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71.发明授权公开(公告)号：US11612877B2
公开(公告)日：2023-03-28
申请号：US16769264
申请日：2018-12-04
申请人： Stichting voor de Technische Wetenschappen , Universiteit Utrecht Holding B.V. , UMC Utrecht Holding B.V.
发明人： Robert Smakman , Wilhelmus Everhardus Hennink , Karin Gerarda Frederika Gerritsen , Jacobus Adrianus Wilhelmus Jong , Cornelus Franciscus van Nostrum
IPC分类号： B01J20/26 , C08F8/06 , C08F8/20 , B01J20/28 , B01J20/34 , C08F212/32 , C08F212/14
摘要： The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.
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公开(公告)号：US11585878B2
公开(公告)日：2023-02-21
申请号：US17369610
申请日：2021-07-07
发明人： Carel Costijn Van Leeuwen , Alexander Jan Eberhard Raaijmakers , Bart Romke Steensma , Martino Borgo , Catalina Sofia Arteaga De Castro , Cornelius Antonius Theodorus Van Den Berg , Dennis Wilhelmus Johannes Klomp
摘要： An MRI system RF transmit antenna arrangement 3 including an antenna 5 including a length of coaxial cable 51 with an electrically conductive core 52 and an electrically conductive outer shield 53 through which the core runs, with the core having a feed point 52a arranged for electrical connection to an RF source and at least one break 53a being provided in the electrically conductive outer shield partway along the length of coaxial cable so as to divide the electrically conductive outer shield 53 into at least two axially spaced shield portions such that at least one of the shield portions acts as a radiating element when an RF source is connected to the feed point 52a.
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公开(公告)号：US20220268863A1
公开(公告)日：2022-08-25
申请号：US17369610
申请日：2021-07-07
发明人： Carel Costijn Van Leeuwen , Alexander Jan Eberhard Raaijmakers , Bart Romke Steensma , Martino Borgo , Catalina Sofia Arteaga De Castro , Cornelius Antonius Theodorus Van Den Berg , Dennis Wilhelmus Johannes Klomp
摘要： An MRI system RF transmit antenna arrangement 3 including an antenna 5 including a length of coaxial cable 51 with an electrically conductive core 52 and an electrically conductive outer shield 53 through which the core runs, with the core having a feed point 52a arranged for electrical connection to an RF source and at least one break 53a being provided in the electrically conductive outer shield partway along the length of coaxial cable so as to divide the electrically conductive outer shield 53 into at least two axially spaced shield portions such that at least one of the shield portions acts as a radiating element when an RF source is connected to the feed point 52a.
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公开(公告)号：US20220257952A1
公开(公告)日：2022-08-18
申请号：US17661845
申请日：2022-05-03
摘要： An example device for detecting one or more parameters of a cardiac signal is disclosed herein. The device includes one or more electrodes and sensing circuitry configured to sense a cardiac signal via the one or more electrodes. The device further includes processing circuitry configured to determine a representative signal based on the cardiac signal, the representative signal having a single polarity, and determine an end of a T-wave of the cardiac signal based on an area under the representative signal.
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公开(公告)号：US20220163611A1
公开(公告)日：2022-05-26
申请号：US17602259
申请日：2020-04-08
IPC分类号： G01R33/56 , G01R33/50 , G01R33/561
摘要： The present patent disclosure describes a new method and a new device for determining a spatial distribution of at N least one tissue parameter within a sample based on a time domain magnetic resonance, TDMR, signal emitted from the sample after excitation of the sample according to an applied pulse sequence. The spatial distribution is determined using a calculated sparse Hessian, wherein the sparse Hessian is calculated based on the applied pulse sequence.
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76.发明授权公开(公告)号：US11105725B2
公开(公告)日：2021-08-31
申请号：US15106064
申请日：2014-12-18
摘要： The invention relates to a computer implemented method of analysing data comprising measured values of characteristics of objects in samples, the data comprising —a first set of data (Xireference)′ with measured values of characteristics of objects in reference samples; —a test set of data (Xitest) with measured values of the characteristics of objects in a test sample; characterised by the method comprising; —fitting a control model to the first set of data to determine control loadings (Pcontrol) each representing an independent correlation between characteristics; —projecting the first set of data (Xireference) onto the control loadings (Pcontrol) for determining a first set control scores (Tcontrol,ireference) and determining one or more confidence intervals for the first set of control scores (Tcontrol,ireference); —projecting the test data onto the control loadings (Pcontrol) for determining test control scores; —determining if the test control scores are within one or more the confidence intervals.
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公开(公告)号：US11091562B2
公开(公告)日：2021-08-17
申请号：US17091890
申请日：2020-11-06
摘要： Provided herein are engineered antibodies that comprise a modified IgA heavy chain constant region, pharmaceutical compositions, and methods of use. The engineered antibodies described herein comprise one or more amino acid substitution or deletion in a constant region of an IgA domain. Further provided herein are methods of treating disorders, including cancer, by administering an engineered IgA antibody described herein.
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78.发明申请公开(公告)号：US20200368721A1
公开(公告)日：2020-11-26
申请号：US16769264
申请日：2018-12-04
申请人： Stichting voor de Technische Wetenschappen , Universiteit Utrecht Holding B.V. , UMC Utrecht Holding B.V.
发明人： Robert Smakman , Wilhelmus Everhardus Hennink , Karin Gerarda Frederika Gerritsen , Jacobus Adrianus Wilhelmus Jong , Cornelus Franciscus van Nostrum
IPC分类号： B01J20/26 , C08F212/14 , C08F212/32 , C08F8/06 , C08F8/20 , B01J20/28 , B01J20/34
摘要： The present invention relates to a method for preparing a macromolecular composition comprising indene-derivatives. The invention also relates to the macromolecular compositions per se, and to methods of using the macromolecular compositions. The macromolecular compositions are useful for undergoing subsequent reactions with small molecules.
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公开(公告)号：US10772525B2
公开(公告)日：2020-09-15
申请号：US16000037
申请日：2018-06-05
IPC分类号： A61B5/0452 , A61B5/00 , A61B5/021 , A61N1/37
摘要： An example device for detecting one or more parameters of a cardiac signal is disclosed herein. The device includes one or more electrodes and sensing circuitry configured to sense a cardiac signal via the one or more electrodes. The device further includes processing circuitry configured to determine a representative signal based on the cardiac signal, the representative signal having a single polarity, and determine an end of a T-wave of the cardiac signal based on an area under the representative signal.
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公开(公告)号：US20200205860A1
公开(公告)日：2020-07-02
申请号：US16802280
申请日：2020-02-26
IPC分类号： A61B17/70
摘要： A spinal distraction system including a bearing connector fastened to a fixated rod and a sliding rod, wherein the sliding rod includes a spring and a stop ring is disclosed. A method of distracting vertebrae is also disclosed.
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