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公开(公告)号：US07683083B2
公开(公告)日：2010-03-23
申请号：US11546669
申请日：2006-10-12
申请人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
发明人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
IPC分类号： A61K31/425 , C07D277/04
CPC分类号： C07D417/12 , C07D275/03 , C07D277/44
摘要： Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US20100130548A1
公开(公告)日：2010-05-27
申请号：US12697671
申请日：2010-02-01
申请人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
发明人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
IPC分类号： A61K31/4709 , A61K31/426 , C12N5/00
CPC分类号： C07D417/12 , C07D275/03 , C07D277/44
摘要： Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US20080113990A1
公开(公告)日：2008-05-15
申请号：US11546669
申请日：2006-10-12
申请人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
发明人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Zimmermann , Andreas Termin
IPC分类号： A61K31/53 , A61K31/501 , A61K31/433 , A61K31/427 , A61K31/4245
CPC分类号： C07D417/12 , C07D275/03 , C07D277/44
摘要： Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US08236833B2
公开(公告)日：2012-08-07
申请号：US12697671
申请日：2010-02-01
申请人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
发明人： Esther Martinborough , Danielle Lehsten , Timothy Neubert , Aarti Sameer Kawatkar , Nicole Hilgraf , Andreas Termin
IPC分类号： A61K31/425
CPC分类号： C07D417/12 , C07D275/03 , C07D277/44
摘要： Biphenyl derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了可用作离子通道拮抗剂的联苯衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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公开(公告)号：US20080027067A1
公开(公告)日：2008-01-31
申请号：US11643622
申请日：2006-12-21
申请人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人： Esther Martinborough , Lev Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Arati Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号： A61K31/495 , A61K31/426 , A61P29/00 , C07D401/00 , C07D403/00 , C07D277/02 , A61K31/445
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US07799822B2
公开(公告)日：2010-09-21
申请号：US11643622
申请日：2006-12-21
申请人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
发明人： Esther Martinborough , Lev T. D. Fanning , Urvi Sheth , Dean Wilson , Andreas Termin , Timothy Neubert , Nicole Zimmermann , Tara Knoll , Tara Whitney , Aarti Kawatkar , Danielle Lehsten , Dean Stamos , Jinglan Zhou , Vijayalaksmi Arumugam , Corey Gutierrez
IPC分类号： A01N43/36
CPC分类号： C07D417/12 , C07D239/42 , C07D401/12 , C07D405/12 , C07D417/14 , C07D471/10 , C07D491/10
摘要： The present invention relates to phenyl sulfonamides useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including for example the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的苯基磺酰胺。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病（包括例如治疗疼痛）的方法。
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7.发明授权Pyrrolidinone benzenesulfonamide derivatives as modulators of ion channels for the treatment of pain 有权吡咯烷酮苯磺酰胺衍生物作为离子通道的调节剂治疗疼痛公开(公告)号：US07994166B2
公开(公告)日：2011-08-09
申请号：US12269108
申请日：2008-11-12
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC分类号： A61K31/5355 , C07D417/14
CPC分类号： C07D417/14
摘要： The present invention relates to pyrrolidinone benzenesulfonamide derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of pain.
摘要翻译： 本发明涉及可用作离子通道抑制剂的吡咯烷酮苯磺酰胺衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗疼痛的方法。
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8.发明申请PYRROLIDINONE BENZENESULFONAMIDE DERIVATIVES AS MODULATORS OF ION CHANNELS FOR THE TREATMENT OF PAIN 审中-公开作为治疗疼痛的离子通道的调节剂，吡咯烷酮苯并呋喃衍生物公开(公告)号：US20120010416A1
公开(公告)日：2012-01-12
申请号：US13178877
申请日：2011-07-08
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC分类号： C07D417/14
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及可用作离子通道抑制剂的杂环衍生物。 本发明还提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US20090131440A1
公开(公告)日：2009-05-21
申请号：US12269108
申请日：2008-11-12
申请人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
发明人： Dean Stamos , Esther Martinborough , Nicole Zimmermann , Timothy Neubert , Mehdi Michel Djamel Numa , Tara Whitney , Aarti Sameer Kawatkar
IPC分类号： A61K31/5377 , C07D417/14 , A61K31/454 , A61P25/00
CPC分类号： C07D417/14
摘要： The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US07855220B2
公开(公告)日：2010-12-21
申请号：US11517754
申请日：2006-09-08
IPC分类号： A61K31/426 , A61K31/4245 , A61K31/425 , C07D277/52 , C07D271/07 , C07D271/113 , C07D275/03
CPC分类号： C07D417/12 , C07D277/52
摘要： Bicyclic derivatives useful as ion channel antagonists are disclosed herein. The compositions thereof are useful for treating or relieving pain-related conditions.
摘要翻译： 本文公开了用作离子通道拮抗剂的双环衍生物。 其组合物可用于治疗或缓解疼痛相关病症。
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