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113 条记录 (耗时 0.032 秒)

    Human EP3 prostaglandin receptor
    75.
    发明授权
    Human EP3 prostaglandin receptor 失效
    人EP3前列腺素受体

    公开(公告)号：US06670134B1

    公开(公告)日：2003-12-30

    申请号：US09661758

    申请日：2000-09-14

    申请人： Daniel W. Gil ,  John W. Regan

    发明人： Daniel W. Gil ,  John W. Regan

    IPC分类号： G01N3353

    CPC分类号： G01N33/88 ,  C07K14/72 ,  C07K16/2869

    摘要： A gene encoding the human EP3 prostaglandin receptor has been cloned and sequenced. The protein encoded by this gene has seven transmembrane domains and is 81% homologous to the murine EP3 receptor. Two variants that differ in their carboxy terminal coding sequence, and one variant that differs in its 3′ untranslated sequence only, have also been cloned. The proteins, when expressed in eukaryotic cells, are capable of binding prostaglandins and their agonists and regulating adenylate cyclase activity in response to prostaglandins.

    摘要翻译： 编码人EP3前列腺素受体的基因已被克隆并测序。 由该基因编码的蛋白具有7个跨膜结构域，与鼠EP3受体81％同源。 它们的羧基末端编码序列不同的两个变体和仅在其3'非翻译序列中不同的一个变体也被克隆。 当在真核细胞中表达时，蛋白质能够结合前列腺素及其激动剂并且响应于前列腺素调节腺苷酸环化酶活性。

    Methods of preventing and reducing the severity of stress-associated conditions
    79.
    发明授权
    Methods of preventing and reducing the severity of stress-associated conditions 有权
    预防和减轻压力相关病症严重程度的方法

    公开(公告)号：US07977335B2

    公开(公告)日：2011-07-12

    申请号：US12114727

    申请日：2008-05-02

    申请人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    发明人： Daniel W. Gil ,  Scott Whitcup ,  Mitchell F. Brin ,  John E. Donello

    IPC分类号： A61K31/198

    CPC分类号： A61K31/498

    摘要： The present invention provides a method of preventing or reducing the severity of a stress-associated condition in a subject by systemically administering to the subject an effective amount of brimonidine or a pharmaceutically acceptable salt, ester, amide, stereoisomer or racemic mixture thereof. Stress-associated conditions that can be treated according to a method of the invention include, but are not limited to, dyspepsia, tachycardias other than tachycardia associated with myocardial ischemia, panic attack, non-inflammatory dermatological conditions, disorders of muscle contraction, sensory hypersensitivity associated with migraine, and behavioral disorders.

    摘要翻译： 本发明提供了通过向受试者全身施用有效量的溴莫尼定或其药学上可接受的盐，酯，酰胺，立体异构体或外消旋混合物来提供预防或减轻受试者的应激相关状况的严重性的方法。 可以根据本发明的方法治疗的应激相关病症包括但不限于消化不良，与心肌缺血相关的心动过速以外的心动过速，惊恐发作，非炎性皮肤病学条件，肌肉收缩障碍，感觉超敏反应 与偏头痛和行为障碍相关。