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公开(公告)号：US20110003383A1
公开(公告)日：2011-01-06
申请号：US12268263
申请日：2008-11-10
申请人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
发明人： Steven M. Ruben , George A. Komatsoulis , D. Roxanne Duan , Craig A. Rosen , Paul A. Moore , Yanggu Shi , David W. LaFleur , Reinhard Ebner , Henrik S. Olsen , Laurie A. Brewer , Kimberly A Florence , Paul E. Young , Michael Mucenski , Gregory A. Endress , Daniel R. Soppet
CPC分类号： C07K14/47 , A61K38/00 , C07K2319/30
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20100291033A1
公开(公告)日：2010-11-18
申请号：US12793652
申请日：2010-06-03
申请人： Craig A. ROSEN , Adam Bell , Paul A. Moore , Yanggu Shi , David W. LaFleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
发明人： Craig A. ROSEN , Adam Bell , Paul A. Moore , Yanggu Shi , David W. LaFleur , Jason B. Bock , Michael W. Laird , William A. Haseltine , Douglas B. Woods , Mani Subramanian
IPC分类号： A61K38/38 , C07K14/76 , A61K38/21 , C07H21/04 , A61P31/18 , A61P35/00 , A61P31/12 , A61P9/12 , A61P9/04 , A61P35/02 , A61P31/04 , A61P3/10 , C12N5/10 , C12N1/19 , C12N1/21
CPC分类号： C07K14/765 , A61K38/38 , A61K47/643 , C07K2319/31
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译： 本发明包括白蛋白融合蛋白。 编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法 酸，载体和/或宿主细胞。 另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。
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公开(公告)号：US20090253626A1
公开(公告)日：2009-10-08
申请号：US12325800
申请日：2008-12-01
申请人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
发明人： Paul A. Moore , Steven M. Ruben , David W. LaFleur , Yanggu Shi , Craig A. Rosen , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N5/00 , G01N33/53 , C07K14/435 , C07K16/00 , C12P21/06
CPC分类号： C07H21/04 , A61K38/00 , A61K48/00 , C07K14/47 , G01N2800/042
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
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公开(公告)号：US07053190B2
公开(公告)日：2006-05-30
申请号：US09981876
申请日：2001-10-19
申请人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
发明人： Steven M. Ruben , Craig A. Rosen , Carrie L. Fischer , Daniel R. Soppet , Kenneth C. Carter , Daniel P. Bednarik , Gregory A. Endress , Guo-Liang Yu , Jian Ni , Ping Feng , Paul E. Young , John M. Greene , Ann M. Ferrie , Roxanne Duan , Jing-Shan Hu , Kimberly A. Florence , Henrik S. Olsen , Reinhard Ebner , Laurie A. Brewer , Yanggu Shi
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/28 , A61K38/00 , C07K14/47 , C07K14/4702 , C07K14/4718 , C12N15/11 , G01N33/68
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
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公开(公告)号：US06953667B2
公开(公告)日：2005-10-11
申请号：US10054988
申请日：2002-01-25
申请人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
发明人： Paul A. Moore , Steven M. Ruben , Henrik S. Olsen , Yanggu Shi , Craig A. Rosen , Kimberly A. Florence , Daniel R. Soppet , David W. LaFleur , Gregory A. Endress , Reinhard Ebner , George Komatsoulis , Roxanne D. Duan
IPC分类号： G01N33/50 , A61K38/00 , A61K48/00 , A61P9/00 , A61P9/10 , A61P25/02 , A61P25/12 , A61P25/16 , A61P25/18 , A61P25/28 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/68 , G01N33/15 , G01N33/53 , C07K16/22 , C07K17/02 , C12N9/96
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050214844A1
公开(公告)日：2005-09-29
申请号：US11111953
申请日：2005-04-22
申请人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
发明人： Paul Moore , Yanggu Shi , Craig Rosen , Steven Ruben , David Lafleur , Henrik Olsen , Reinhard Ebner , Laurie Brewer , Paul Young , John Greene , Ann Ferrie , Guo-Liang Yu , Jian Ni , Ping Feng
IPC分类号： G01N33/53 , A61K38/00 , A61K48/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/04 , C12N5/06 , C12N5/10 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/10 , C12N15/11 , C12N15/12 , C12P21/02 , C12P21/04 , C12P21/06 , C12Q1/68 , G01N33/566
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US06936691B2
公开(公告)日：2005-08-30
申请号：US09832129
申请日：2001-04-11
申请人： Michele Fiscella , Ping Wei , David W. LaFleur , Henrik S. Olsen , Kevin P. Baker , Reinhard Ebner , George A. Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul E. Young , Kimberly A. Florence , Paul A. Moore , Charles E. Birse , Jian Ni , Daniel R. Soppet , Yanggu Shi
发明人： Michele Fiscella , Ping Wei , David W. LaFleur , Henrik S. Olsen , Kevin P. Baker , Reinhard Ebner , George A. Komatsoulis , Craig A. Rosen , Steven M. Ruben , Roxanne D. Duan , Paul E. Young , Kimberly A. Florence , Paul A. Moore , Charles E. Birse , Jian Ni , Daniel R. Soppet , Yanggu Shi
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P3/10 , A61P9/00 , A61P9/10 , A61P27/02 , A61P35/00 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/19 , C07K1/00
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译： 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US06482923B1
公开(公告)日：2002-11-19
申请号：US09268311
申请日：1999-03-16
申请人： Yanggu Shi , Steve M. Ruben
发明人： Yanggu Shi , Steve M. Ruben
IPC分类号： C07K14705
CPC分类号： C07K14/7155 , A61K38/00 , C12N2799/026
摘要： The present invention relates to a novel IL17RLP protein which is a member of the interleukin (IL)-17 receptor family. In particular, isolated nucleic acid molecules are provided encoding the human IL17RLP protein. IL17RLP polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of IL17RLP activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
摘要翻译： 本发明涉及作为白介素（IL）-17受体家族成员的新型IL17RLP蛋白。 特别地，提供编码人IL17RLP蛋白质的分离的核酸分子。 还提供IL17RLP多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定IL17RLP活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US6046035A
公开(公告)日：2000-04-04
申请号：US106182
申请日：1998-06-29
申请人： Yanggu Shi , Steven M. Ruben
发明人： Yanggu Shi , Steven M. Ruben
IPC分类号： C12N15/09 , A61K38/00 , C07K14/435 , C07K14/52 , C07K14/54 , C07K16/24 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/19 , C12N15/24 , C12P21/04 , C12P21/08
摘要： The present invention relates to a novel CLC protein which is a member of the IL-6 cytokine family. In particular, isolated nucleic acid molecules are provided encoding the human CLC protein. CLC polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of CLC activity. Also provided are diagnostic methods for detecting cardiac and immune system-related disorders and therapeutic methods for treating cardiac and immune system-related disorders.
摘要翻译： 本发明涉及作为IL-6细胞因子家族成员的新型CLC蛋白。 特别地，提供编码人CLC蛋白的分离的核酸分子。 还提供CLC多肽，载体，宿主细胞和用于制备它的重组方法。 本发明还涉及鉴定CLC活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测心脏和免疫系统相关疾病的诊断方法以及用于治疗心脏和免疫系统相关疾病的治疗方法。
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10.发明申请公开(公告)号：US20120225421A1
公开(公告)日：2012-09-06
申请号：US13407274
申请日：2012-02-28
CPC分类号： C12Q1/6806 , C12Q1/6869 , C12Q1/708 , C12Q2527/107 , C12Q2535/113 , C12Q2537/163
摘要： Methods and kits for sequencing a target DNA sequence in a sample having a related reference sequence are provided herein. In particular, kits and methods for sequencing cancer and cancer therapy associated mutations are described. Also provided are kits and methods for detecting mitochondrial mutations and for differentiating between closely related viral strains.
摘要翻译： 本文提供了用于测序具有相关参考序列的样品中的靶DNA序列的方法和试剂盒。 具体地，描述了用于测序癌症和癌症治疗相关突变的试剂盒和方法。 还提供了用于检测线粒体突变和用于区分密切相关的病毒株之间的试剂盒和方法。
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