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82 条记录 (耗时 0.046 秒)

    Benzothiazole derivatives and medicinal products containing them
    72.
    发明授权
    Benzothiazole derivatives and medicinal products containing them 失效
    苯并噻唑衍生物和含有它们的药用产品

    公开(公告)号：US5340824A

    公开(公告)日：1994-08-23

    申请号：US938153

    申请日：1992-12-02

    申请人： Claude Gueremy ,  Patrick Jimonet ,  Serge Mignani

    发明人： Claude Gueremy ,  Patrick Jimonet ,  Serge Mignani

    IPC分类号： A61K31/445 ,  A61P25/28 ,  C07D277/82 ,  C07D417/12 ,  A61K31/44

    CPC分类号： C07D277/82

    摘要： ##STR1## Compounds of formula (I), in which R
    1 is a polyfluoralkoxy, R
    2 is a sulphur or nitrogen atom substituted by an alkyl radical or a sulfonyl or sulfinyl radical, R
    3 is a phenyl, benzoyl, --NR
    4 R
    5 or piperidinyl-4radical substituted in position 1 by a phenylalkyl radical, R
    4 is an alkyl radical, R
    5 is a phenylalkyl radical, n is equal to 1, 2 or 3, m is equal to 0, 1, 2 or 3. The present invention also relates to the salts of said compounds, processes for the preparation of the latter and drugs containing them.

    摘要翻译： PCT No.PCT / FR91 / 00437 Sec。 371日期1992年12月2日 102（e）日期1992年12月2日PCT提交1991年5月31日PCT公布。 WO91 / 18892 PCT出版物 （I）式（I）化合物，其中R 1是多氟烷氧基，R 2是被烷基或磺酰基或亚磺酰基取代的硫或氮原子，R 3是苯基 ，苯甲酰基，-NR4R5或哌啶基-4-取代的苯基烷基，R4为烷基，R5为苯基烷基，n等于1,2或3，m等于0,1,2或 本发明还涉及所述化合物的盐，其制备方法和含有它们的药物。

    Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them
    78.
    发明授权
    Derivatives of (AZA)naphthalenesultam, their preparation and compositions containing them 失效

    公开(公告)号：US5021420A

    公开(公告)日：1991-06-04

    申请号：US375934

    申请日：1989-07-06

    申请人： Marie-Iherese Comte ,  Claude Gueremy ,  Jean-Luc Malleron ,  Serge Mignani ,  Jean-Francois Peyronel ,  Alain Truchon

    发明人： Marie-Iherese Comte ,  Claude Gueremy ,  Jean-Luc Malleron ,  Serge Mignani ,  Jean-Francois Peyronel ,  Alain Truchon

    IPC分类号： A61K31/425 ,  A61K31/428 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/54 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P43/00 ,  C07D275/06 ,  C07D417/00 ,  C07D417/06 ,  C07D417/14 ,  C07D513/06

    CPC分类号： C07D275/06 ,  C07D417/06 ,  C07D417/14 ,  C07D513/06

    摘要： This invention relates to a compound ##STR1## in which R.sub.1 representsa 1,2,3,6-tetrahydro-1-pyridyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxy or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical.a 1-piperazinyl radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxy, nitro or amino radical or a halogen atom, (c) a 1,2-benzisothiazol-3-yl radical, (d) a 1,2-benzisoxazol-3-yl radical or (e) a 2-pyridyl radical.a piperidino radical substituted in the 4-position by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or a hydroxy, alkyl or alkoxy radical, (c) two phenyl radicals, (d) a bis(4-fluorophenyl)methylene radical, (e) a 4-fluorobenzoyl radical, (f) a 2-oxo-1-benzimidazolinyl radical, (g) a 2-oxo-1-benzimidazolinyl radical substituted in the 3-position by an alkylcarbonyl or benzoyl radical, (b) a hydroxy radical and a phenyl radical optionally substituted with an alkyl, alkoxy or hydroxy radical or a halogen atom, (i) a 3-indolyl radical, (j) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in the 5-position by a halogen atom or (k) a 3-(5-hydroxyindolyl) radical.either:R.sub.2 and R.sub.3, which are identical, represent a hydrogen or halogen atom and R.sub.4 represents a hydrogen atom orR.sub.2 and R.sub.4 represent a hydrogen atom and R.sub.3 represents a halogen atom or an acetylamino radical orR.sub.2 and R.sub.3 represent a hydrogen atom and R.sub.4 represents a halogen atom and R.sub.5 represents a --CH.dbd. group.or R.sub.2, R.sub.3 and R.sub.4 represent a hydrogen atom and R.sub.5 represents a nitrogen atom.R.sub.6 represents an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in the 1- or 3-position by an alkyl radical or in the 2-position by an alkyl, alkoxy, hydroxy, dialkylamino, piperidino, morpholino or thiomorpholino radical,with the reservation that when R.sub.6 represents a propylene radical substituted in the 2-position by a dialkylamino, piperidino, morpholino or thiomorpholino radical, R.sub.1 cannot be a radical containing a hydroxy radical, and their salts, are useful in therapy for their ability to block serotonin receptors.