公开(公告)号：US4858600A

公开(公告)日：1989-08-22

申请号：US113305

申请日：1987-10-28

申请人： Joseph Gross ,  David Lowenstein ,  Menachem Tilman ,  Etan Rosenberg

发明人： Joseph Gross ,  David Lowenstein ,  Menachem Tilman ,  Etan Rosenberg

IPC分类号： A61H15/00

CPC分类号： A61H15/0085 ,  A61H2015/0064 ,  A61H2201/0153 ,  A61H2201/105 ,  A61H2201/1604 ,  A61H2205/022

摘要： A massaging appliance for massaging the face or other part of the body, comprises a housing enclosing an electrical motor, and a cream applicator having a chamber for containing a supply of cream to be applied during massaging. The applicator has a cylindrical side wall closed at one end by a first end wall to be placed in contact with the respective part of the body to be massaged, and closed at its opposite end by a second end wall coupled to the motor to be driven thereby. The first end wall is formed with a plurality of openings each occupied by a ball rotatably mounted therein for dispensing cream to the contacted part of the body, and the second end wall is formed with a central threaded opening. A piston is disposed within the applicator and includes a threaded stem receivable in the threaded opening of the second end wall enabling the piston to be adjusted, to contract or enlarge the chamber, by rotating the applicator side wall with respect to its second end wall.

摘要翻译： 用于按摩身体的脸部或其他部分的按摩器具包括封闭电动马达的外壳，以及具有用于在按摩期间施加的奶油供应的腔室的奶油涂抹器。 施用器具有圆柱形侧壁，其一端通过第一端壁封闭，第一端壁与要按摩的身体的相应部分接触，并且在其相对端通过联接到驱动的电动机的第二端壁封闭 从而。 第一端壁形成有多个开口，每个孔由可旋转地安装在其中的球占据，用于将奶油分配到主体的接触部分，并且第二端壁形成有中心螺纹开口。 活塞设置在施加器内，并且包括可接收在第二端壁的螺纹开口中的螺纹杆，通过相对于其第二端壁旋转施加器侧壁，能够调节活塞以收缩或扩大腔室。

公开(公告)号：US4825867A

公开(公告)日：1989-05-02

申请号：US163047

申请日：1988-03-02

申请人： Joseph Gross ,  David Lowenstein ,  Menahem Tilman ,  Etan Rosenberg

发明人： Joseph Gross ,  David Lowenstein ,  Menahem Tilman ,  Etan Rosenberg

IPC分类号： A45D26/00 ,  A61B17/00

CPC分类号： A45D26/0042 ,  A45D26/0023

摘要： A device for removing body hair comprises a manually-grippable housing, and a hair-plucker body rotatably mounted to the housing and having an exposed section formed with a plurality of gaps in its outer surface which open and close during the rotation of the hair-plucker body to receive, pluck and eject body hair growing on a surface over which the hair-plucker body is moved. The hair-plucker body includes a pair of drums mounted in spaced parallel relationship, and a belt enclosing the drums and engaging their outer surfaces so as to be rotated thereby. The belt is formed with a plurality of gaps extending circumferentially of the belt. One of the drums is configured so as to cause the portion of the belt engaging it to open its gaps, and the other drum is configured so as to cause the portion of the belt engaging it to close its gaps.

公开(公告)号：US4771985A

公开(公告)日：1988-09-20

申请号：US101212

申请日：1987-09-25

申请人： Joseph Gross ,  David Lowenstein ,  Menahem Tilman ,  Etan Rosenberg ,  Alexander Morgulis

发明人： Joseph Gross ,  David Lowenstein ,  Menahem Tilman ,  Etan Rosenberg ,  Alexander Morgulis

IPC分类号： F16K31/385 ,  F16K31/56 ,  F16K31/38

CPC分类号： F16K31/566 ,  F16K31/3855

摘要： A faucet includes a shut-off valve between its inlet connection and its spout, and a valve operator extending below the spout so as to be engageable by a user's hand when located below the spout to receive the water discharged therefrom. The valve operator comprises a stem passing through the spout and a latching device which latches the valve in the "on" position by one operation of the valve operator, and in the "off" position by the next operation.

摘要翻译： 水龙头包括在其入口连接件和其出口之间的截止阀，以及在出口下方延伸的阀门操作器，以便当位于喷口下方时可由用户的手接合以接收从其排出的水。 阀操作器包括通过喷口的阀杆和通过阀操作器的一个操作将阀锁定在“接通”位置的锁定装置，并且通过下一操作在“关闭”位置。

公开(公告)号：US06275717B1

公开(公告)日：2001-08-14

申请号：US09102840

申请日：1998-06-23

申请人： Joseph Gross ,  Meir Reingewirtz ,  Moshe George Katz

发明人： Joseph Gross ,  Meir Reingewirtz ,  Moshe George Katz

IPC分类号： A61B500

CPC分类号： C12Q1/006 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/6848

摘要： A method of calibrating an analyte sensor in vivo, by providing a first predetermined stimulus to the sensor when the sensor is applied to a subject to produce a first sensor signal, measuring the first sensor signal, and determining a calibration function based on the first measured sensor signal resulting from the predetermined stimulus. The calibration function, when applied to further signals received from the sensor, can be used to provide a calibrated output.

摘要翻译： 一种在体内校准分析物传感器的方法，当将传感器应用于对象以产生第一传感器信号，测量第一传感器信号，并且基于第一测量值确定校准函数时，通过向传感器提供第一预定刺激， 由预定的刺激产生的传感器信号。 当应用于从传感器接收的更多信号时，校准功能可用于提供校准输出。

公开(公告)号：US6157858A

公开(公告)日：2000-12-05

申请号：US997388

申请日：1997-12-23

申请人： Joseph Gross ,  Zvi Nitzan

发明人： Joseph Gross ,  Zvi Nitzan

IPC分类号： A61N1/04 ,  A61N1/30 ,  A61N1/32

CPC分类号： A61N1/044 ,  A61N1/325 ,  A61N1/0436

摘要： The invention is directed to a device for delivering a pharmaceutically active compound or cosmetic substance to a subject comprises a flexible substrate sheet attached to an electronic controller. The controller is provided with a pair of electrical contacts on the underside thereof and is adhered to the sheet by means of a pair of strips of electrically conductive adhesive. The underside of the sheet is printed in two halves with electrically conductive ink to provide a pair of electrodes separated by an insulating barrier. A protuberance extends from each electrode and is folded onto the top of the sheet such that the contacts of the controller are adhered in electrical connection with the protuberances and thus also with the electrodes. The use of an adhesive to connect a controller in electrical communication with the electrodes enables an extremely simple construction of delivery device to be achieved.

摘要翻译： 本发明涉及用于将药学活性化合物或化妆品物质递送到受试者的装置，包括附接到电子控制器的柔性基片。 控制器在其下侧设置有一对电触点，并且通过一对导电粘合剂粘合到片材上。 片材的下侧用导电油墨印刷成两半，以提供由绝缘屏障隔开的一对电极。 突起从每个电极延伸并且被折叠到片材的顶部上，使得控制器的触点与突起电连接并因此粘附在电极上。 使用粘合剂来连接与电极电连通的控制器能够实现非常简单的输送装置的构造。

公开(公告)号：US5997501A

公开(公告)日：1999-12-07

申请号：US647954

申请日：1996-08-19

申请人： Joseph Gross ,  John Gerard Kelly

发明人： Joseph Gross ,  John Gerard Kelly

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M31/00

CPC分类号： A61M5/14248 ,  A61M5/14593 ,  A61M2005/14252 ,  A61M2005/14268

摘要： An intradermal drug delivery device comprises a housing (301a, 301b) having a drug reservoir (312) therewithin and a gas generation chamber (313) separated from the reservoir (312) by a displaceable membrane (311). A microprocessor-controlled electrolytic cell (316a, 316b, 319) provides gas to expand the gas generation chamber (313) and thereby contract the reservoir (312). A hollow needle (310), communicating at an inner end thereof with the reservoir (312), extends from a lower surface (308) of the housing (301) such that contraction of the reservoir (312) forces drug to escape therefrom via the needle (310). The device permits delivery of drugs of relatively large molecular weights at slow controllable rates. A displaceable protective cover (303) is mounted in means (307) allowing movement of the cover (303) between extended and retracted positions (305, 306). The cover (303) has an adhesive lower surface (309) for attachment to the skin of a subject. In use, a release liner is removed, the device is pressed against the skin and the cover (303) snaps back to the retracted position (306), the needle (310) thereby piercing the skin. After use the housing (301) is pulled away and the cover (303) snaps to the extended position (306) before detaching from the skin, thus concealing the needle (310) before disposal.

摘要翻译： PCT No.PCT / IE94 / 00055 Sec。 371日期：1996年8月19日 102（e）日期1996年8月19日PCT 1994年11月17日PCT PCT。 公开号WO95 / 13838 日期1995年5月26日皮内药物递送装置包括其中具有药物储存器（312）的壳体（301a，301b）和通过可移位膜（311）与储存器（312）分离的气体产生室（313）。 微处理器控制的电解池（316a，316b，319）提供气体以膨胀气体生成室（313），从而使储存器（312）收缩。 在其内端与储存器（312）连通的空心针（310）从壳体（301）的下表面（308）延伸，使得储存器（312）的收缩迫使药物经由 针（310）。 该装置允许以较慢的可控速率递送较大分子量的药物。 可移动的保护盖（303）安装在装置（307）中，允许盖（303）在延伸和缩回位置（305,306）之间移动。 盖（303）具有用于附着到受试者皮肤的粘合剂下表面（309）。 在使用中，移除剥离衬垫，该装置被压靠在皮肤上，并且盖（303）卡扣回到缩回位置（306），针（310）从而刺穿皮肤。 在使用之后，将壳体（301）拉开并且在从皮肤脱离之前盖子（303）卡扣到延伸位置（306），从而在处置之前隐藏针头（310）。

公开(公告)号：US5925030A

公开(公告)日：1999-07-20

申请号：US793497

申请日：1997-09-29

申请人： Joseph Gross ,  John Gerard Kelly

发明人： Joseph Gross ,  John Gerard Kelly

IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M5/142 ,  A61M5/145 ,  A61M31/00 ,  A61M37/00

CPC分类号： A61M5/14593 ,  A61K9/0009 ,  A61M31/002 ,  A61M2005/14204

摘要： Oral drug delivery device having a housing with walls of water permeable material and having at least two chambers separated by a displaceable membrane. The first chamber receives drug and has an orifice through which the drug is expelled under pressure. The second chamber contains at least one of two spaced apart electrodes forming part of an electric circuit which is closed by the ingress of an aqueous ionic solution into the second chamber. When current flows through the circuit, gas is generated and acts on the displaceable membrane to compress the first chamber and expel the active ingredient through the orifice for progressive delivery to the gastrointestinal tract.

摘要翻译： PCT No.PCT / IE95 / 00039 Sec。 371日期：1997年9月29日 102（e）日期1997年9月29日PCT提交1995年8月4日PCT公布。 出版物WO96 / 04953 日期1996年2月22日具有具有水可渗透材料壁的壳体并且具有由可置换膜隔开的至少两个室的口腔输送装置。 第一个房间接受药物并具有一个孔口，药物通过该口在压力下排出。 第二室包含形成电路的一部分的两个间隔开的电极中的至少一个，其通过将离子水溶液进入第二室而闭合。 当电流流过电路时，产生气体并作用在可移动膜上以压缩第一室并通过孔排出活性成分以逐渐递送至胃肠道。

公开(公告)号：US5814020A

公开(公告)日：1998-09-29

申请号：US708230

申请日：1996-09-06

申请人： Joseph Gross

发明人： Joseph Gross

IPC分类号： A61M5/142 ,  A61M5/145 ,  A61M37/00

CPC分类号： A61M5/14248 ,  A61M5/14593 ,  A61M2005/14204 ,  A61M2005/14252 ,  A61M2005/1426 ,  A61M2005/14264

摘要： A medicament delivery device has a reservoir within a housing and means for driving medicament from the reservoir. The device is provided with a filling mechanism upon which a medicament container sealed by a penetrable stopper is mounted. The mechanism comprises an internal bore which accommodates an internal rod from which a needle projects. Needle is hollow and is in communication with the reservoir. In order to fill the reservoir, the container is pressed into the bore, causing the needle to pierce the stopper, the stopper abutting against the rod and acting as a piston to drive medicament from the container as the container is pushed into the bore and moves relative to the stopper. Thus, the reservoir can be filled with the sterile medicament which is stable when stored in the container, and the filling is easily accomplished without the use of a syringe. A further advantageous feature is provided by a delivery needle which is mounted on the periphery of the lower surface of the housing. This configuration allows the driving means to be located adjacent to the skin, thereby, providing a more stable temperature and more predictable operation of the device.

摘要翻译： 药物输送装置具有在壳体内的储存器和用于从贮存器驱动药物的装置。 该装置设置有填充机构，安装由可穿透塞子密封的药物容器。 该机构包括内孔，其容纳有针头从中突出的内部杆。 针是中空的，并且与储存器连通。 为了填充储存器，容器被压入孔中，导致针刺穿止动器，止动件抵靠杆并用作活塞，以在容器被推入孔中时从容器驱动药物并移动 相对于塞子。 因此，储存器可以填充储存在容器中时是稳定的无菌药物，并且在不使用注射器的情况下容易地实现填充。 通过安装在壳体的下表面的周边上的输送针来提供另一有利的特征。 这种构造允许驱动装置位于皮肤附近，从而提供更稳定的温度和更可预测的装置的操作。

公开(公告)号：US5807375A

公开(公告)日：1998-09-15

申请号：US556744

申请日：1995-11-02

申请人： Joseph Gross ,  John Gerard Kelly

发明人： Joseph Gross ,  John Gerard Kelly

IPC分类号： A61M5/00 ,  A61B5/00 ,  A61K9/70 ,  A61M1/36 ,  A61M5/142 ,  A61M5/172 ,  C07C253/34 ,  C12Q1/25 ,  G01N27/327 ,  A61K9/32 ,  A61M31/00 ,  A61B5/05

CPC分类号： A61M5/14248 ,  A61B5/14865 ,  A61B5/6848 ,  A61K9/0021 ,  A61K9/7023 ,  A61M5/14244 ,  A61M5/1723 ,  C07C253/34 ,  A61M2005/14204 ,  A61M2005/14268 ,  A61M2005/1726 ,  A61M2205/8206

摘要： A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject's plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject's skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject's plasma.

公开(公告)号：US5799663A

公开(公告)日：1998-09-01

申请号：US716331

申请日：1996-12-23

申请人： Joseph Gross ,  John Gerard Kelly

发明人： Joseph Gross ,  John Gerard Kelly

IPC分类号： A24F47/00 ,  A61M15/06

CPC分类号： A24F47/002

摘要： A nicotine oral delivery device, which includes a hollow housing (10) and a hollow mouthpiece (14) which may be detachable connected to the housing (10) or may form with the housing a single piece. The mouthpiece includes a nicotine-containing material (16), in the form of a gel, on one or more of the outer surfaces of the mouthpiece. The housing (10) may also include flavoring (20), such as menthol. The nicotine-containing material (16) may be located as a layer on the mouthpiece (14), or in holes in the mouthpiece or under a permeable membrane (18) covering a portion of the mouthpiece (14). Where the mouthpiece and housing are separate pieces, the mouthpiece may be disposable while the housing reusable.

摘要翻译： PCT No.PCT / IE95 / 00019 Sec。 371日期：1996年12月23日 102（e）日期1996年12月23日PCT提交1995年2月17日PCT公布。 公开号WO95 / 24135 日期1995年9月14日一种尼古丁口服递送装置，其包括中空的外壳（10）和中空的吸嘴（14），其可拆卸地连接到外壳（10）或者可以与外壳一体形成。 所述接口管在所述接口管的一个或多个外表面上包括呈凝胶形式的含尼古丁的材料（16）。 壳体（10）还可以包括调味剂（20），例如薄荷醇。 含尼古丁的材料（16）可以位于接口（14）上的层，或位于接口管中的孔中，或位于覆盖接口（14）的一部分的可渗透膜（18）下方。 当接口管和外壳是分开的部件时，接口管可以是一次性的，而外壳可重复使用。