公开(公告)号：US20240374612A1

公开(公告)日：2024-11-14

申请号：US18690342

申请日：2022-09-08

Applicant: UWM Research Foundation, Inc. ,  Centre for Addiction and Mental Health

Inventor： Thomas Damien Prevot ,  Michael Jeffrey Marcotte ,  Etienne Laurent Sibille ,  James M. Cook ,  Guangan Li ,  Prithu Mondal ,  Md Yeunus Mian ,  Farjana Rashid

IPC: A61K31/5517 ,  A61P25/00 ,  C07D487/04

Abstract: 4H-Benzo[f]imidazo [1,5-a][1,4]diazepines substituted in the 3-position with an amide or oxadiazole and their pharmaceutical compositions display efficacy to enhance cognition and may have utility in the treatment of cognitive deficiencies, such as in neurodegenerative and neuropsychiatric disorders.

公开(公告)号：US12121552B2

公开(公告)日：2024-10-22

申请号：US18120528

申请日：2023-03-13

Applicant: T3 Bioscience, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A61K35/74 ,  A61K31/05 ,  A61P31/04

CPC classification number: A61K35/74 ,  A61K31/05 ,  A61P31/04

Abstract: The present invention relates to an antimicrobial composition and probiotics against bacterial and fungal pathogens of fish. In particular, the invention pertains to a novel strain of the bacterial species Pseudomonas chlororaphis subsp. aurantiaca 1214-CHY4 (ATCC accession number PTA-126941), the cells, cell broth, and novel metabolites produced from the bacterial strain that can inhibit the growth of a variety of fish pathogens.

公开(公告)号：US12089595B2

公开(公告)日：2024-09-17

申请号：US17493594

申请日：2021-10-04

Applicant: T3 Bioscience, Inc. ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Jian Huang

IPC: A01N43/40 ,  A01N63/27 ,  A01P1/00 ,  A01P3/00

CPC classification number: A01N43/40 ,  A01N63/27 ,  A01P1/00 ,  A01P3/00

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops and fungal pathogens. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20240002262A1

公开(公告)日：2024-01-04

申请号：US18215966

申请日：2023-06-29

Applicant: UWM Research Foundation, Inc.

Inventor： Shangping Xu ,  Yin Wang ,  Jingwan Huo

IPC: C02F1/28 ,  B01J20/22 ,  B01J20/08 ,  B01J20/02 ,  B01J20/32

CPC classification number: C02F1/288 ,  B01J20/223 ,  B01J20/08 ,  B01J20/0296 ,  B01J20/0248 ,  B01J20/0244 ,  B01J20/3219 ,  B01J20/3257 ,  B01J20/3204 ,  C02F2101/36

Abstract: The present invention is directed at functionalized layered double hydroxides, including methods of their preparation, that are suitable for treatment of water contaminated with per- and polyfluoroalkyl substances.

公开(公告)号：US11753412B2

公开(公告)日：2023-09-12

申请号：US17122745

申请日：2020-12-15

Applicant: UWM Research Foundation, Inc. ,  Centre for Addiction and Mental Health ,  University of Belgrade—Faculty of Pharmacy

Inventor： James M. Cook ,  Guanguan Li ,  Michael Ming-Jin Poe ,  Miroslav M. Savic ,  Etienne Sibille

IPC: C07D487/04 ,  A61K31/5517 ,  A61P25/00 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

CPC classification number: C07D487/04 ,  A61P25/22

Abstract: Provided herein are alpha5-containing GABAA receptor agonists and pharmaceutical compositions and methods of treatment of cognitive and mood symptoms in neurodegenerative and neuropsychiatric disorders using them.

公开(公告)号：US11582973B2

公开(公告)日：2023-02-21

申请号：US17063540

申请日：2020-10-05

Applicant: T3 BIOSCIENCE, LLC ,  UWM RESEARCH FOUNDATION, INC.

Inventor： Ching-Hong Yang ,  Xiangyang Liu

IPC: A01N63/27 ,  C12N1/20 ,  C07D213/90 ,  C07D491/048 ,  A61K35/74

Abstract: The present disclosure concerns methods of using novel bacterial strains of 0617-T307, 0917-T305, 0917-T306, 0917-T307, 0118-T319, 0318-T327, and 0418-T328, the cell broth and novel metabolites produced from the bacterial strains, that can inhibit the growth of a variety of microbial species for a variety of crops. The methods include use of novel, potent antimicrobial metabolites produced from the strains corresponding to compounds having Formulas (I), (II), and (III):

公开(公告)号：US20220154452A1

公开(公告)日：2022-05-19

申请号：US17592073

申请日：2022-02-03

Applicant: UWM Research Foundation, Inc.

Inventor： Jian Zhao

IPC: E04B1/41 ,  E21B10/44

Abstract: A cured concrete and stone bore working tool and method of forming radially oriented discontinuities in a bore or perforation formed in a cured concrete or stone material such that, after use or application of the tool, the perforation formed in the cured concrete or stone material is configured to provide a non-planar adhesive interface and isolate a properly sized anchor or fastener from direct contact with the wall of the bore. Fasteners or anchors adhesively secured in bores previously treated with the bore treating tool exhibit improved creep failure performance as compared to fasteners adhesively secured to untreated bores.

公开(公告)号：US20220079952A1

公开(公告)日：2022-03-17

申请号：US17612877

申请日：2020-05-22

Applicant: Emory University ,  UWM Research Foundation, Inc.

Inventor： Soma Sengupta ,  Daniel Pommeranz Krummel ,  Mohammad Khan ,  Tahseen Nasti ,  James Cook

IPC: A61K31/5513 ,  C07K16/28 ,  A61K39/395

Abstract: This disclosure relates to uses of radiation and benzodiazepines optionally in combination with other anticancer agents for treating cancer. In certain embodiments, this disclosure relates to methods of using radiation, benzodiazepines, and check point inhibitors in cancer therapies.

公开(公告)号：US20210340155A1

公开(公告)日：2021-11-04

申请号：US16498122

申请日：2018-03-30

Applicant: Marquette University ,  Concordia University, Inc. ,  UWM Research Foundation, Inc.

Inventor： William A. Donaldson ,  Daniel S. Sem ,  Karyn M. Frick

IPC: C07D493/08 ,  A61P25/28 ,  C07C35/21

Abstract: Disclosed are substituted (4′-hydroxylphenyl)cycloalkane compounds and substituted (4′-hydroxylphenyl)cycloalkene compounds and there use as selective agonists of the estrogen receptor beta isoform (ERβ). The disclosed compounds may be formulated as pharmaceutical compositions and administered for treating diseases associated with ER activity, such as neurological, psychiatric, and/or cell proliferative diseases and disorders as well as for enhancing memory consolidation in subjects in need thereof.

公开(公告)号：US11149062B2

公开(公告)日：2021-10-19

申请号：US15755701

申请日：2015-10-29

Applicant: UWM Research Foundation, Inc.

Inventor： Yi-Qiang Cheng ,  M. Mahmun Hossain ,  Douglas Steeber ,  Karyn Frick ,  Steven Clark ,  Joseph Ulicki

IPC: C07K5/062 ,  C07C323/52 ,  A61K38/00

Abstract: Disclosed herein are novel HDAC inhibitors. The HDAC inhibitors may be used in methods of treating cancer. The HDAC inhibitors may be used in methods of treating a neurological disorder.