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公开(公告)号:US20070048844A1
公开(公告)日:2007-03-01
申请号:US11550284
申请日:2006-10-17
申请人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
CPC分类号: A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号:US20070048277A1
公开(公告)日:2007-03-01
申请号:US11549760
申请日:2006-10-16
申请人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
CPC分类号: A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号:US20070041936A1
公开(公告)日:2007-02-22
申请号:US11550652
申请日:2006-10-18
申请人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
发明人: Lowell Brady , Kevin Klucher , Chung Chan , Dennis Dong , Hong Liu , Paul Sheppard , Thomas Bukowski
CPC分类号: A61K38/20 , A61K38/00 , C07K14/54 , C07K14/555 , C07K2319/00 , Y10S435/81 , Y10S435/975 , Y10S514/894
摘要: Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
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公开(公告)号:US20060223987A1
公开(公告)日:2006-10-05
申请号:US11450178
申请日:2006-06-09
CPC分类号: C07K14/4723 , A61K38/00 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481
摘要: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the β-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
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公开(公告)号:US20060070635A1
公开(公告)日:2006-04-06
申请号:US11238361
申请日:2005-09-29
CPC分类号: A46D1/0238 , A45D40/26 , A46B1/00 , A46B9/021 , A46B2200/1053 , A46B2200/106 , A46D1/00
摘要: A cosmetic brush and a process of making same. The brush comprises a substantially longitudinal stem and a plurality of bristles, each bristle extending from a base associated with the stem and terminating with a free end, each bristle having external walls and a longitudinal axis, the brush further having a major axis disposed along the stem, wherein the plurality of bristles comprises selected bristles, each of the selected bristles having at least one external depression oriented in a direction substantially parallel to the longitudinal axis of the selected bristle. The process comprises the steps of forming a hollow stem from a first moldable material; providing a plurality of bristle-forming channels surrounding and abutting the hollow stem, each of the bristle-forming channels, the plurality of bristle-forming channels comprising selected bristle-forming channels having at least one protuberance; injecting a second moldable material into the hollow stem under pressure sufficient to rapture the hollow stem in predetermined locations corresponding to the bristle-forming channels and to fill the bristle-forming channels with the second moldable material; and solidifying the second moldable material.
摘要翻译: 化妆刷及其制作方法。 刷子包括基本上纵向的杆和多个刷毛,每个刷毛从与杆相关联的基部延伸并且终止于自由端,每个刷毛具有外壁和纵向轴线,刷子还具有沿着轴线布置的长轴 杆,其中所述多个刷毛包括选定的刷毛,所选择的刷毛中的每一个具有至少一个在基本上平行于所选择的刷毛的纵向轴线的方向上定向的外凹部。 该方法包括从第一可模制材料形成中空杆的步骤; 提供围绕和邻接中空杆的多个刷毛形成通道,每个刷毛形成通道,多个刷毛形成通道包括具有至少一个突起的选定的刷毛形成通道; 在足以在相应于刷毛形成通道的预定位置中破裂中空杆的压力下将第二可模制材料注入中空杆中,并用第二可模制材料填充刷毛形成通道; 并固化第二可模制材料。
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公开(公告)号:US20060024805A1
公开(公告)日:2006-02-02
申请号:US11242243
申请日:2005-10-03
申请人: Paul Sheppard , Nand Baindur , Theresa Deisher , Paul Bishop , David Taft
发明人: Paul Sheppard , Nand Baindur , Theresa Deisher , Paul Bishop , David Taft
CPC分类号: C12N9/6489 , C07K14/47
摘要: The present invention relates to polynucleotide and polypeptide molecules for zdint1, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are believed to be cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint1 polypeptides.
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公开(公告)号:US20050287584A1
公开(公告)日:2005-12-29
申请号:US11201341
申请日:2005-08-10
申请人: Paul Sheppard , Debra Gilbertson
发明人: Paul Sheppard , Debra Gilbertson
IPC分类号: C12N15/09 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/47 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/68
CPC分类号: C07K16/18 , A61K38/00 , C07K14/47 , C07K2319/00 , C07K2319/02
摘要: The present invention relates to polynucleotide and polypeptide molecules a for zsig46 polypeptide, a novel secreted protein located on human chromosome 13. The zsig46 polypeptides, and polynucleotides encoding them, are secreted proteins and may be used in the study of receptors for which a ligand has not yet been identified, of secretory pathways and the like. The present invention also includes antibodies to the zsig46 polypeptides.
摘要翻译: 本发明涉及用于zsig46多肽的多核苷酸和多肽分子a,位于人染色体13上的新型分泌蛋白.Zsig46多肽和编码它们的多核苷酸是分泌蛋白,可用于研究配体具有的受体 尚未鉴定出分泌途径等。 本发明还包括针对zsig46多肽的抗体。
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公开(公告)号:US20050176100A1
公开(公告)日:2005-08-11
申请号:US11007013
申请日:2004-12-08
申请人: Paul Sheppard
发明人: Paul Sheppard
CPC分类号: C12N9/6489 , A61K38/00 , A61K48/00 , C07K2319/00 , C12Y304/15001
摘要: Angiotensin-converting enzyme is a zinc metallopeptidase that plays roles in blood pressure regulation and fertility. The catalytic activities of angiotensin converting enzymes include the production of the potent vasopressor angiotensin H from angiotensin I, and the inactivation of the vasodilatory peptide bradykinin. Zace1 is a new form of human zinc metallopeptidase, which includes one zinc-dependent catalytic domain containing the motif “HEXXH” and one downstream “EX(I/V)X(D/S)” motif.
摘要翻译: 血管紧张素转换酶是在血压调节和生育力中发挥作用的锌金属肽酶。 血管紧张素转换酶的催化活性包括从血管紧张素I产生有效的血管紧张素血管紧张素H,以及血管扩张肽缓激肽的失活。 Zace1是人类锌金属肽酶的新形式,其包括一个含有HEXXH基序和一个下游“EX(I / V)X(D / S)”基序的锌依赖性催化结构域。
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公开(公告)号:US20050124801A1
公开(公告)日:2005-06-09
申请号:US10932376
申请日:2004-09-02
申请人: Paul Sheppard , Laura Jelinek
发明人: Paul Sheppard , Laura Jelinek
CPC分类号: C07K14/47 , A61K38/00 , A61K39/00 , C07K2319/00
摘要: Novel mammalian secretory polypeptides, polynucleotides encoding the polypeptides (called Zsig9), and related compositions and methods including antibodies and anti-idiotypic antibodies. Overexpression of these proteins is indicative of the presence of cancer. Antibodies and anti-sense nucleotides can be used therapeutically to treat the disease. Furthermore, antibodies to Zsig9 and nucleotide primers and probes can be used to diagnose the presence of tumors.
摘要翻译: 新型哺乳动物分泌多肽,编码多肽的多核苷酸(称为Zsig9)以及包括抗体和抗独特型抗体的相关组合物和方法。 这些蛋白质的过度表达表明存在癌症。 抗体和反义核苷酸可用于治疗疾病。 此外,可以使用抗Zsig9和核苷酸引物和探针的抗体来诊断肿瘤的存在。
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公开(公告)号:US20050042719A1
公开(公告)日:2005-02-24
申请号:US10676790
申请日:2003-10-01
IPC分类号: C07H21/04 , C07K14/705 , C07K14/72 , C07K14/78
摘要: The present invention relates to polynucleotide and polypeptide molecules for zacrp5, a novel member of the family of proteins bearing a collagen-like domain and a Clq domain. The polypeptides and polynucleotides encoding them, are involved in trimerization and may be used in the study thereof. The present invention also includes antibodies to the zacrp5 polypeptides.
摘要翻译: 本发明涉及用于zacrp5的多核苷酸和多肽分子,其是具有胶原样结构域和Clq结构域的蛋白家族的新成员。 编码它们的多肽和多核苷酸参与三聚化并且可以用于其研究。 本发明还包括针对zacrp5多肽的抗体。
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