公开(公告)号：US09804173B2

公开(公告)日：2017-10-31

申请号：US14478221

申请日：2014-09-05

Applicant: Meso Scale Technologies, LLC

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

CPC classification number: G01N33/6893 ,  G01N33/6863 ,  G01N2333/523 ,  G01N2333/525 ,  G01N2333/70578 ,  G01N2800/065 ,  G01N2800/52

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US11065615B2

公开(公告)日：2021-07-20

申请号：US15882914

申请日：2018-01-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20180017578A1

公开(公告)日：2018-01-18

申请号：US15716743

申请日：2017-09-27

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US11892455B2

公开(公告)日：2024-02-06

申请号：US17061095

申请日：2020-10-01

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC: G01N35/10 ,  B67B7/00 ,  G01N33/58 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/02 ,  B01L3/00 ,  G01N35/04

CPC classification number: G01N33/582 ,  B01L3/5085 ,  B01L3/50255 ,  B67B7/24 ,  G01N21/6452 ,  G01N21/66 ,  G01N33/5302 ,  G01N35/028 ,  G01N35/1011 ,  G01N35/1079 ,  G01N35/1081 ,  G01N35/1002 ,  G01N35/109 ,  G01N2035/0405 ,  G01N2035/0425 ,  G01N2035/1025 ,  Y10T83/9314

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US20210339243A1

公开(公告)日：2021-11-04

申请号：US17378294

申请日：2021-07-16

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. GLEZER ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Bisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/53

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.

公开(公告)号：US20200309790A1

公开(公告)日：2020-10-01

申请号：US16901294

申请日：2020-06-15

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US11300571B2

公开(公告)日：2022-04-12

申请号：US16420724

申请日：2019-05-23

Applicant: Meso Scale Technologies, LLC

Inventor： Charles M. Clinton ,  Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Sandor L. Kovacs ,  Sudeep M. Kumar ,  George Sigal ,  Carl Stevens ,  Michael Vock

IPC: B01L3/00 ,  G01N35/02 ,  G01N33/58 ,  B67B7/00 ,  G01N35/10 ,  G01N21/64 ,  G01N21/66 ,  G01N33/53 ,  G01N35/04

Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.

公开(公告)号：US10712351B2

公开(公告)日：2020-07-14

申请号：US15716743

申请日：2017-09-27

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US20230038393A1

公开(公告)日：2023-02-09

申请号：US17720956

申请日：2022-04-14

Applicant: Meso Scale Technologies, LLC.

Inventor： Jeff D. Debad ,  Eli N. Glezer ,  Sudeep M. Kumar

IPC: G01N33/68

Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient’s treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.

公开(公告)号：US09878323B2

公开(公告)日：2018-01-30

申请号：US13662553

申请日：2012-10-29

Applicant: MESO SCALE TECHNOLOGIES, LLC

Inventor： Eli N. Glezer ,  Bandele Jeffrey-Coker ,  Jeffery D. Debad ,  Sudeep M. Kumar ,  George B. Sigal ,  Gisbert Spieles ,  Michael Tsionsky ,  Michael Warnock

IPC: C12Q1/00 ,  B01L3/00 ,  G01N33/543

CPC classification number: B01L3/5025 ,  B01L3/5085 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0645 ,  B01L2300/0829 ,  B01L2300/0851 ,  B01L2300/0858 ,  B01L2300/105 ,  G01N33/54366 ,  G01N33/54393 ,  Y10S436/809

Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.