公开(公告)号：US07371822B2

公开(公告)日：2008-05-13

申请号：US11377517

申请日：2006-03-16

申请人： Chandra S. Ramanathan ,  John N. Feder

发明人： Chandra S. Ramanathan ,  John N. Feder

IPC分类号： C07K14/705

CPC分类号： C07K14/705

摘要： The present invention provides novel polynucleotides encoding HGPRBMY74 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing these polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY74 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY74多肽，其片段和同源物的新型多核苷酸。 还提供了载体，宿主细胞，抗体以及用于产生这些多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY74多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07312086B2

公开(公告)日：2007-12-25

申请号：US10375157

申请日：2003-02-26

申请人： John N. Feder ,  Thomas C. Nelson ,  Chandra S. Ramanathan ,  Rolf-Peter Ryseck ,  Michael G. Neubauer

发明人： John N. Feder ,  Thomas C. Nelson ,  Chandra S. Ramanathan ,  Rolf-Peter Ryseck ,  Michael G. Neubauer

IPC分类号： G01N33/48

CPC分类号： G01N33/5008 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/28 ,  C07K2319/30 ,  C12Q1/6883 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/5011 ,  G01N33/5091 ,  G01N33/566 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/6893 ,  G01N2333/726 ,  G01N2500/04 ,  G01N2510/00 ,  G01N2800/347 ,  Y10T436/143333

摘要： The present invention provides novel polynucleotides encoding HGPRBMY23 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel HGPRBMY23 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides, particularly renal diseases and/or disorders, colon cancer, breast cancer, and diseases and disorders related to aberrant NFKB modulation. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.

摘要翻译： 本发明提供了编码HGPRBMY23多肽的新型多核苷酸，其片段及其同源物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 本发明还涉及将这些新型HGPRBMY23多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症，特别是肾脏疾病和/或病症，结肠癌，乳腺癌的诊断和治疗方法 以及与异常NFκB调节相关的疾病和病症。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

公开(公告)号：US07211423B2

公开(公告)日：2007-05-01

申请号：US11186999

申请日：2005-07-21

申请人： Dong Cheng ,  John N. Feder ,  Luping Chen ,  Ching-Hsuen Chu

发明人： Dong Cheng ,  John N. Feder ,  Luping Chen ,  Ching-Hsuen Chu

IPC分类号： C12N9/10 ,  C12N15/70 ,  C12N1/20 ,  C12N5/16 ,  C12Q1/68 ,  C12P21/06 ,  C07H21/04

CPC分类号： C12N9/93 ,  C12Y604/01002

摘要： The present invention relates generally to novel nucleotide and amino acid sequences, and more particularly to novel human acetyl CoA carboxylase 2 (ACC2) and rat ACC2 sequences. The sequences provided herein can be expressed in a recombinant format. Methods of isolating the ACC2 sequence are also provided, which can be employed to isolate any ACC sequence. The ACC2 sequences can be employed in therapeutic applications to diagnose or treat a condition associated with ACC2. The invention also relates to the identification of modulators of ACC activity using the recombinant human ACC2 enzyme as the screening target.

摘要翻译： 本发明一般涉及新的核苷酸和氨基酸序列，更具体地涉及新的人乙酰CoA羧化酶2（ACC2）和大鼠ACC2序列。 本文提供的序列可以以重组形式表达。 还提供了分离ACC2序列的方法，其可用于分离任何ACC序列。 ACC2序列可用于治疗应用以诊断或治疗与ACC2相关的病症。 本发明还涉及使用重组人ACC2酶作为筛选靶标鉴定ACC活性的调节剂。

公开(公告)号：US07078513B1

公开(公告)日：2006-07-18

申请号：US09497957

申请日：2000-02-04

申请人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

发明人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/70539 ,  C12Q1/6883

摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂和小分子治疗剂。

公开(公告)号：US06924265B2

公开(公告)日：2005-08-02

申请号：US09901956

申请日：2001-07-09

申请人： John N. Feder ,  Randall C. Schatzman ,  Pamela J. Bjorkman ,  Melanie Bennett ,  Jose Lebron

发明人： John N. Feder ,  Randall C. Schatzman ,  Pamela J. Bjorkman ,  Melanie Bennett ,  Jose Lebron

IPC分类号： A61K38/00 ,  A61K38/10 ,  C07K14/74 ,  C07K7/08

CPC分类号： C07K14/70539 ,  A61K38/00

摘要： The present invention relates to peptides and peptide analogues designed from HFE protein. In particular, it relates to peptides and peptide analogues designed from an alpha-1 region of HFE protein which lowers the binding affinity of transferrin receptor for transferrin. Such compounds mimic HFE protein function, and reduce iron uptake and/or accumulation by a cell.

摘要翻译： 本发明涉及由HFE蛋白设计的肽和肽类似物。 特别地，它涉及由HFE蛋白的α-1区设计的肽和肽类似物，其降低转铁蛋白受体对转铁蛋白的结合亲和力。 这种化合物模拟HFE蛋白功能，并减少细胞吸收铁和/或积累。

公开(公告)号：US06849399B1

公开(公告)日：2005-02-01

申请号：US08920559

申请日：1997-08-27

申请人： John N. Feder ,  Randall C. Schatzman ,  Zenta Tsuchihashi

发明人： John N. Feder ,  Randall C. Schatzman ,  Zenta Tsuchihashi

IPC分类号： A61K38/00 ,  C07K14/47 ,  C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00

摘要： Methods and compositions are provided for the diagnosis and treatment of iron misregulation diseases, including HFE polypeptides, agonists, and antagonists, and transferrin receptor agonists and antagonists.

摘要翻译： 提供了用于诊断和治疗铁错配疾病的方法和组合物，包括HFE多肽，激动剂和拮抗剂以及转铁蛋白受体激动剂和拮抗剂。

公开(公告)号：US6025130A

公开(公告)日：2000-02-15

申请号：US652265

申请日：1996-05-23

申请人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

发明人： Winston J. Thomas ,  Dennis T. Drayna ,  John N. Feder ,  Andreas Gnirke ,  David Ruddy ,  Zenta Tsuchihashi ,  Roger K. Wolff

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/705 ,  C07K14/74 ,  C07K16/28 ,  C12N15/10 ,  C12N15/85 ,  C12P19/34 ,  C12Q1/68 ,  C12N15/00

CPC分类号： C07H21/04 ,  C07K14/47 ,  C07K14/70539 ,  A61K38/00 ,  A61K48/00 ,  C12Q1/6883

摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also relates to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

摘要翻译： 本发明一般涉及导致疾病遗传性血色素沉着症（HH）的基因及其突变。 更具体地，本发明涉及对应于正常和突变HH基因的DNA序列的鉴定，分离和克隆，以及它们的转录物和基因产物的表征。 本发明还涉及用于筛选HH纯合子的方法等，还涉及HH诊断，产前筛查和诊断以及HH疾病的治疗，包括基因治疗剂，基于蛋白质和基于抗体的治疗剂以及小分子治疗剂。