公开(公告)号：US20240027456A1

公开(公告)日：2024-01-25

申请号：US18376575

申请日：2023-10-04

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin ,  Srikant Vaithilingam

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11802877B2

公开(公告)日：2023-10-31

申请号：US16883468

申请日：2020-05-26

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin ,  Srikant Vaithilingam

IPC: G01N33/574

CPC classification number: G01N33/57423 ,  G01N2800/52

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20220299514A1

公开(公告)日：2022-09-22

申请号：US17667714

申请日：2022-02-09

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  A61K31/5377 ,  C12Q1/42 ,  C12Q1/48

Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen, The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11327076B2

公开(公告)日：2022-05-10

申请号：US16157341

申请日：2018-10-11

Applicant: Meso Scale Technologies, LLC.

Inventor： Simone Barbero ,  Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  A61K31/5377 ,  C12Q1/42 ,  C12Q1/48

Abstract: The present invention relates to methods of diagnosing breast cancer in a patient, as well as methods of monitoring the progression of breast cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US20210373033A1

公开(公告)日：2021-12-02

申请号：US17169805

申请日：2021-02-08

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  John Kenten ,  Galina Nikolenko

IPC: G01N33/68

Abstract: The present invention relates to methods of diagnosing glomerulonephritis (GN) in a patient, as well as methods of monitoring the progression of GN and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11135594B2

公开(公告)日：2021-10-05

申请号：US16292521

申请日：2019-03-05

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Kenneth Page ,  Sandor Kovacs ,  Sudeep Kumar ,  Kristian Roth

IPC: B01L3/00 ,  F16K11/074

Abstract: Assay cartridges are described that have a plurality of chambers and a fluidic network that includes fluidic conduits and a multi-port valve designed to selectively connect the valve inlet and one valve outlet through a fluidic connector in the valve as the remaining valve outlets are sealed.

公开(公告)号：US11105799B2

公开(公告)日：2021-08-31

申请号：US15813411

申请日：2017-11-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Anu Mathew

IPC: G01N33/574 ,  G01N33/543

Abstract: The present invention relates to methods of diagnosing a kidney disorder in a patient, as well as methods of monitoring the progression of a kidney disorder and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.

公开(公告)号：US11065615B2

公开(公告)日：2021-07-20

申请号：US15882914

申请日：2018-01-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20210172937A1

公开(公告)日：2021-06-10

申请号：US17026561

申请日：2020-09-21

Applicant: Meso Scale Technologies, LLC.

Inventor： Eli N. Glezer ,  Kent Johnson ,  Michael Tsionsky ,  John H. Kenten ,  Jeff D. Debad ,  Robert M. Umek ,  Paula Denney Eason ,  Hans Biebuyck ,  Jacob N. Wohlstadter ,  James Wilbur ,  George Sigal ,  Niranjan Y. Sardesai

IPC: G01N33/53 ,  C12Q1/48 ,  G01N33/543 ,  G01N33/68 ,  G01N33/569 ,  G01N33/573

Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.

公开(公告)号：US20210116452A1

公开(公告)日：2021-04-22

申请号：US16883468

申请日：2020-05-26

Applicant: Meso Scale Technologies, LLC.

Inventor： Anahit Aghvanyan ,  Eli N. Glezer ,  John Kenten ,  Sudeep Kumar ,  Galina Nikolenko ,  Martin Stengelin ,  Srikant Vaithilingam

IPC: G01N33/574

Abstract: The present invention relates to methods of diagnosing lung cancer in a patient, as well as methods of monitoring the progression of lung cancer and/or methods of monitoring a treatment protocol of a therapeutic agent or a therapeutic regimen. The invention also relates to assay methods used in connection with the diagnostic methods described herein.