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71.发明授权Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands 有权杂环取代环丙烷作为促肾上腺皮质激素释放激素配体公开(公告)号：US07297708B2
公开(公告)日：2007-11-20
申请号：US10235436
申请日：2002-09-05
申请人： Andreas Termin , Peter D. J. Grootenhuis , Dean M. Wilson , Valentina Molteni , Long Mao , Angelo Castellino , Zhicai Yang , Anthony Pechulis , Mark Suto
发明人： Andreas Termin , Peter D. J. Grootenhuis , Dean M. Wilson , Valentina Molteni , Long Mao , Angelo Castellino , Zhicai Yang , Anthony Pechulis , Mark Suto
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D213/30 , C07D233/64 , C07D239/26 , C07D241/12 , C07D249/08
摘要： Provided herein are novel heteroaromatic substituted cyclopropanes of the Formula (I): as well as compositions, including pharmaceutical compositions, containing the same, and the use thereof in the treatment of various neurological and psychological disorders, e.g., anxiety and depression, treatable by antagonizing CRF receptors.
摘要翻译： 本文提供了式（I）的新型杂芳族取代的环丙烷：以及包含其的组合物，包括药物组合物，以及其用于治疗各种神经和心理障碍，例如焦虑和抑郁症的用途，可通过拮抗 CRF受体。
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公开(公告)号：US20070043023A1
公开(公告)日：2007-02-22
申请号：US11359960
申请日：2006-02-22
申请人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
发明人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
IPC分类号： A61K31/55 , A61K31/4747
CPC分类号： A61K31/4747 , A61K31/435 , A61K31/438 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/06 , C07D451/02 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20060079505A1
公开(公告)日：2006-04-13
申请号：US11208386
申请日：2005-08-19
申请人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
发明人： Lewis Makings , Miguel Blanco , Dennis Hurley , Ioana Drutu , Gabriel Raffai , Daniele Bergeron , Akiko Nakatani , Andreas Termin , Alina Silina
IPC分类号： A61K31/55 , A61K31/4747 , C07D225/04 , C07D223/14
CPC分类号： C07D401/06 , A61K31/435 , A61K31/438 , A61K31/4747 , A61K31/55 , C07D221/20 , C07D223/32 , C07D405/04 , C07D405/06 , C07D405/12 , C07D451/02 , C07D451/04 , C07D471/10 , C07D491/10
摘要： The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
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公开(公告)号：US20060074076A1
公开(公告)日：2006-04-06
申请号：US11165254
申请日：2005-06-22
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/405 , A61K31/381 , A61K31/343
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
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公开(公告)号：US07022690B2
公开(公告)日：2006-04-04
申请号：US11020751
申请日：2004-12-23
申请人： Kevin Koch , Andreas Termin , John A. Josey
发明人： Kevin Koch , Andreas Termin , John A. Josey
IPC分类号： C07D225/02 , A61K31/395
CPC分类号： C07D223/12
摘要： Selected novel carboxylic acid substituted heterocycle compounds are effective for prophylaxis and treatment of inflammation, tissue degradation, cancer, fibrosis and related diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of inflamation, tissue degradation and related diseases. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
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公开(公告)号：US07786137B2
公开(公告)日：2010-08-31
申请号：US11429801
申请日：2006-05-08
申请人： Aarti S. Kawatkar , Tara M. Whitney , Timothy D. Neubert , Nicole Zimmermann , Andreas Termin , Esther Martinborough
发明人： Aarti S. Kawatkar , Tara M. Whitney , Timothy D. Neubert , Nicole Zimmermann , Andreas Termin , Esther Martinborough
IPC分类号： C07D417/12 , A61K31/47
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
摘要翻译： 具有式（I）的双环衍生物及其组合物可用作离子通道拮抗剂：
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公开(公告)号：US20100204255A1
公开(公告)日：2010-08-12
申请号：US12761502
申请日：2010-04-16
申请人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez-Botella , Esther Martinborough
发明人： Andreas Termin , Nicole Zimmermann , Tara Leanne Knoll , Gabriel Martinez-Botella , Esther Martinborough
IPC分类号： A61K31/506 , A61K31/4709 , A61P19/02 , A61P25/06 , A61P25/22 , A61P25/24 , A61P29/00 , C07D401/12 , C07D403/12 , C12N5/02
CPC分类号： C07D417/12 , C07D401/12
摘要： The present invention relates to bicyclic compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的双环化合物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07569604B2
公开(公告)日：2009-08-04
申请号：US11165254
申请日：2005-06-22
IPC分类号： A61K31/343 , A61K31/443 , A61K31/4525 , A61K31/4545 , A61K31/495 , A61K31/5377 , C07D405/12 , C07D405/14 , C07D407/14
CPC分类号： A61K31/405 , A61K31/343 , A61K31/381 , A61K31/404 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55
摘要： Heterocyclic derivatives act as Ca channel antagonists. The compositions are useful for treating or relieving Ca channel mediated conditions.
摘要翻译： 杂环衍生物作为Ca通道拮抗剂。 该组合物可用于治疗或缓解Ca通道介导的病症。
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公开(公告)号：US20090012117A1
公开(公告)日：2009-01-08
申请号：US11429801
申请日：2006-05-08
申请人： Aarti S. Kawatkar , Tara M. Whitney , Timothy D. Neubert , Nicole Zimmermann , Andreas Termin , Esther Martinborough
发明人： Aarti S. Kawatkar , Tara M. Whitney , Timothy D. Neubert , Nicole Zimmermann , Andreas Termin , Esther Martinborough
IPC分类号： A61K31/4725 , C07D417/12 , C07D417/14 , A61P25/00 , A61P25/06 , A61K31/428 , A61K31/427
CPC分类号： C07D417/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Bicyclic derivatives having formula (I) and a composition thereof are useful as ion channel antagonists:
摘要翻译： 具有式（I）的双环衍生物及其组合物可用作离子通道拮抗剂：
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公开(公告)号：US20080113990A1
公开(公告)日：2008-05-15
申请号：US11546669
申请日：2006-10-12
申请人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
发明人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
IPC分类号： A61K31/53 , A61K31/501 , A61K31/433 , A61K31/427 , A61K31/4245
CPC分类号： C07D417/12 , C07D275/03 , C07D277/44
摘要： Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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