公开(公告)号：US20090088555A1

公开(公告)日：2009-04-02

申请号：US12274626

申请日：2008-11-20

申请人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： C07K14/00 ,  C07H21/04 ,  C07K16/18

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US20080113354A1

公开(公告)日：2008-05-15

申请号：US11718761

申请日：2005-11-14

申请人： Yanggu Shi ,  Gary F. Gerard

发明人： Yanggu Shi ,  Gary F. Gerard

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/683 ,  C12Q2563/107 ,  C12Q2537/113 ,  C12Q2521/514 ,  C12Q2549/119 ,  C12Q2525/161 ,  C12Q2525/155

摘要： Methods and kits are provided with DNA substrates having a fluorescent label positioned at a nucleotide internal from its 5′ end for use with CEL nuclease to determine whether a DNA sequence contains mutations or polymorphic changes.

摘要翻译： 提供方法和试剂盒具有荧光标记的DNA底物，荧光标记位于其5'末端的核苷酸处，以与CEL核酸酶一起使用以确定DNA序列是否含有突变或多态性变化。

公开(公告)号：US20070269439A1

公开(公告)日：2007-11-22

申请号：US11567524

申请日：2006-12-06

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： A61K39/395 ,  C12Q1/68 ,  G01N33/567 ,  C07H21/04 ,  G01N33/53 ,  C07K14/715 ,  C07K16/28

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

公开(公告)号：US06770466B2

公开(公告)日：2004-08-03

申请号：US09906779

申请日：2001-07-18

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： C12N912

CPC分类号： C12N9/16 ,  A61K38/00

摘要： The present invention relates to novel human PTPase polypeptides and isolated nucleic acids containing the coding regions of the genes encoding such polypeptides. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human PTPase polypeptides. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human PtPase polypeptides.

摘要翻译： 本发明涉及新的人PTPase多肽和含有编码这些多肽的基因的编码区的分离的核酸。 还提供了用于产生人PTPase多肽的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人PtPase多肽相关的疾病的诊断和治疗方法。

公开(公告)号：US06569992B1

公开(公告)日：2003-05-27

申请号：US09369247

申请日：1999-08-05

申请人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

发明人： David W. LaFleur ,  Steven M. Ruben ,  Craig A. Rosen ,  Paul A. Moore ,  Yanggu Shi ,  Hla Kyaw ,  Ying-Fei Wei

IPC分类号： A61K3800

CPC分类号： C12Q1/6883 ,  A61K35/13 ,  A61K38/00 ,  C07K14/47 ,  G01N33/6893 ,  Y02A50/465

摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.

摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。

公开(公告)号：US07638603B2

公开(公告)日：2009-12-29

申请号：US11567524

申请日：2006-12-06

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： C07K16/00 ,  C12P21/08

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

公开(公告)号：US06849719B2

公开(公告)日：2005-02-01

申请号：US09796844

申请日：2001-03-02

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： A61K38/00 ,  C07K14/715 ,  C07K16/28 ,  C07K16/00

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K14/54 ,  C07K16/2866 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/715

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

公开(公告)号：US08133734B2

公开(公告)日：2012-03-13

申请号：US12618178

申请日：2009-11-13

申请人： Yanggu Shi ,  Stephen M. Ruben

发明人： Yanggu Shi ,  Stephen M. Ruben

IPC分类号： C07K16/00 ,  C07K17/00

CPC分类号： C07K16/2866 ,  C07K2317/76 ,  G01N33/6869 ,  G01N2333/7155 ,  G01N2800/24 ,  Y10S435/81 ,  Y10S436/808

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

公开(公告)号：US20100143246A1

公开(公告)日：2010-06-10

申请号：US12618178

申请日：2009-11-13

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： A61K51/10 ,  A61K39/395 ,  A61P35/00 ,  A61P25/00 ,  A61P37/00 ,  A61P19/02 ,  A61P19/08 ,  G01N33/53

CPC分类号： C07K16/2866 ,  C07K2317/76 ,  G01N33/6869 ,  G01N2333/7155 ,  G01N2800/24 ,  Y10S435/81 ,  Y10S436/808

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating, diagnosing, detecting, and/or preventing immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗，诊断，检测和/或预防免疫系统相关疾病的治疗方法。

公开(公告)号：US06635443B1

公开(公告)日：2003-10-21

申请号：US09154219

申请日：1998-09-16

申请人： Yanggu Shi ,  Steven M. Ruben

发明人： Yanggu Shi ,  Steven M. Ruben

IPC分类号： C12N1500

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C12N2799/026

摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.

摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。