摘要:
The invention relates to the analgesic compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, Z and m are as defined in the description, their isomers, epimers and diastereoisomers, their addition salts with a pharmaceutically acceptable acid and, when R.sub.1 and R.sub.2 each represent a hydrogen atom, their addition salts with a pharmaceutically acceptable base.
摘要:
In a deasphalting process wherein the deasphalted oil is separated from the deasphalting solvent, the invention consists of performing said separation in at least two separate steps, differing by their temperatures, and of recovering heat from the deasphalted oil.The oil to be deasphalted (26) passes through an extractor (1), then through heat recuperators (3) and (4). The oil-solvent separation is achieved in two steps (5) and (11), under supercritical conditions, at different temperatures. The process has the particular advantage of saving power since external heat is provided (10) to only part of the charge.
摘要:
The hydrotreatment of hydrocarbons in the liquid phase is effected in a column containing a catalyst bed supported by a grid, wherethrough passes an ascending stream of the charge admixed with hydrogen which expands the catalyst bed, the perforations of the grid being small enough to prevent passage of the catalyst particles but large enough to permit passage of the hydrogen-charge mixture, the reaction effluent being withdrawn from the top of the column.
摘要:
A continuous process is provided for the preparation of a maleamic acid of the formula: ##STR1## in which: R represents a linear or branched alkylene, arylene, aralkylene, alkylarylene or cycloalkylene radical or a divalent heterocyclic radical, the free valencies of which are attached to carbon atoms, the radical containing 2 to 20 carbon atoms and X represents either a hydrogen atom or the radical: ##STR2## which comprises passing a solution of a primary monoamine or diamine and a solution of maleic anhydride in amounts such that there is a 5 to 20 mol % excess of anhydride, at a temperature of from 40.degree. to 130.degree. C and at a rate greater than 7 m/second through an injection nozzle into a twin screw reactor, the solvent for the primary amine being the same as, or compatible with, the solvent for the maleic anhydride. This process eliminates clogging problems.
摘要:
The invention relatests compound of formula (I): wherein: n is 1, 2 or 3, A represents a group or a group X represents N or NR1, R2 represents an alkoxy, cycloalkyloxy or cycloalkylalkyloxy group. and medicinal products containing the same which are useful in treading or in preventing melatoninergic disorder.
摘要:
Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR′ and SO2NHR′ wherein R′ represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.
摘要:
Compounds of formula (I): wherein: X represents oxygen or sulphur or a group CH2 or R1, R2, R3, R4, R5 and R6 are as defined in the description, A represents an alkylene chain as defined in the description, B represents alkyl or alkenyl substituted by a group or R9, or B represents a group or R9, D represents a benzene, pyridine, pyrazine, pyrimidine or pyridazine nucleus. Medicaments
摘要:
The invention relates to compounds of formula (I): wherein: A represents R3 represents alkoxy, R4 is as defined in the description, p is 1, 2 or 3, and medicinal products containing the same which are useful in treating or preventing melatoninergic disorders.
摘要:
A method of manufacturing an anisotropic conductive polymer film on a semiconductor wafer including on one surface a layer of passivation in which at least one opening is made to allow access to a contact pad. The method can be applied to creating components (chips, integrated circuits) with high-density interconnections.
摘要:
Compounds of formula (I): wherein: R1 represents an optionally substituted heteroaryl group, R2 represents an optionally substituted cycloalkyl group, R3 represents a hydrogen atom or an alkyl group, and R4 and R5 are as defined in the description, and Medicinal products containing the same are useful in the treatment of non-insulin-dependent type II diabetes, obesity, type I diabetes, hyperlipidaemia, hypercholesterolaemia and cardiovascular complications thereof.