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1.发明申请公开(公告)号：US20120053209A1
公开(公告)日：2012-03-01
申请号：US13258921
申请日：2010-03-18
Applicant: Jerome Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Samir Jegham , Sandrine Hilairet
Inventor： Jerome Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Samir Jegham , Sandrine Hilairet
IPC: A61K31/444 , A61P35/00 , C07D401/12
CPC classification number: C07D401/12 , C07D213/56
Abstract: The invention relates to nicotinamide derivatives that can be used as anticancer drugs.
Abstract translation: 本发明涉及可用作抗癌药物的烟酰胺衍生物。
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2.发明申请2-ANILINO-4-HETEROARYL PYRIMIDINE DERIVATIVES, AND PREPARATION THEREOF AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS, AND IN PARTICULAR IKK INHIBITORS 审中-公开2-苯胺-4-异喹啉衍生物及其作为药物，药物组合物和特定IKK抑制剂的制剂公开(公告)号：US20100099694A1
公开(公告)日：2010-04-22
申请号：US12496107
申请日：2009-07-01
Applicant: Didier BABIN , Monsif BOUABOULA , Pierre CASELLAS , Serge MIGNANI , Jean-Flaubert NGUEFACK , Jean WAGNON
Inventor： Didier BABIN , Monsif BOUABOULA , Pierre CASELLAS , Serge MIGNANI , Jean-Flaubert NGUEFACK , Jean WAGNON
IPC: A61K31/506 , C07D401/14 , C12N9/99 , A61P29/00 , A61P3/10 , A61P35/00
CPC classification number: C07D401/14
Abstract: The disclosure relates to a compound of formula (I): wherein R, R2, R3, R4, R5, z, D and W are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.
Abstract translation: 本公开涉及式（I）化合物：其中R，R 2，R 3，R 4，R 5，Z，D和W如说明书中所定义，含有它们的组合物，其制备方法及其用途 在治疗或预防能够通过抑制蛋白激酶活性调节的条件下进行。
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3.发明申请NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开NICOTINAMIDE衍生物，其制剂及其治疗用途公开(公告)号：US20100222319A1
公开(公告)日：2010-09-02
申请号：US12732749
申请日：2010-03-26
Applicant: Claude BERNHART , Monsif BOUABOULA , Pierre CASELLAS , Samir JEGHAM , Jèrome ARIGON , Romain COMBET , Sandrine HILAIRET , Pierre FRAISSE
Inventor： Claude BERNHART , Monsif BOUABOULA , Pierre CASELLAS , Samir JEGHAM , Jèrome ARIGON , Romain COMBET , Sandrine HILAIRET , Pierre FRAISSE
IPC: A61K31/4545 , A61P35/00 , C07F5/02 , C07D401/12 , A61K31/444 , C07D401/14 , A61K31/496 , C07D417/14 , A61K31/541 , C07D413/14 , A61K31/5377 , A61K31/55
CPC classification number: C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14
Abstract: The disclosure relates to compounds of formula (I): wherein A, Z, Z′, L, R2 and R3 are as defined in the disclosure, to compositions comprising said compounds, and to methods for the manufacture and therapeutic use thereof.
Abstract translation: 本公开涉及式（I）化合物：其中A，Z，Z'，L，R 2和R 3如本公开所定义，包含所述化合物的组合物，以及其制备和治疗用途的方法。
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4.发明申请NEW 2,4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF ESSENTIALLY AS IKK INHIBITORS 审中-公开新的2,4-二氨基嘧啶，其作为药物，药物组合物的制备及其作为IKK抑制剂的用途公开(公告)号：US20100035907A1
公开(公告)日：2010-02-11
申请号：US12495992
申请日：2009-07-01
Applicant: Monsif BOUABOULA , Michael BOSCH , Pierre CASELLAS , Jean-Flaubert Nguefack , Bernard Tonnerre , Jean Wagnon
Inventor： Monsif BOUABOULA , Michael BOSCH , Pierre CASELLAS , Jean-Flaubert Nguefack , Bernard Tonnerre , Jean Wagnon
IPC: A61K31/506 , C07D239/12 , C07D401/12 , A61P35/00 , A61P3/10
CPC classification number: C07D401/12 , C07D405/12 , C07D417/14 , C07D471/04
Abstract: The disclosure relates to a compound of formula (I): wherein R1, R2, R3, R4, R5, A and Y are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.
Abstract translation: 本公开涉及式（I）化合物：其中R1，R2，R3，R4，R5，A和Y如说明书中所定义，含有它们的组合物，其制备方法及其在 治疗或预防能够通过抑制蛋白激酶的活性来调节的条件。
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5.发明申请公开(公告)号：US20120094986A1
公开(公告)日：2012-04-19
申请号：US13258847
申请日：2010-03-22
Applicant: Jérôme Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Sandrine Hilairet , Samir Jegham
Inventor： Jérôme Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Sandrine Hilairet , Samir Jegham
IPC: A61K31/444 , C07D417/14 , A61P35/00 , C07D401/14 , A61K31/4545 , C07D401/12 , A61K31/541
CPC classification number: C07D213/82 , C07D417/14
Abstract: The invention relates to nicotinamide derivatives which can be used as anticancer drugs.
Abstract translation: 本发明涉及可用作抗癌药物的烟酰胺衍生物。
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Patent Agency Ranking
6.发明申请NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF AS ANTICANCER DRUGS 审中-公开尼古丁衍生物，其制剂及其作为抗感染药物的治疗用途公开(公告)号：US20120053170A1
公开(公告)日：2012-03-01
申请号：US13258220
申请日：2010-03-22
Applicant: Jérome Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Sandrine Hilairet , Samir Jegham
Inventor： Jérome Arigon , Claude Bernhart , Monsif Bouaboula , Romain Combet , Sandrine Hilairet , Samir Jegham
IPC: A61K31/55 , C07D417/14 , C07D401/12 , C07F5/02 , C07F5/04 , C07D239/42 , C07D213/82 , C07D239/30 , A61K31/4545 , A61K31/506 , A61K31/541 , A61K31/444 , A61K31/496 , A61P35/00 , C07D401/14
CPC classification number: C07D401/12 , C07D213/79 , C07D213/82 , C07D239/42 , C07D401/14 , C07D417/12
Abstract: The present invention relates to nicotinamide derivatives of formula (I), to compositions containing same, and to the therapeutic use thereof, in particular as anticancer drugs. The invention also relates to the method for preparing said compounds, as well as to some of the intermediate products.
Abstract translation: 本发明涉及式（I）的烟酰胺衍生物，含有其的组合物及其治疗用途，特别是作为抗癌药物。 本发明还涉及制备所述化合物的方法以及一些中间产物。
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7.发明申请ANTINEOPLASTIC DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF 审中-公开抗生素衍生物，其制备方法及其治疗方法公开(公告)号：US20110251194A1
公开(公告)日：2011-10-13
申请号：US12986642
申请日：2011-01-07
Applicant: Claude BERNHART , Gary MCCORT , Samir JEGHAM , Jean Marc HERBERT , Pierre CASELLAS , Monsif BOUABOULA , Olivier DUCLOS
Inventor： Claude BERNHART , Gary MCCORT , Samir JEGHAM , Jean Marc HERBERT , Pierre CASELLAS , Monsif BOUABOULA , Olivier DUCLOS
IPC: A61K31/496 , C07D401/02 , A61K31/5377 , A61K31/4709 , A61P35/00 , C07D471/04 , A61K31/444
CPC classification number: C07D471/04 , C07D401/12 , C07D401/14 , C07D407/14
Abstract: The disclosure concerns heterobicyclic compounds of general formula (I) and acid addition salts, hydrates and solvates thereof, as well as enantiomers, diastereoisomers and mixtures thereof. Methods for preparing the compounds, pharmaceutical compositions, and methods of treatment also are disclosed.
Abstract translation: 本公开涉及通式（I）的杂双环化合物及其酸加成盐，水合物和溶剂合物，以及对映异构体，非对映异构体及其混合物。 还公开了制备化合物的方法，药物组合物和治疗方法。
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8.发明申请N,N'-2,4-DIANILINOPYRIMIDINE DERIVATIVES, PREPARATION THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS ESSENTIALLY AS IKK INHIBITORS 审中-公开N，N'-2,4-二氨基吡啶衍生物，其作为药物的制剂，基本上作为IKK抑制剂的药物组合物公开(公告)号：US20100093668A1
公开(公告)日：2010-04-15
申请号：US12495998
申请日：2009-07-01
Applicant: Didier BABIN , Monsif BOUABOULA , Pierre CASELLAS , Maria MENDEZ-PEREZ , Serge MIGNANI , Jean-Flaubert NGUEFACK , Jacob-Alsboek OLSEN , Bernard TONNERRE , Jean WAGNON
Inventor： Didier BABIN , Monsif BOUABOULA , Pierre CASELLAS , Maria MENDEZ-PEREZ , Serge MIGNANI , Jean-Flaubert NGUEFACK , Jacob-Alsboek OLSEN , Bernard TONNERRE , Jean WAGNON
IPC: C07D401/12 , A61K31/506 , A61K31/675 , A61K31/497 , C07D403/12 , C07D413/12 , A61K31/5355 , C12N9/99 , A61P35/04
CPC classification number: C07D417/14 , C07D209/10 , C07D211/58 , C07D213/24 , C07D231/12 , C07D239/42 , C07D277/22 , C07D285/06 , C07D285/14 , C07D333/06 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/14 , C07D409/14 , C07D413/14
Abstract: The disclosure relates to a compound of formula (I): wherein R, R1, R2, R3, R4, R5, R6 and Z are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.
Abstract translation: 本公开涉及式（I）化合物：其中R，R 1，R 2，R 3，R 4，R 5，R 6和Z如说明书中所定义，含有它们的组合物，其制备方法及其用途 在治疗或预防能够通过抑制蛋白激酶活性调节的条件下进行。
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9.发明申请NOVEL PHENYL(4-PHENYLPYRIMIDIN-2-YL)AMINE DERIVATIVES, THEIR PREPARATION, AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS 审中-公开新型苯基（4-苯基嘧啶-2-基）胺衍生物，其制备，作为药物，药物组合物，特别是IKK抑制剂公开(公告)号：US20100069417A1
公开(公告)日：2010-03-18
申请号：US12496105
申请日：2009-07-01
Applicant: Monsif BOUABOULA , Pierre CASELLAS , Sherri DUDAL , Regine FLOUTARD , Maria MENDEZ-PEREZ , Jean-Flaubert NGUEFACK , Jacob-Alsboek OLSEN , Bernard TONNERRE , Jean WAGNON
Inventor： Monsif BOUABOULA , Pierre CASELLAS , Sherri DUDAL , Regine FLOUTARD , Maria MENDEZ-PEREZ , Jean-Flaubert NGUEFACK , Jacob-Alsboek OLSEN , Bernard TONNERRE , Jean WAGNON
IPC: A61K31/506 , C07D401/12 , C07D401/14 , C07D409/14 , C07D417/14 , A61P29/00 , A61P3/10 , A61P35/00
CPC classification number: C07D211/58 , C07D213/06 , C07D233/56 , C07D237/04 , C07D239/42 , C07D277/22 , C07D307/78 , C07D333/06 , C07D401/12 , C07D401/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D417/14
Abstract: The disclosure relates to a compound of formula (I): wherein R, R2, R3, R4, R5, Z, W and D are as defined in the specification, to compositions containing them, to processes for preparing them, and to their use in the treatment or prevention of conditions capable of being modulated by the inhibition of the activity of protein kinases.
Abstract translation: 本公开涉及式（I）化合物：其中R，R2，R3，R4，R5，Z，W和D如说明书中所定义，含有它们的组合物，其制备方法及其用途 在治疗或预防能够通过抑制蛋白激酶活性调节的条件下进行。
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10.发明申请Novel 2,4-Dianilinopyrimidine Derivatives, the Preparation Thereof, Their Use as Medicaments, Pharmaceutical Compositions and, in Particular, as IKK Inhibitors 审中-公开新型2,4-Dianilinopyrimidine衍生物，其制备方法，用作药物，药物组合物，特别是作为IKK抑制剂公开(公告)号：US20080269170A1
公开(公告)日：2008-10-30
申请号：US11971389
申请日：2008-01-09
Applicant: Michael Bosch , Monsif Bouaboula , Pierre Casellas , Samir Jegham , Serge Mignani , Jean-Flaubert Nguefack , Jacob-Alsboek Olsen , Bernard Tonnerre , Jean Wagnon
Inventor： Michael Bosch , Monsif Bouaboula , Pierre Casellas , Samir Jegham , Serge Mignani , Jean-Flaubert Nguefack , Jacob-Alsboek Olsen , Bernard Tonnerre , Jean Wagnon
IPC: C07D403/02 , C07D401/02 , A61K31/397 , A61K31/506 , A61K31/505 , A61P3/10 , A61P37/00 , A61P35/00
CPC classification number: C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/08 , C07D471/14 , C07F9/65583
Abstract: The disclosure relates to compounds of formula (I): wherein R1-R5, A and Y are as defined in the disclosure, to compositions comprising said compounds, and to processes for making and methods of using the same.
Abstract translation: 本公开涉及式（I）化合物：其中R1-R5，A和Y如本公开所定义，包含所述化合物的组合物，以及其制备方法和使用该化合物的方法。
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