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    Charging stand
    71.
    外观设计
    Charging stand 有权

    公开(公告)号：USD968323S1

    公开(公告)日：2022-11-01

    申请号：US29790728

    申请日：2021-12-13

    Applicant: Li Wang

    Designer： Li Wang

    DNA polymerase mutants with increased processivity of DNA synthesis
    73.
    发明授权
    DNA polymerase mutants with increased processivity of DNA synthesis 有权

    公开(公告)号：US10704031B2

    公开(公告)日：2020-07-07

    申请号：US16198773

    申请日：2018-11-22

    Applicant: Jing Wu ,  Li Wang

    Inventor： Jing Wu ,  Li Wang

    IPC: C12N9/12 ,  C12N15/52 ,  C12N15/63 ,  C12P19/34

    Abstract: Disclosed are Dpo4 DNA polymerase mutants with increased DNA synthesis processivity. The mutant enzymes, Dpo4 A181D and Dpo4 E63K, are constructed based on the wild-type Dpo4 derived from Sulfolobus solfataricus to obtain Dpo4DNA polymerase mutants with increased DNA processivity. The extension length of Dpo4 A181D and Dpo4 E63K are respectively increased by 25% and 18.8% than that of the wild-type Dpo4. The fidelity of Dpo4 A181D and wild-type Dpo4 are similar, and the fidelity of Dpo4 E63K is increased from that of the wild-type Dpo4. In summary, the mutants Dpo4 A181D and Dpo4 E63K obtained by the present invention have increased processivity compared to that of the wild-type Dpo4 DNA polymerase.

    HEAT EXCHANGE DEVICE SUITABLE FOR LOW PRESSURE REFRIGERANT
    74.
    发明申请
    HEAT EXCHANGE DEVICE SUITABLE FOR LOW PRESSURE REFRIGERANT 审中-公开

    公开(公告)号：US20190086128A1

    公开(公告)日：2019-03-21

    申请号：US16081007

    申请日：2017-02-28

    Applicant: Xiuping Su ,  Li Wang ,  Johnson Controls Technology Company

    Inventor： Xiuping Su ,  Li Wang

    IPC: F25B39/00 ,  F25B1/06

    Abstract: Embodiments of the present disclosure are directed to a heat exchange device that includes a condenser configured to receive a refrigerant, an evaporator having an evaporation tube bundle, a throttling device configured to receive a first portion of the refrigerant from the condenser and to expand the first portion of the refrigerant before directing the first portion to the evaporator, and an ejector having a high pressure conduit, a low pressure conduit, and an outlet conduit, the ejector is configured to receive the first portion from the throttling device or a second portion of the refrigerant from the condenser via the high pressure conduit, receive a third portion of the refrigerant from the evaporator via the low pressure conduit, mix the first portion or the second portion with the third portion to form a mixed refrigerant, and direct the mixed refrigerant to the evaporator via the outlet conduit.

    Monitoring an interval within the cardiac cycle
    75.
    发明授权
    Monitoring an interval within the cardiac cycle 有权
    监测心脏周期内的间隔

    公开(公告)号：US09538922B2

    公开(公告)日：2017-01-10

    申请号：US12609700

    申请日：2009-10-30

    Applicant: Li Wang

    Inventor： Li Wang

    IPC: A61B5/02 ,  A61B5/024 ,  A61B5/0245 ,  A61B5/0452 ,  A61N1/37 ,  A61N1/372 ,  A61B5/00 ,  A61N1/362

    CPC classification number: A61B5/024 ,  A61B5/0245 ,  A61B5/0452 ,  A61B5/7285 ,  A61N1/3627 ,  A61N1/3702 ,  A61N1/37258

    Abstract: Aspects of this disclosure describe measuring intervals within a cardiac cycle to, for example, determine whether a patient is a candidate for cardiac therapy initiation or modification. The intervals may be measured in response to a trigger identifying a physiological event. The intervals and an identification of the physiological event may be stored. A physician or clinician may determine whether the patient is a candidate for cardiac therapy modification based on the measured intervals.

    Abstract translation: 本公开的方面描述了心脏周期内的测量间隔，以例如确定患者是否是心脏治疗开始或修改的候选者。 可以响应于识别生理事件的触发来测量间隔。 可以存储生理事件的间隔和识别。 医生或临床医生可以基于测量的间隔来确定患者是否是心脏修复的候选者。

    Regulatory T cell mediator proteins and uses thereof
    78.
    发明授权
    Regulatory T cell mediator proteins and uses thereof 有权
    调节性T细胞介质蛋白及其用途

    公开(公告)号：US09217035B2

    公开(公告)日：2015-12-22

    申请号：US13901704

    申请日：2013-05-24

    Applicant: Randolph J. Noelle ,  Li Wang

    Inventor： Randolph J. Noelle ,  Li Wang

    IPC: A61K38/00 ,  C07K14/705 ,  C07K16/28 ,  G01N33/50 ,  A61K39/00

    CPC classification number: C07K16/2827 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/70596 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/505 ,  Y02A50/412 ,  Y02A50/423

    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates αCD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon αCD3/αGITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. multiple sclerosis is disclosed.

    Abstract translation: 本发明涉及新型调节性T细胞蛋白。 称为PD-L3的一种蛋白质类似于PD-L1家族的成员，并且在体外共同刺激T细胞的αCD3增殖。 第二种TNF样蛋白也被鉴定为在αCD3/αGITR刺激下上调。 该蛋白质已被命名为Treg-sTNF。 公开了蛋白质，抗体，活化的T细胞及其使用方法。 特别是使用这些蛋白质和化合物（优选抗体）的方法，其结合或调节（激动或拮抗）这些蛋白质的活性，作为免疫调节剂和用于治疗癌症，自身免疫疾病，变态反应，感染和炎性病症，例如， 公开了多发性硬化。

    High exchange capacity perfluorinated ion exchange resin, preparation method and use thereof
    80.
    发明授权
    High exchange capacity perfluorinated ion exchange resin, preparation method and use thereof 有权
    高交换能力的全氟化离子交换树脂，其制备方法和用途

    公开(公告)号：US09090723B2

    公开(公告)日：2015-07-28

    申请号：US13516691

    申请日：2009-12-15

    Applicant: Yongming Zhang ,  Heng Zhang ,  Sheng Qin ,  Zihong Gao ,  Li Wang ,  Yong Li ,  Xuezhang Song

    Inventor： Yongming Zhang ,  Heng Zhang ,  Sheng Qin ,  Zihong Gao ,  Li Wang ,  Yong Li ,  Xuezhang Song

    IPC: H01M8/10 ,  C08F214/26 ,  C25B13/08 ,  C08J5/22

    CPC classification number: C08F214/265 ,  C08F214/26 ,  C08F214/262 ,  C08F214/267 ,  C08J5/2243 ,  C08J2327/12 ,  H01M8/1023 ,  H01M8/1039 ,  H01M2008/1095 ,  Y02E60/522

    Abstract: The present invention provides a high exchange capacity perfluorinated resin comprising two kinds of sulfonyl fluoride-containing short pendant groups of different structures, which is prepared by copolymerizing tetrafluoroethylene, vinyl ether monomers comprising two kinds of sulfonyl fluoride-containing short pendant groups of different structures, and vinyl ether monomer comprising bromine-containing pendant group, wherein based on all monomer units in the copolymer, the mol % of tetrafluoroethylene monomer is 50-85%, the mol % of vinyl ether monomers comprising two kinds of sulfonyl fluoride-containing short pendant groups of different structures is 5-49% and the mol % of vinyl ether monomer comprising bromine-containing pendant group is 1-10%. Perfluorinated ion exchanges membrane prepared from such perfluorinated resin have resistance to various chemical media, high ion exchange capacity, high conductivity, high mechanical strength, high size stability, low membrane electrical resistance and long service life, and may be applied in fuel cells or high-temperature fuel cells.

    Abstract translation: 本发明提供一种高交换能力的全氟化树脂，其包含两种不同结构的含磺酰氟的短侧基，其通过共聚四氟乙烯，包含两种不同结构的含磺酰氟的短侧基的乙烯基醚单体制备， 和含溴侧基的乙烯基醚单体，其中，基于共聚物中的所有单体单元，四氟乙烯单体的摩尔％为50-85％，包含两种含磺酰氟的短侧基的乙烯基醚单体的摩尔％ 不同结构的基团为5-49％，包含含溴侧基的乙烯基醚单体的摩尔％为1-10％。 由这种全氟化树脂制备的全氟化离子交换膜具有耐各种化学介质，高离子交换能力，高导电性，高机械强度，高尺寸稳定性，低膜电阻，使用寿命长等优点，可用于燃料电池或高 燃料电池。

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