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公开(公告)号：US20050267200A1
公开(公告)日：2005-12-01
申请号：US11178164
申请日：2005-07-08
IPC分类号： A61K31/381 , A61K31/397 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P31/10 , A61P33/00 , A61P35/00 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12 , C07D417/12 , C07D521/00 , C07D333/72 , C07D409/02
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
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公开(公告)号：US06964974B2
公开(公告)日：2005-11-15
申请号：US09939872
申请日：2001-08-27
申请人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
发明人： Jean Ackermann , Johannes Aebi , Alexander Chucholowski , Henrietta Dehmlow , Olivier Morand , Sabine Wallbaum , Thomas Weller
IPC分类号： A61K31/445 , A61K31/4523 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P1/16 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P31/10 , A61P33/00 , A61P35/00 , A61P43/00 , C07D211/18 , C07D211/22 , C07D211/26 , C07D211/44 , C07D211/46 , C07D211/96 , C07D401/12 , C07D405/12 , C07D417/12
CPC分类号： C07D211/46 , C07D211/22 , C07D211/26 , C07D211/96
摘要： The present invention relates to piperidine derivatives useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，真菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病的哌啶衍生物 ，以及治疗和/或预防糖耐量异常和糖尿病。
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公开(公告)号：US06951879B2
公开(公告)日：2005-10-04
申请号：US09999424
申请日：2001-10-31
IPC分类号： A61K31/381 , A61K31/397 , A61K31/428 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61P3/00 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P13/12 , A61P31/10 , A61P33/00 , A61P35/00 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12 , C07D417/12 , C07D521/00
CPC分类号： C07D417/12 , C07D231/12 , C07D233/56 , C07D249/08 , C07D275/04 , C07D275/06 , C07D333/54 , C07D409/12
摘要： The present invention relates to heteroaromate OSC inhibitors. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.
摘要翻译： 本发明涉及异离子OSC抑制剂。 该化合物可用于治疗和/或预防与2,3-氧化山梨醇 - 羊毛甾醇环化酶如高胆固醇血症，高脂血症，动脉硬化，血管疾病，霉菌病，胆结石，肿瘤和/或过度增殖性疾病相关的疾病，以及治疗和 /或预防糖耐量异常和糖尿病。
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公开(公告)号：US06660738B2
公开(公告)日：2003-12-09
申请号：US09906983
申请日：2001-07-17
IPC分类号： C07D40104
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention relates to pyrrolidine derivatives useful as inhibitors of metalloproteases, e.g. zinc proteases, and which are effective in treating disease states associated with vasoconstriction.
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公开(公告)号：US6034275A
公开(公告)日：2000-03-07
申请号：US762827
申请日：1996-12-06
申请人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synese Jolidon , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Ku-Hua Ji
发明人： Johannes Aebi , Henrietta Dehmlow , Jacques Himber , Synese Jolidon , Hans Lengsfeld , Olivier Morand , Gerard Schmid , Ku-Hua Ji
IPC分类号： C07D249/08 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/275 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/445 , A61P3/06 , A61P9/00 , A61P31/04 , A61P31/10 , C07C211/08 , C07C211/15 , C07C211/16 , C07C217/20 , C07C217/46 , C07C217/52 , C07C217/76 , C07C225/22 , C07C235/78 , C07C235/84 , C07C237/06 , C07C255/56 , C07C255/58 , C07C311/04 , C07C317/16 , C07C323/10 , C07C323/22 , C07C323/25 , C07D207/08 , C07D211/46 , C07D211/58 , C07D213/64 , C07D233/60 , C07D257/04 , C07D309/12 , C07D333/20 , C07D333/22 , C07C213/00
CPC分类号： C07C323/25 , C07C217/20 , C07C217/46 , C07C217/52 , C07C235/78 , C07C235/84 , C07C255/56 , C07C311/04 , C07C323/22 , C07D211/46 , C07D211/58 , C07D213/64 , C07D333/22 , C07C2101/02
摘要： Tertiary amines of the formula ##STR1## wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, L, M, p, T, and Q are as defined herein, have antimycotic and cholesterol-lowering activity.
摘要翻译： 下式的叔胺其中A1，A2，A3，A4，L，M，p，T和Q如本文所定义，具有抗真菌和降低胆固醇的活性。
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