip, is extended along an axis through an intervening region, e.g., an opening defined by a surface of the conveyor, separating an adjacent pair of advancing substrates to contact reagent held at the reagent-supply location. The reagent-transfer instrument is then withdrawn, along with a portion of such reagent, through the intervening region to a position above the transport pathway. Once the conveyor has advanced a selected substrate, upstream of the intervening region, to a position aligned with the axis of the reagent-transfer instrument, a selected amount of reagent is transferred from the instrument onto a selected site of the substrate. Advantageously, the apparatus and method are readily adaptable for the production of micro-arrays having a great number of closely spaced spots.

摘要翻译： 本发明提供了用于将小体积的选定物质（例如生物试剂或样品）分配到基底上的方法和装置。 根据一个一般实施例，沿着沿着试剂供应位置延伸的输送路径，例如通过输送机前进的多个间隔开的串列布置的基板，例如支撑在基座中的固定位置处的储存器 。 从试剂供应位置和路径上的位置，试剂转移仪器或尖端沿着轴线延伸穿过中间区域，例如由输送机的表面限定的开口，分离相邻的一对前进 接触试剂供应位置的接触试剂的底物。 然后将试剂转移仪器连同一部分这种试剂一起通过中间区域排出到输送通道上方的位置。 一旦输送机将所选择的基板在中间区域的上游推进到与试剂转移仪器的轴线对准的位置，则将选定量的试剂从仪器转移到基板的选定位置。 有利地，该装置和方法容易适用于生产具有大量紧密间隔的点的微阵列。