公开(公告)号：US20250064933A1

公开(公告)日：2025-02-27

申请号：US18724820

申请日：2022-12-29

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Stephen GOTTSCHALK ,  Peter CHOCKLEY

IPC: A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30

Abstract: The present application provides chimeric antigen receptors (CARs) comprising an anchoring domain, such as a PDZ binding motif, which binds to a cell polarity protein. Also provided are poly nucleotides encoding the CARs, vectors, and cell compositions comprising the same. Pharmaceutical compositions comprising the polypeptides, polynucleotides, vectors, or cells of the present disclosure, and their uses in treating a disease in a subject are also provided.

公开(公告)号：US20240344145A1

公开(公告)日：2024-10-17

申请号：US18683969

申请日：2022-08-15

Applicant: University of Florida Research Foundation, Incorporated ,  St. Jude Children's Research Hospital, Inc. ,  University of Tennessee Research Foundation

Inventor： Jatinder Kaur Lamba ,  Abdelrahman H. Elsayed ,  Xueyuan Cao ,  Stanley Pounds

IPC: C12Q1/6886 ,  C12Q1/6874

CPC classification number: C12Q1/6886 ,  C12Q1/6874 ,  C12Q2600/106 ,  C12Q2600/156

Abstract: The disclosure relates to methods for characterizing and/or treating a subject having cancer, said methods comprising performing an assay to identify the nucleotides present at each of a set of single-nucleotide polymorphism (SNP) locations within the cytarabine (ara-C) pathway, assigning a genotype score for the identified nucleotides of each SNP, and characterizing the subject having cancer based on the summation of the assigned genotype scores. In some embodiments, treatment is administered based upon the characterization of the subject, according to the methods described herein.

公开(公告)号：US20240191196A1

公开(公告)日：2024-06-13

申请号：US18511513

申请日：2023-11-16

Applicant: St. Jude Children's Research Hospital, Inc. ,  National University of Singapore

Inventor： Dario CAMPANA ,  Yu-Hsiang CHANG

IPC: C12N5/0783 ,  A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C12N5/00

CPC classification number: C12N5/0646 ,  A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/7051 ,  C07K14/7056 ,  C12N5/0087 ,  C07K2319/00 ,  C07K2319/70 ,  C12N2510/00

Abstract: The invention provides a chimeric receptor comprising NKG2D, DAP10 and CD3 zeta. Also disclosed is a composition comprising this chimeric receptor and methods for making and using it to enhance the cytotoxicity and antitumor capacity of NK cells. The invention also encompasses methods for use of NKG2D-DAP10-CD3 zeta polypeptides, vectors and cells in methods for treating cancer and other proliferative disorders, as well as infectious diseases.

公开(公告)号：US20240092862A1

公开(公告)日：2024-03-21

申请号：US18311318

申请日：2023-05-03

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Dario Campana ,  Chihaya Imai

IPC: C07K14/705 ,  A61K39/395 ,  C07K14/47 ,  C07K14/725 ,  C07K16/28 ,  C12N5/0783

CPC classification number: C07K14/70578 ,  A61K39/395 ,  C07K14/47 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/2896 ,  C12N5/0646 ,  C07K2319/32 ,  C12N2501/23 ,  C12N2502/11 ,  C12N2502/99

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

公开(公告)号：US11905553B2

公开(公告)日：2024-02-20

申请号：US16965796

申请日：2019-01-28

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Charles Gawad ,  John Easton ,  Veronica Gonzalez-Pena

IPC: C12Q1/686 ,  C12N15/10 ,  C12Q1/6869 ,  C12Q1/6883

CPC classification number: C12Q1/686 ,  C12N15/1093 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: Provided herein are compositions and methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for research, diagnostics, and treatment.

公开(公告)号：US20230312671A1

公开(公告)日：2023-10-05

申请号：US17919728

申请日：2021-04-23

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Mireya Paulina VELASQUEZ ,  Stephen GOTTSCHALK ,  Nikhil HEBBAR ,  Rebecca EPPERLY ,  Abishek VAIDYA

IPC: C07K14/725 ,  A61P35/00 ,  C12N15/63

CPC classification number: C07K14/7051 ,  A61P35/00 ,  C12N15/63 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present invention provides a chimeric antigen receptor (CAR) comprising an extracellular target-binding domain comprising at least one glucose-regulated-protein 78 (GRP78)-binding moiety. The present invention further provides polynucleotides and recombinant vectors encoding such CARs. The present invention further provides isolated host cells and methods for preparing isolated host cells expressing the CARs. The present invention further provides pharmaceutical compositions comprising the host cells and methods for treating a tumor using the pharmaceutical compositions.

公开(公告)号：US20230266304A1

公开(公告)日：2023-08-24

申请号：US18005105

申请日：2021-07-12

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Stacey SCHULTZ-CHERRY ,  Victoria MELIOPOULOS ,  Rebekah HONCE

IPC: G01N33/50

CPC classification number: G01N33/5088 ,  G01N2333/11 ,  G01N2333/165 ,  G01N2800/52 ,  G01N2333/46

Abstract: A method for establishing an obese ferret model by feeding a ferret with a diet having at least 25% of carbohydrate content for a period of time to provide the obese ferret model is disclosed as is a method of using said model to screen a substance for treating a respiratory infection.

公开(公告)号：US20230241180A1

公开(公告)日：2023-08-03

申请号：US17817261

申请日：2022-08-03

Applicant: UCL BUSINESS LTD ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL

Inventor： Amit Nathwani ,  Jenny McIntosh ,  Edward Tuddenham ,  Andrew Davidoff

IPC: A61K38/37 ,  C07K14/755 ,  A01K67/027

CPC classification number: A61K38/37 ,  C07K14/755 ,  A01K67/0275 ,  A01K2227/105 ,  A01K2267/01 ,  A61K48/00

Abstract: There is provided a nucleic acid molecule comprising a nucleotide sequence encoding for a functional factor VIII protein, wherein the portion of the nucleotide sequence encoding for the B domain of the factor VIII protein is between 90 and 111 nucleotides in length and encodes for an amino acid sequence comprising a sequence having at least 85% identity to SEQ ID NO: 4 and which comprises six asparagine residues. Also provided is a functional factor VIII protein, a vector comprising the above nucleic acid molecule, a host cell, a transgenic animal, a method of treating haemophilia, e.g. haemophilia A, and a method for the preparation of a parvoviral gene delivery vector.

公开(公告)号：US11673937B2

公开(公告)日：2023-06-13

申请号：US15802968

申请日：2017-11-03

Applicant: St. Jude Children's Research Hospital, Inc.

Inventor： Dario Campana ,  Chihaya Imai

IPC: C07K14/705 ,  C07K16/28 ,  C12N5/0783 ,  A61K39/395 ,  C07K14/47 ,  C07K14/725

CPC classification number: C07K14/70578 ,  A61K39/395 ,  C07K14/47 ,  C07K14/7051 ,  C07K14/70517 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/2896 ,  C12N5/0646 ,  C07K2319/32 ,  C12N2501/23 ,  C12N2502/11 ,  C12N2502/99

Abstract: The present invention relates to a chimeric receptor capable of signaling both a primary and a co-stimulatory pathway, thus allowing activation of the co-stimulatory pathway without binding to the natural ligand. The cytoplasmic domain of the receptor contains a portion of the 4-1BB signaling domain. Embodiments of the invention relate to polynucleotides that encode the receptor, vectors and host cells encoding a chimeric receptor, particularly including T cells and natural killer (NK) cells and methods of use.

公开(公告)号：US11643682B2

公开(公告)日：2023-05-09

申请号：US17900619

申请日：2022-08-31

Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.

Inventor： Charles Gawad ,  John Easton ,  Veronica Gonzalez-Pena

IPC: C12Q1/686 ,  C12N15/10 ,  C12Q1/6869 ,  C12Q1/6883

CPC classification number: C12Q1/686 ,  C12N15/1093 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: Provided herein are compositions and methods for accurate and scalable Primary Template-Directed Amplification (PTA) nucleic acid amplification and sequencing methods, and their applications for research, diagnostics, and treatment.