公开(公告)号：US12209254B2

公开(公告)日：2025-01-28

申请号：US18182829

申请日：2023-03-13

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Carlos Marcelo Nicolas Rivolta ,  Sarah Louise Boddy

IPC: C07K16/28 ,  C07K16/18 ,  C07K16/30 ,  C12N5/0797 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569

Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.

公开(公告)号：US12201694B2

公开(公告)日：2025-01-21

申请号：US17055782

申请日：2019-05-17

Applicant: Hyderabad Eye Institute ,  UNIVERSITY OF BRADFORD ,  UNIVERSITY OF SHEFFIELD

Inventor： Prashant Garg ,  Stephen Rimmer ,  Charles William Ian Douglas

IPC: A61K47/69 ,  A61K9/06 ,  A61K31/7048 ,  A61K31/785 ,  A61K38/12 ,  A61K38/14 ,  A61K47/58 ,  A61P31/10 ,  C12Q1/04

Abstract: The present invention relates to hydrogel compositions comprising polymer conjugates capable of selectively binding to fungi, Gram positive bacteria and/or Gram negative bacteria. The hydrogel compositions can be used for detecting the presence of fungi, Gram positive bacteria and/or Gram negative bacteria in a sample.

公开(公告)号：US20240247226A1

公开(公告)日：2024-07-25

申请号：US17918666

申请日：2021-05-10

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Thomas James BURNS ,  Daniel James GILMOUR

IPC: C12N1/12 ,  C12M1/00 ,  C12M1/36 ,  C12R1/89

CPC classification number: C12N1/125 ,  C12M21/02 ,  C12M27/20 ,  C12M41/48 ,  C12R2001/89

Abstract: The present invention relates to a heterotrophic methods of culturing algae, particularly Galdieria species, to produce the valuable pigment phycocyanin. The methods rely on high oxygen saturation and controlled base dosing to provide improved phycocyanin production. The present invention further relates to algal biomass, compositions comprising said biomass or phycocyanin, uses thereof in various products, and a reactor for culturing the algae.

公开(公告)号：US20240241128A1

公开(公告)日：2024-07-18

申请号：US18286040

申请日：2022-04-08

Applicant: NeoGenomics Laboratories, Inc. ,  The University of Sheffield

Inventor： Claire Lewis ,  Anna Juncker-Jensen ,  Mate Levente ,  Nicholas Matthew Stavrou ,  Mohammed Ridha Moamin ,  Richard Allen

IPC: G01N33/574 ,  G01N33/569

CPC classification number: G01N33/57484 ,  G01N33/56972 ,  G01N33/57415 ,  G01N33/57434

Abstract: Provided herein are methods for determining the chance of a tumor not responding to an anti-cancer therapy (e.g., a T cell-based immunotherapy) based on the presence, density, number, and/or location of certain three-cell structures as described herein. The three-cell structures may comprise a T cell, an immunosuppressive tumor-associated macrophage, and an immunosuppressive regulatory T cell. Such methods may be useful for identifying patients not likely to respond to T cell-based immunotherapy. Also provided herein are methods for determining the prognosis and/or invasiveness of a tumor. The present disclosure also encompasses methods for treating a tumor, as well as kits for performing the methods disclosed herein.

公开(公告)号：US20240174480A1

公开(公告)日：2024-05-30

申请号：US18521941

申请日：2023-11-28

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Chris SCRAGGS ,  Adrian HIRST ,  John CARMICHAEL ,  James Edward Ramon LINDSAY

IPC: B65H59/02

CPC classification number: B65H59/02 ,  B65H2553/22 ,  B65H2553/61 ,  B65H2701/33 ,  B65H2701/34 ,  B65H2801/51

Abstract: A spool tension system is disclosed for a spooled multi-line elongate carrier connected between a ground vehicle and a spooling apparatus, in order to connect the ground vehicle to services. A terminal of the ground vehicle is coupled to one end of the elongate carrier via a sensing arrangement which is arranged to provide a signal indicating tension at the end of the elongate carrier. The spooling apparatus is arranged to spool the elongate carrier in response to the signal, such that the tension in the elongate carrier is regulated during movement of the ground vehicle.

公开(公告)号：US20230355178A1

公开(公告)日：2023-11-09

申请号：US18138387

申请日：2023-04-24

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Dilichukwu ANUMBA ,  Timothy James HEALEY

IPC: A61B5/00 ,  A61B5/0538 ,  G01R35/00

CPC classification number: A61B5/6843 ,  A61B5/0538 ,  A61B5/4331 ,  G01R35/005 ,  A61B5/435 ,  A61B2562/0219 ,  A61B2562/0252 ,  A61B2562/0261

Abstract: An apparatus for determining a force Ftip applied to a tip of an electrical impedance spectroscopy probe includes a load cell, accelerometer, and a processing means. The probe tip has a substantially planar distal end for contacting human or animal tissue. The load cell measures the force Floadcell applied axially along a longitudinal axis when the probe tip is in contact with human or animal tissue. The accelerometer measures a gravity vector Aaxial. The apparatus includes a means for compensating for the mass of the probe tip using the measured force and the gravity vector to produce a calibrated measurement force F applied to the probe tip.

公开(公告)号：US11634687B2

公开(公告)日：2023-04-25

申请号：US16329935

申请日：2017-09-14

Applicant: THE UNIVERSITY OF SHEFFIELD

Inventor： Carlos Marcelo Nicolas Rivolta ,  Sarah Louise Boddy

IPC: C07K16/28 ,  C07K16/30 ,  G01N33/48 ,  G01N33/50 ,  G01N33/53 ,  G01N33/569 ,  C12N5/0797 ,  C07K16/18

Abstract: The present invention relates generally to the identification and isolation of human otic progenitor cells. More specifically, the present invention relates to a method of using cell markers to identify and isolate human otic progenitor cells from a mixed population of cells, methods of enrichment and production of human otic progenitor cells, and associated kits for use in identification and/or isolation of human otic progenitor cells, wherein the cell markers are selected from SSEA1 (CD15), disialoganglioside GD3, TRA-2-49 (liver/bone/kidney alkaline phosphatase), SSEA4, ganglioside GD2 and CD141.

公开(公告)号：US20230090069A1

公开(公告)日：2023-03-23

申请号：US17904734

申请日：2021-03-05

Applicant: CENTRE HOSPITALIER UNIVERSITAIRE DE NIMES ,  HUMANITAS MIRASOLE SPA ,  THE UNIVERSITY OF SUSSEX ,  KING'S COLLEGE LONDON ,  QUEEN MARY UNIVERSITY OF LONDON ,  SORBONNE UNIVERSITE ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  THE UNIVERSITY OF SHEFFIELD

Inventor： Gilbert BENSIMON ,  Peter Nigel LEIGH ,  Timothy TREE ,  Cecilia GARLANDA ,  Massimo LOCATI ,  Janine KIRBY ,  Pamela SHAW ,  Andrea MALASPINA

IPC: A61K38/20 ,  A61K31/428 ,  A61P25/28

Abstract: The present invention is in the field of amyotrophic lateral sclerosis (ALS) and relates to human interleukin-2 (IL-2) for use in the treatment of amyotrophic lateral sclerosis in a human subject, wherein each dose of human IL-2 administered to said subject is between 0.1×106 to 3×106 international units (IU) Human IL-2 is preferably administered in cycles of 3 to 7 days of once-daily sub-cutaneous injection of 0.1×106 to 3×106 HI human IL-2. The treatment does not comprise the administration of regulatory T cells to the subject, who is preferably also under riluzole treatment. The administered human IL-2 is preferably not complexed with anti-hIL-2 antibodies and the treatment also preferably does not comprise the administration of rapamycin or any other suppressive agent of effector T cells (Teffs) to the subject. The treatment permits to decrease plasma CCL2 concentration and to change the polarization of blood macrophages from an M1 inflammatory phenotype to an anti-inflammatory M2 phenotype involved in tissue repair.

公开(公告)号：US20230038479A1

公开(公告)日：2023-02-09

申请号：US17791169

申请日：2021-02-02

Applicant: University of Sheffield

Inventor： Mimoun Azzouz ,  Christopher Webster

IPC: C12N9/14 ,  C12N15/86 ,  A61P25/28

Abstract: The present disclosure relates to transcription cassettes comprising nucleic acids encoding RuvBL1 and/or RuvBL2 and the use of said vectors in gene therapy for the treatment of neurodegenerative diseases that result from expression of polymorphic repeat expansions of the GGGGCC (SEQ ID NO: 5) hexanucleotide-repeat sequence in the first intron of the C9ORF72 gene; pharmaceutical compositions comprising said vectors and including uses and methods to treat neurodegenerative diseases.

公开(公告)号：US11535859B1

公开(公告)日：2022-12-27

申请号：US16608683

申请日：2018-04-26

Applicant: The University of Sheffield

Inventor： Julie Elizabeth Gray ,  Lee Hunt ,  William Paul Quick

IPC: C12N15/82 ,  C07K14/415

Abstract: The present invention relates to the modification of gene expression in plants in order to manipulate stomatal number, in particular to the modification of expression in plants of epidermal patterning factor (EPF). The invention also relates to genetically modified plants or plant parts with altered stomatal patterning compared to corresponding wild type plants or plant parts, where the plant stomatal development is altered by modification of the expression of EPF.